Salivary proteins as a biomarker for dental caries—A systematic review

Martins, Carla; Buczynski, Ana Karla; Maia, Lucianne Cople; Siqueira, Walter L.; Castro, Glória Fernanda Barbosa de Araújo

doi:10.1016/j.jdent.2012.10.015

Cited by 51 publications

(45 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is caused by complex interactions among acid-producing bacteria, fermentable carbohydrates and many host factors including saliva. One of the main causative agent of this condition being bacteria [1].…”

Section: Introductionmentioning

confidence: 99%

Salivary proteins as biomarkers in dental caries: In vivo study

Nireeksha¹,

Hegde²,

N³

et al. 2017

Dent Oral Craniofac Res

View full text Add to dashboard Cite

The aim of the study was to determine the relationship between salivary proteins and dental caries. 80 healthy adults were further divided into caries free (N=20) and caries active (N=60) based on DMFT index. Caries active was further divided into group I (D=1-3), group II (D=4-10), group III (D= >10).Saliva samples collected were further analysed for salivary total protein levels, salivary IgA levels, salivary mucin levels, salivary albumin/globulin ratio, salivary C-reactive protein levels and proline rich proteins. The data was then statistically analysed using one way ANOVA test and Post Hoc Tukey's test. P value < 0.05 was considered as statistically significant. Study showed significantly high levels of salivary total protein, salivary IgA and salivary albumin globulin ratio in caries free group. Salivary mucin and salivary C-reactive protein levels were significantly high in caries active group. 95% proline rich protein bands were present in caries free group, whereas caries active group showed 65% proline rich protein bands. This study adds to better understanding of salivary components and their role in dental caries. Modulation of these proteins could play an important role in determining the onset and progression of caries, opening a new avenue of caries prevention.

show abstract

Section: Introductionmentioning

confidence: 99%

Salivary proteins as biomarkers in dental caries: In vivo study

Nireeksha¹,

Hegde²,

N³

et al. 2017

Dent Oral Craniofac Res

View full text Add to dashboard Cite

show abstract

“…They are particularly important for reviewing controversial therapeutic areas (8). These studies help to clarify and synthesise the evidence available in the literature and may help clinicians and researchers in their daily work.…”

Section: Discussionmentioning

confidence: 99%

“…This systematic review was registered in the PROSPERO database, registry number CRD42015029574, and followed the PRISMA Statements (8).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Does Conventional Endodontic Treatment Impact Oral Health-related Quality of Life? A Systematic Review

ANTUNES¹,

SOUZA²,

SALLES³

et al. 2017

Eur Endod J

View full text Add to dashboard Cite

Could conventional endodontic treatment have an impact on oral health-related quality of life? There are still unresolved questions regarding this theme. In order to answer them, a systematic review on the available literature was undertaken to identify the methodological quality of and the risk of bias in all relevant studies. A broad search for articles was conducted, and only articles published before May 2016 were considered for review. The following portals were used: Pubmed, VHL (Medline, SciELO, Lilacs and BBO), Cochrane Library, and Web of Science. The keywords used for the search were 'quality of life' and 'root canal treatment. ' Furthermore, we included MeSH synonyms, related terms and free terms. Articles written in any language were included according to the PICOS approach (population, intervention, comparison, outcome and study design). After application of these eligibility criteria, selected articles were qualified by assessing their methodological quality and potential risk of bias. The initial search identified 302 references. After excluding duplicated abstracts and analysing the titles and abstracts, 6 were selected. One study was added via manual search of the reference lists. From these, 2 were eligible for quality assessment and were classified as being of high methodological quality and as having low risk of bias. Based on these studies, it can be concluded that conventional endodontic treatment improves oral health-related quality of life. However, these results should be interpreted with caution, due to the lack of important methodological details in the included studies. Additional investigations are warranted to provide more evidence on this subject. Keywords: Conventional endodontic treatment, oral health, quality of life, satisfaction, systematic review, therapeutics INTRODUCTIONThere is an increasing interest in the effect that dental treatments have on quality of life. The root canal treatment is an important part of this because endodontic problems are a common occurrence in dental practice and are a key reason patients seek dental care (1). Oral health-related quality of life (OHRQoL) is a multidimensional construct that reflects, among other things, the comfort of the individual when feeding and during sleep, social interactions, self-esteem and satisfaction with their oral health (2). The scientific dental community has made efforts to develop adequate instruments to evaluate the extent to which certain oral conditions occur within affected populations, and the effectiveness of health services in this area. Instruments measuring OHRQoL have become essential for measuring the population's perception of the impact of oral disorders on well-being, as well as for the evaluation of a treatment regimen's impact on the affected population´s quality of life (3). ABSTRACT HIGHLIGHTS• To date, evidence of the effectiveness of endodontic treatment and criteria of success have mainly been considered in terms of clinical outcome.• There is a lack of information of treatment outcomes from p...

show abstract

“…Thus, the relationship between dental caries and human salivary proteins is not well defined, and biomarker information remains unclear. Moreover, no studies have addressed saliva proteome differences in early childhood dental caries [Al-Tarawneh et al, 2011;Martins et al, 2012]. To understand the possible relationship between salivary peptides and dental caries, further investigation of specific proteins is essential.…”

mentioning

confidence: 99%

Magnetic Bead-Based Salivary Peptidome Profiling Analysis for Severe Early Childhood Caries

Ao²,

Wang³

et al. 2014

Caries Res

View full text Add to dashboard Cite

Objective: To investigate the differential salivary protein expression profiles between children with severe early childhood caries (S-ECC) and caries-free (CF) children at the age of 3 years. Methods: We used matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) combined with weak cation exchange magnetic beads, and peptide mass fingerprints were created by scanning mass spectrometry signals. Salivary samples from 20 children were analyzed (10 for each group). Results: Eleven protein peaks were significantly different (p < 0.05) between the two groups. Eight of these peaks were higher in the S-ECC group and three were higher in the CF group. To establish a diagnostic model for discrimination between the two groups, we chose three peptides (3,186.2, 3,195.8 and 3,324.8 Da) that exhibited the best fitted curve, by which the two groups were better separated when compared with other combinations. Conclusions: The salivary biomarkers identified revealed significant differences between the CF and the S-ECC group. Our results provide novel insight into the salivary protein profile of preschool-age children with dental caries and may lead to the development of a new strategy for screening high-risk populations.

show abstract

Salivary proteins as a biomarker for dental caries—A systematic review

Cited by 51 publications

References 17 publications

Salivary proteins as biomarkers in dental caries: In vivo study

Salivary proteins as biomarkers in dental caries: In vivo study

Does Conventional Endodontic Treatment Impact Oral Health-related Quality of Life? A Systematic Review

Magnetic Bead-Based Salivary Peptidome Profiling Analysis for Severe Early Childhood Caries

Contact Info

Product

Resources

About