Salivary prostaglandin concentrations: possible state indicators for major depression

Nishino, Seiji; Ueno, Ryuji; Ohishi, Kazuhiro; Sakai, Tadaaki; Hayaishi, O

doi:10.1176/ajp.146.3.365

Cited by 64 publications

(10 citation statements)

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“…PGE 2 is increased in the CSF, [143] serum, [144] and saliva [145] of patients with MDD and correlates with the severity of depression [146]. Mastocytosis, a disorder in which there is overproduction of PGD 2 , often manifests depressive symptomatology,147 and PGs influence behaviour, [148] sleep, [149] and appetite [150].…”

Section: Pathophysiologic Links Between Asthma and Depressionmentioning

confidence: 99%

Psychological Factors in Asthma

Lieshout

MacQueen

2008

All Asth Clin Immun

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Asthma has long been considered a condition in which psychological factors have a role. As in many illnesses, psychological variables may affect outcome in asthma via their effects on treatment adherence and symptom reporting. Emerging evidence suggests that the relation between asthma and psychological factors may be more complex than that, however. Central cognitive processes may influence not only the interpretation of asthma symptoms but also the manifestation of measurable changes in immune and physiologic markers of asthma. Furthermore, asthma and major depressive disorder share several risk factors and have similar patterns of dysregulation in key biologic systems, including the neuroendocrine stress response, cytokines, and neuropeptides. Despite the evidence that depression is common in people with asthma and exerts a negative impact on outcome, few treatment studies have examined whether improving symptoms of depression do, in fact, result in better control of asthma symptoms or improved quality of life in patients with asthma.

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Section: Pathophysiologic Links Between Asthma and Depressionmentioning

confidence: 99%

Psychological Factors in Asthma

Lieshout

MacQueen

2008

All Asth Clin Immun

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“…Prostaglandin E2 (PGE2) is an important mediator of inflammation [8]. Increased PGE2 in the saliva, serum and cerebrospinal fluid (CSF) of depressed patients has been described previously [9,10,11,12]. The enzyme cyclooxygenase-2 (COX-2) is involved in the function of PGE2 in the inflammatory pathway.…”

Section: Introductionmentioning

confidence: 99%

Immunology of Major Depression

Müller¹

2014

Neuroimmunomodulation

146

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High levels of several proinflammatory components of the immune system, such as interleukin-6, C-reactive protein, tumor necrosis factor (TNF)-α, or neopterin in patients suffering from major depression (MD) point to the involvement of an inflammatory process in the pathophysiology of MD. The direct and indirect effects of cytokines on neurotransmitter storage and release - mediated by microglia cells and astrocytes - are discussed. The tryptophan/kynurenine metabolism is one of the indirect mechanisms because the enzyme indoleamine 2,3-dioxygenase - a key enzyme of this metabolism in the central nervous system - is driven by pro- and anti-inflammatory cytokines and degrades serotonin. Moreover, neuroactive kynurenines such as kynurenic acid and quinolinic acid act on the glutamatergic neurotransmission as N-methyl-D-aspartate antagonists and agonists, respectively. Alterations of the serotonergic, noradrenergic and glutamatergic neurotransmission have been shown with low-level neuroinflammation and may be involved in symptom generation. Epidemiological and clinical studies show a role for inflammation as a risk factor for MD. A large-scale epidemiological study in MD clearly demonstrates that severe infections and autoimmune disorders are lifetime risk factors for MD. The vulnerability-stress-inflammation model matches with this view as stress may increase proinflammatory cytokines and even contribute to a lasting proinflammatory state. Further support comes from the therapeutic benefit of anti-inflammatory medications such as the cyclo-oxygenase-2 inhibitors, TNF-α antagonists and others, and the anti-inflammatory and immunomodulatory intrinsic effects of antidepressants.

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“…Further, COX inhibitors have been observed to reduce inflammatory mediated behavioral deficits, including depressive-like behavior, in rodents [19, 20, 21]. Heightened prostaglandin levels have been reported in depressed patients [22, 23], and COX inhibitors have been found to have an antidepressant effect [24, 25]. Finally, there is evidence that negative long-term biobehavioral consequences of early psychosocial stress are mediated by prostaglandins and can be blocked with anti-inflammatory treatment.…”

Section: Introductionmentioning

confidence: 99%

Naproxen attenuates sensitization of depressive-like behavior and fever during maternal separation

Hennessy

Stafford

Yusko-Osborne

et al. 2015

Physiology & Behavior

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Early life stress can increase susceptibility for later development of depressive illness though a process thought to involve inflammatory mediators. Isolated guinea pig pups exhibit a passive, depressive-like behavioral response and fever that appear mediated by proinflammatory activity, and which sensitize with repeated separations. Treatment with an anti-inflammatory can attenuate the behavioral response during the initial separation and separation the following day. Here we used the cyclooxygenase inhibitor naproxen to examine the role of prostaglandins in mediating the depressive-like behavior and core body temperature of young guinea pigs during an initial separation, separation the next day, and separation 10 days after the first. The passive, depressive-like behavior as well as fever sensitized with repeated separation. Three days of injection with 14 mg/kg of naproxen prior to the initial separation reduced depressive-like behavior during all three separations. A 28 mg/kg dose of naproxen, however, had minimal effect on behavior. Fever during the early separations was moderated by naproxen, but only at the higher dose. These results suggest a role of prostaglandins in the behavioral and febrile response to maternal separation, and particularly in the sensitization of depressive-like behavior following repeated separation.

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Salivary prostaglandin concentrations: possible state indicators for major depression

Cited by 64 publications

References 0 publications

Psychological Factors in Asthma

Psychological Factors in Asthma

Immunology of Major Depression

Naproxen attenuates sensitization of depressive-like behavior and fever during maternal separation

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