Salivary Total Antioxidant Capacity and Lipid Peroxidation in Patients with Erosive Oral Lichen Planus

Shirzad, Atena; Pouramir, Mahdi; Seyedmajidi, Maryam; Jenabian, Niloofar; Bijani, Ali; Mina, Mani

doi:10.5681/joddd.2014.006

Cited by 17 publications

(11 citation statements)

References 47 publications

(38 reference statements)

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“…Overproduction of reactive oxygen species, which is produced following oxidation-reduction imbalance, causes some changes in the proteins, lipids, and DNA and disturbs cellular function. [ 6 23 24 ]…”

Section: Discussionmentioning

confidence: 99%

“…Since a few numbers of studies investigated the oxidant-antioxidant status in patients with OLP, the sample size was calculated based on these previous studies performed on oral type of this condition [Upadhyay[ 34 ] and Shirzad. [ 6 ] In this case—control study, 30 erosive-atrophic OLP and 30 healthy subjects referring to Zahedan Dental School, Zahedan, Iran, over one year period (2018-2019), who met the inclusion criteria were included by simple random sampling method. All participants signed an informed consent form.…”

Section: Methodsmentioning

confidence: 99%

“…When the balance between the production of free radicals and antioxidant defense system does not exist, a situation arises that is called oxidative stress. [ 6 7 ]…”

Section: Introductionmentioning

confidence: 99%

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Salivary Antioxidants Levels in Patients with Oral Lichen Planus

Shirzaiy

Salehian²,

Dalirsani

2022

Indian Journal of Dermatology

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Background: Oral lichen planus (OLP) is one of the most common diseases of the oral mucosa, which exact pathogenesis remains unknown. Free radicals and reactive oxygen species could play an important role in the pathogenesis of oral lichen planus. Aims and Objectives: This study aimed to compare the salivary levels of uric acid, superoxide dismutase, glutathione peroxidase, and albumin in the patients with oral lichen planus and healthy subjects. Materials and Methods: Thirty patients with oral lichen planus and 30 healthy subjects, who were matched for age and sex, were enrolled in this case-control study. The salivary concentration of uric acid, superoxide dismutase, glutathione peroxidase, and albumin were examined in these individuals using the spectrophotometry and coulometric technique. The data were analyzed through Mann-Whitney test and T test by SPSS software (ver. 19). Results: Salivary uric acid and albumin levels in patients with oral lichen planus and healthy controls were not statistically different (p > 0.05); however, the concentrations of salivary superoxide dismutase in OLP patients (660.4 ± 266.4 U/g protein) and healthy controls (935.73 ± 561.9 U/g protein) were significantly different (p < 0/05). Also, salivary glutathione peroxidase levels in healthy controls (1049.98 ± 964.56 mU/mL) were remarkably higher than OLP patients (244.12 ± 170.78 mU/mL) (p < 0/001). Conclusion: The salivary superoxide dismutase concentration, as an indicator of antioxidant system, in OLP patients was significantly higher than healthy subjects. The glutathione peroxidase levels in these patients were remarkably lower than healthy controls. It is suggestive that these markers could be effective in pathogenesis of OLP.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Salivary Antioxidants Levels in Patients with Oral Lichen Planus

Shirzaiy

Salehian²,

Dalirsani

2022

Indian Journal of Dermatology

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“…Further, several have been conducted on precancerous and malignant lesions of the oral mucosa. In a study on erosive lichen planus, as a premalignant lesion, the total antioxidant capacity (TAC) was significantly lower in patients than in healthy individuals, whereas salivary MDA concentrations were higher in patients than in healthy individuals (14).…”

Section: Introductionmentioning

confidence: 98%

Evaluation of Salivary Lipid Peroxidation in Paan Users

Farhad-Mollashahi

Dalirsani

Nakhaee

et al. 2022

Int J High Risk Behav Addict

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Background: One known risk factor for oral cancer is chewing smokeless tobacco, which is common in southeastern Iran. Smokeless tobacco-related oral complications can be evaluated by assessing parameters of oxidative stress. Objectives: This study evaluated salivary malondialdehyde (MDA) levels in paan users and compared them with nonusers. Patients and Methods: In this study, saliva was collected from 50 paan users and 50 nonusers referred to the Zahedan Dental School in Zahedan, Iran. Salivary MDA was assessed based on standard biochemical methods, and the data were analyzed using a t-test and analysis of variance. Results: In the paan users and the controls, the mean MDA was 2.19 ± 1.05 and 1.24 ± 0.62 (nmol/mL), respectively, and both groups showed significant differences (P < 0.001). The daily consumption and duration were significantly correlated with the MDA concentration, respectively (r = 0.722, P < 0.001), (r = 0.764, P < 0.001). Conclusions: In paan users, salivary MDA concentrations were higher. The concentration of salivary MDA increased with the consumption of paan in more significant quantities and for a more extended time.

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“…Various previous studies have shown that the pathogenesis of OLP is associated with oxidative stress, which is mainly manifested as the imbalance between reactive oxygen species (ROS) and antioxidants ( Upadhyay et al, 2010 ; Husain and Kumar, 2012 ). The key factor is the ROS generation stimulated by inflammatory infiltration composed by T cells and cytokines ( Shirzad et al, 2014 ). ROS further induce cellular and DNA damages, and consequently induce cell apoptosis, while the apoptosis of keratinocytes is a hallmark of OLP ( Sankari et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant therapy for patients with oral lichen planus: A systematic review and meta-analysis

et al. 2022

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Aims: This study aimed to systematically review the efficacy and safety of antioxidants for patients with Oral lichen planus (OLP).Methods: Databases, including PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar, were searched up to 30 April 2022, for randomized controlled trials on the antioxidant therapy of OLP. The following endpoints were analyzed: pain score, clinical score, pain resolution rate, clinical resolution rate, and adverse effects.Results: A total of 19 studies met the inclusion criteria, and 17 studies with 704 patients were included in the meta-analysis. The findings showed that antioxidant therapy could significantly reduce the pain score [standardized mean difference −0.72 (−1.36, −0.07), P = 0.03, I2 = 87%, PI2 < 0.00001] and clinical score [SMD −2.06 (−3.06, −1.06), P < 0.0001, I2 = 94%, PI2 < 0.00001] of patients with OLP and improve the pain resolution rate [risk ratio (RR) 1.15 (1.01, 1.31), P = 0.04, I2 = 45%, PI2 = 0.09] and clinical resolution rate [RR 1.40 (1.10, 1.78), P = 0.006, I2 = 72%, PI2 = 0.002].Conclusion: The study demonstrated that antioxidant therapy was beneficial for patients with OLP, and antioxidants might be used to treat OLP.Systematic Review Registration:https://clinicaltrials.gov/, identifier CRD4202233715.

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Salivary Total Antioxidant Capacity and Lipid Peroxidation in Patients with Erosive Oral Lichen Planus

Cited by 17 publications

References 47 publications

Salivary Antioxidants Levels in Patients with Oral Lichen Planus

Salivary Antioxidants Levels in Patients with Oral Lichen Planus

Evaluation of Salivary Lipid Peroxidation in Paan Users

Antioxidant therapy for patients with oral lichen planus: A systematic review and meta-analysis

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