Salivary Semaphorin 4D level in patients with different severities of periodontitis (observational case–control study)

Alwan, ZahraaM; Mohammed, AyserN

doi:10.4103/mjbl.mjbl_320_22

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…Yet, there is no study investigating the concentrations of CX3CL1 and CX3R1 in saliva about periodontitis with different severities as well as different progression rates, nonetheless, similar results were obtained for both biomarkers investigated in (GCF) and the serum was obtained from patients with periodontitis [2,24]. Accordingly, the severity of periodontal disease may thus affect salivary CX3CL1 and its receptors.…”

Section: Discussionmentioning

confidence: 80%

Salivary Fractalkine Differentiating Periodontitis from Periodontally Healthy Subjects

Harbood,

Abbas

2024

International Journal of Dentistry

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Objective. The chemokine “Fractalkine” (CX3CL1) and its corresponding receptor (CX3CR1), chemokine belonging to the CX3C family, have an essential role in developing several systemic inflammatory disorders. Accordingly, the proliferation, adhesion, and migration of inflammatory cells are all affected by it. In light of this, the present study attempts to address the following questions: (1) Is the salivary level of fractalkine and its receptor associated with periodontitis patients with different severities? (2) Is it possible to distinguish periodontitis from periodontally healthy subjects? Methods. This study included 30 individuals who had been considered controls, having healthy periodontium, and 90 patients with varying stages of periodontitis. The patients were equally divided into three groups: those with Stage I, Stage II, and Stage III. After each subject’s saliva was collected, periodontal markers including bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment loss (CAL) were recorded. Enzyme-linked immunosorbent assays (ELISA) were used to detect the protein levels of salivary CX3CL1 and CX3CR1. Results. In comparison to the control group, patients with periodontitis had statistically increased salivary concentrations of CX3CL1 and CX3CR1 (P <0.001). Additionally, all clinical periodontal indicators (BOP, PPD, and CAL) had a strong association with salivary CX3CL1 and CX3CR1 levels. Furthermore, by using the ROC (receiver operating characteristic), both biomarkers showed a good ability to differentiate periodontitis from periodontally healthy subjects, and an excellent ability to distinguish Stage I and Stage III periodontitis from periodontally healthy subjects. The AUC for salivary CX3L1 and its receptors, CX3R, was 0.93 and 0.8, respectively, to distinguish Stage I from patients with good periodontal health. In contrast, the biomarkers’ AUC for separating individuals with Stage III periodontitis from those in healthy periodontal conditions was 1. Conclusion. Fractalkine and its receptor are linked to periodontitis and may distinguish between periodontitis and healthy periodontal tissues, suggesting its role as a possible part of periodontal disease pathogenesis.

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Section: Discussionmentioning

confidence: 80%

Salivary Fractalkine Differentiating Periodontitis from Periodontally Healthy Subjects

Harbood,

Abbas

2024

International Journal of Dentistry

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Molecular Detection of Trichomonas tenax Using Real-Time Gingivitis Patients in Babylon

Al-Mamoori,

Al-Salihi,

Al-Kahfaji

2024

Med J Babylon

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Background: Studies indicate that Trichomonas tenax is a significant factor in the development of gingivitis and periodontitis in the gingival region. This organism is an opportunist that can thrive in the environment created by periodontal disease. Objectives: The aim of this study is to detect T. tenax using real-time quantitative polymerase chain reaction (RT-qPCR) technique in plaque-induced gingivitis (PIG) patients in Babylon. Materials and Methods: This study involved 50 healthy participants (control group) and 50 patients with PIG. Saliva samples were collected from each patient and transported to the Alharithia and Baghdad laboratories of the Advancement Scientific Office Learning Center for molecular testing. Results: T. tenax infection was identified using RT-qPCR and melting curve analysis in 16% of the gingivitis patients (PIG) exposed to plaque. Furthermore, a statistically significant correlation was observed between patient age groups and the presence of PIG disease, as indicated by the t test (27.568, P = 0.000), and between sex, as determined by the t test (8.573, P = 0.000). Conclusion: This study underscores the higher prevalence of T. tenax in patients with PIG disease. Furthermore, it highlights the correlation between these presence of these parasites and the age and sex of PIG disease patients.

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Salivary Semaphorin 4D level in patients with different severities of periodontitis (observational case–control study)

Cited by 2 publications

References 27 publications

Salivary Fractalkine Differentiating Periodontitis from Periodontally Healthy Subjects

Salivary Fractalkine Differentiating Periodontitis from Periodontally Healthy Subjects

Molecular Detection of Trichomonas tenax Using Real-Time Gingivitis Patients in Babylon

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