Salivary SIgA and SIgA 1 in coeliac disease, inflammatory bowel disease and controls

Warner, Ross H.; Stevens, F. M.; McCarthy, C. F.

doi:10.1007/bf02939578

Cited by 9 publications

(7 citation statements)

References 29 publications

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“…While this is consistent with the concept of impaired host defense, Warner et al [ 30 ] observed the opposite effect and detected increased secretion of IgA in patients with inflammatory bowel disease. This would correspond to the postulate of Savage et al [ 31 ] that elevated serum IgA levels are associated with inflammation of the mucosal surfaces throughout the gastrointestinal tract, including the oral cavity.…”

Section: Discussionsupporting

confidence: 84%

Potential Salivary Markers for Differential Diagnosis of Crohn’s Disease and Ulcerative Colitis

Nijakowski

Rutkowski

Eder

et al. 2021

Life

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The properties of the saliva of patients with inflammatory bowel disease (IBD) are poorly recognized. Likewise, the diagnostic potential of saliva for differentiating various forms of IBD is largely unexplored. Therefore, we compared the concentrations of several parameters in unstimulated whole mixed saliva collected in a standardized manner from patients with active IBD unresponsive to conventional therapy. The samples were received from 27 patients with Crohn’s disease (CD), 24 patients with ulcerative colitis (UC), and 51 healthy individuals. Compared to the controls, the salivary concentrations of S100A8/calprotectin, myeloperoxidase, and IgA were significantly decreased in both CD and UC patients. In addition, patients with UC had decreased levels of TNF-R1 and decreased catalase activity. Interestingly, the concentrations of myeloperoxidase and TNF-R1 showed a high differentiation potential for CD and UC (AUC = 0.690 and 0.672, respectively). All these findings are discussed in the context of host defense in the oral cavity, patients’ prior treatment regimens, and smoking habits.

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Section: Discussionsupporting

confidence: 84%

Potential Salivary Markers for Differential Diagnosis of Crohn’s Disease and Ulcerative Colitis

Nijakowski

Rutkowski

Eder

et al. 2021

Life

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“… demonstrated significantly higher salivary total protein, albumin, concentrations of IgA and IgG, as well as salivary peroxidase, ceruloplasmin ferroxidase and myeloperoxidase activities, in patients with celiac disease compared with healthy controls . Patients with celiac disease produced lower amounts of salivary amylase, secretory IgA and IgM compared with healthy controls . No differences in the salivary flow rate of patients with Crohn's disease were observed in this study .…”

Section: Salivary Changes In Systemic Diseases With Possible Oral Muccontrasting

confidence: 47%

Salivary changes in oral mucosal diseases

Hassona¹,

Scully²

2015

Periodontology 2000

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Saliva is a unique biological fluid that can be easily collected and analyzed with low cost and low morbidity. Therefore, there is a growing attention for using salivary biomarkers in the diagnosis and monitoring of disease progress and response to treatment. Salivary changes have been described in relation to oral mucosal diseases. This article discusses the causes and consequences of salivary hypofunction and presents a review of the literature related to changes in salivary parameters in various oral mucosal diseases and in systemic diseases with possible oral mucosal involvement.

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“…The level of SIgA in saliva provides much information about the functional status of the entire mucosal immune system [34]. In addition, its concentration in saliva is high (∼ 35-81 μg/ml) but low in serum (∼9-18 μg/ml) in adults [6,34,35,36]. Moreover, previous studies have shown underglycosylated IgA molecules produced by tonsils could be one origin of glomerular IgA in patients with IgAN [33,37,38].…”

Section: Discussionmentioning

confidence: 99%

Proliferation and Cytokine Production of Human Mesangial Cells Stimulated by Secretory IgA Isolated from Patients with IgA Nephropathy

Liang

Zhou

Xing

et al. 2015

Cell Physiol Biochem

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Background/Aims: IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis, and often aggravates by mucosal infection. Secretory IgA (SIgA) is the dominant immunoglobulin in mucosal immunity, and is deposited in the mesangium in IgAN. The biological effects of SIgA on mesangial cells are poorly understood. Methods: Deposition of SIgA in frozen renal sections from IgAN patients was detected and the association between deposition of SIgA and patients characteristics was analyzed. The biological effects of SIgA and polymeric IgA (pIgA) on human renal mesangial cells were compared. We also studied the molecular mechanism of microRNA regulating the inflammatory effects of SIgA on mesangial cells. Results: Fifty-five of 176 patients had SIgA deposition with higher incidence of infection history and hematuria, lower serum cystatin C, β2 microglobulin, blood urea nitrogen and T-grade in the Oxford classification, compared with patients without SIgA deposition. SIgA stimulated mesangial cells at a higher ratio of proliferation and higher production of interleukin (IL)-6, IL-8, monocyte chemotactic protein 1, transforming growth factor-β1 and fibronectin, compared with SIgA from healthy volunteers. The proliferation and cytokines production in mesangial cells stimulated by SIgA were significantly lower than that stimulated by pIgA. miR-16 targeted the 3′-untranslated region of IL-6 and suppressed its translation in mesangial cells induced by SIgA. Conclusions: The biological effects of SIgA on mesangial cells differ from those of pIgA. SIgA stimulates mesangial cell proliferation and production of proinflammatory cytokines. IL-6 production is regulated by miR-16 in mesangial cells.

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Salivary SIgA and SIgA 1 in coeliac disease, inflammatory bowel disease and controls

Cited by 9 publications

References 29 publications

Potential Salivary Markers for Differential Diagnosis of Crohn’s Disease and Ulcerative Colitis

Potential Salivary Markers for Differential Diagnosis of Crohn’s Disease and Ulcerative Colitis

Salivary changes in oral mucosal diseases

Proliferation and Cytokine Production of Human Mesangial Cells Stimulated by Secretory IgA Isolated from Patients with IgA Nephropathy

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