Salivary Testosterone and Cortisol Levels in Tunisian Elderly Male Patients With Mild Alzheimer’s Disease. Implications of Musical Therapy And/Or Physical Rehabilitation

Cheour, S.; Chéour, Chouaieb; Kilani, Chiraz; Guemri, Aymen; Zineddine, Dawser; Khélifa, Riadh; Supriya, Rashmi; Bragazzi, Nicola Luigi; Chéour, Foued; Baker, Julien S.; Gaied-Chortane, Sabri

doi:10.3389/fphys.2022.839099

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…Considering this perspective, in recent years, non-pharmacological interventions aimed at alleviating chronic stress parameters in AD have been assessed with promising achievements [ 27–29 ]. The approach employed in our study follows this trend.…”

Section: Discussionmentioning

confidence: 99%

Early Benefits with Potential Long-Term Risks of a Comprehensive Intervention on Serum Cortisol Levels and Cognitive Performance in Patients with Alzheimer’s Disease

Balietti,

Galeazzi,

Giacconi

et al. 2023

ADR

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Background: Elevated cortisol levels represent a risk factor for Alzheimer’s disease (AD), prompting treatments to lower hormone concentrations for preventive or therapeutic purposes. Objective: To assess the efficacy of a comprehensive intervention (CI) in modulating serum cortisol levels in patients with AD. Methods: CI consisted in a 2-month protocol involving cognitive stimulation, psychological support, lifestyle guidance, leisure activities, and socialization. AD subjects were randomly assigned to experimental (EG, n = 45) and control (CG, n = 45) groups. A wide range of sociodemographic, cognitive, psychosocial, and functional conditions were evaluated before, at the conclusion, and 24 months after CI. Data about lifestyle and drug prescription were also recorded. Results: Baseline evaluations revealed that higher cortisol levels correlated with worse cognitive status (higher CDR and ADAS-Cog values and lower MMSE scores), increased depressive symptoms, and reduced physical and social engagement. Following CI, EG exhibited reduced cortisol levels, improved overall cognitive status, and enhanced verbal working memory and executive functions compared to CG. However, at the 24-month follow-up, EG displayed a rebound effect, characterized by elevated cortisol levels and cognitive decline compared to CG. Conclusions: These findings strengthen the adverse relationship between excessive cortisol and deficits in cognition/behavior in AD, demonstrate the short-term benefits of CI, and emphasize the potential long-term risks, which may be attributed to the fragile nature of the AD brain. Comprehensive interventions can yield positive results, but careful calibration of type and duration is necessary, considering disease progression and the potential need for re-administration.

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Section: Discussionmentioning

confidence: 99%

Early Benefits with Potential Long-Term Risks of a Comprehensive Intervention on Serum Cortisol Levels and Cognitive Performance in Patients with Alzheimer’s Disease

Balietti,

Galeazzi,

Giacconi

et al. 2023

ADR

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show abstract

“…Furthermore, cortisol plays a significant role in a variety of mental and neurodegenerative disorders, such as depression, chronic stress, PTSD, fatigue syndromes, dementia and AD (Cheour et al, 2022;Rasing et al, 2022;García-González et al, 2023;Patel et al, 2024). These mental disorders are often profoundly associated with abnormally elevated levels of cortisol, which can severely damage physiological and mental health if maintained over a long period (Patel et al, 2024).…”

Section: Neurotransmittersmentioning

confidence: 99%

Treatments and regulatory mechanisms of acoustic stimuli on mood disorders and neurological diseases

Chen,

Sun,

Tao

et al. 2024

Front. Neurosci.

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Acoustic stimuli such as music or ambient noise can significantly affect physiological and psychological health in humans. We here summarize positive effects of music therapy in premature infant distress regulation, performance enhancement, sleep quality control, and treatment of mental disorders. Specifically, music therapy exhibits promising effects on treatment of neurological disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). We also highlight regulatory mechanisms by which auditory intervention affects an organism, encompassing modulation of immune responses, gene expression, neurotransmitter regulation and neural circuitry. As a safe, cost-effective and non-invasive intervention, music therapy offers substantial potential in treating a variety of neurological conditions.

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Testosterone, oxytocin and co-operation: A hypothesis for the origin and function of music

Fukui

Toyoshima²

2023

Front. Psychol.

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Since the time of Darwin, theories have been proposed on the origin and functions of music; however, the subject remains enigmatic. The literature shows that music is closely related to important human behaviours and abilities, namely, cognition, emotion, reward and sociality (co-operation, entrainment, empathy and altruism). Notably, studies have deduced that these behaviours are closely related to testosterone (T) and oxytocin (OXT). The association of music with important human behaviours and neurochemicals is closely related to the understanding of reproductive and social behaviours being unclear. In this paper, we describe the endocrinological functions of human social and musical behaviour and demonstrate its relationship to T and OXT. We then hypothesised that the emergence of music is associated with behavioural adaptations and emerged as humans socialised to ensure survival. Moreover, the proximal factor in the emergence of music is behavioural control (social tolerance) through the regulation of T and OXT, and the ultimate factor is group survival through co-operation. The “survival value” of music has rarely been approached from the perspective of musical behavioural endocrinology. This paper provides a new perspective on the origin and functions of music.

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Salivary Testosterone and Cortisol Levels in Tunisian Elderly Male Patients With Mild Alzheimer’s Disease. Implications of Musical Therapy And/Or Physical Rehabilitation

Cited by 3 publications

References 52 publications

Early Benefits with Potential Long-Term Risks of a Comprehensive Intervention on Serum Cortisol Levels and Cognitive Performance in Patients with Alzheimer’s Disease

Early Benefits with Potential Long-Term Risks of a Comprehensive Intervention on Serum Cortisol Levels and Cognitive Performance in Patients with Alzheimer’s Disease

Treatments and regulatory mechanisms of acoustic stimuli on mood disorders and neurological diseases

Testosterone, oxytocin and co-operation: A hypothesis for the origin and function of music

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