Salivary S100A8/A9 in Sjögren's syndrome accompanied by lymphoma

Jazzar, Ahoud; Shirlaw, Penelope; Carpenter, Guy; Challacombe, S. J.; Proctor, Gordon

doi:10.1111/jop.12763

Cited by 20 publications

(22 citation statements)

References 24 publications

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“…Many factors, including systemic diseases, can affect salivary production. Sjögren’s syndrome (SS) is a disease that affects salivary glands, manifesting as hyposalivation and abnormal levels of salivary components [ 2 ]. Sjögren’s syndrome can be classified as primary (pSS) or secondary (sSS) forms.…”

Section: Introductionmentioning

confidence: 99%

Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren’s Syndrome

et al. 2021

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Saliva is a complex oral fluid, and plays a major role in oral health. Primary Sjögren’s syndrome (pSS), as an autoimmune disease that typically causes hyposalivation. In the present study, salivary metabolites were studied from stimulated saliva samples (n = 15) of female patients with pSS in a group treated with low-dose doxycycline (LDD), saliva samples (n = 10) of non-treated female patients with pSS, and saliva samples (n = 14) of healthy age-matched females as controls. Saliva samples were analyzed with liquid chromatography mass spectrometry (LC-MS) based on the non-targeted metabolomics method. The saliva metabolite profile differed between pSS patients and the healthy control (HC). In the pSS patients, the LDD treatment normalized saliva levels of several metabolites, including tyrosine glutamine dipeptide, phenylalanine isoleucine dipeptide, valine leucine dipeptide, phenylalanine, pantothenic acid (vitamin B5), urocanic acid, and salivary lipid cholesteryl palmitic acid (CE 16:0), to levels seen in the saliva samples of the HC. In conclusion, the data showed that pSS is associated with an altered saliva metabolite profile compared to the HC and that the LLD treatment normalized levels of several metabolites associated with dysbiosis of oral microbiota in pSS patients. The role of the saliva metabolome in pSS pathology needs to be further studied to clarify if saliva metabolite levels can be used to predict or monitor the progress and treatment of pSS.

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Section: Introductionmentioning

confidence: 99%

Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren’s Syndrome

et al. 2021

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“…Sjogrens syndrome (SS) is an autoimmune disease that affects the exocrine glands of the body, including the salivary glands, and is associated with a significantly higher risk of developing lymphoma [ 130 ]. A recent study revealed that the levels of the pro-inflammatory heterodimer, S100A8/A9, in saliva could discriminate between healthy, SS, and mucosa-associated lymphoid tissue lymphoma (MALT-L), illustrating its potential as a salivary biomarker for the monitoring of SS progression [ 131 ]. Katz et al identified potential biomarkers of MM-associated bone disease in the saliva of MM patients.…”

Section: Salivamentioning

confidence: 99%

Clinical Proteomics of Biofluids in Haematological Malignancies

Dunphy

O’Mahoney

Dowling

et al. 2021

IJMS

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Since the emergence of high-throughput proteomic techniques and advances in clinical technologies, there has been a steady rise in the number of cancer-associated diagnostic, prognostic, and predictive biomarkers being identified and translated into clinical use. The characterisation of biofluids has become a core objective for many proteomic researchers in order to detect disease-associated protein biomarkers in a minimally invasive manner. The proteomes of biofluids, including serum, saliva, cerebrospinal fluid, and urine, are highly dynamic with protein abundance fluctuating depending on the physiological and/or pathophysiological context. Improvements in mass-spectrometric technologies have facilitated the in-depth characterisation of biofluid proteomes which are now considered hosts of a wide array of clinically relevant biomarkers. Promising efforts are being made in the field of biomarker diagnostics for haematologic malignancies. Several serum and urine-based biomarkers such as free light chains, β-microglobulin, and lactate dehydrogenase are quantified as part of the clinical assessment of haematological malignancies. However, novel, minimally invasive proteomic markers are required to aid diagnosis and prognosis and to monitor therapeutic response and minimal residual disease. This review focuses on biofluids as a promising source of proteomic biomarkers in haematologic malignancies and a key component of future diagnostic, prognostic, and disease-monitoring applications.

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“…Screening the non-invasive biomarkers from the saliva and tears has a significant potential too. These fluids represent a crucial source of valuable biomarkers as LACTO or LIPOC-1 tear proteins or S100A8/A9, a molecule found in the saliva of pSS that correlates with a higher risk of developing lymphoma [15,16].…”

Section: Primary Sjogren Syndromementioning

confidence: 99%

Invariant NKT Cells and Rheumatic Disease: Focus on Primary Sjogren Syndrome

Rizzo

Barbera

Pizzo

et al. 2019

IJMS

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Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology. Invariant natural killer (NK) T cells (iNKT) are a T-cell subset able to recognize glycolipid antigens. Their function remains unclear, but studies have pointed out their ability to modulate the immune system through the promotion of specific cytokine milieu. In this review, we discussed the possible role of iNKT in pSS development, as well as their implications as future markers of disease activity.

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Salivary S100A8/A9 in Sjögren's syndrome accompanied by lymphoma

Abstract: The results suggest that salivary levels of S100A8/A9 can aid in differentiating between SS, disease control and healthy control subjects, especially the subgroups of SS with lymphoma or at higher risk of lymphoma.

Cited by 20 publications

References 24 publications

Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren’s Syndrome

Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren’s Syndrome

Clinical Proteomics of Biofluids in Haematological Malignancies

Invariant NKT Cells and Rheumatic Disease: Focus on Primary Sjogren Syndrome

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