Salivary profile and oxidative stress in children and adolescents with cystic fibrosis

Livnat, Galit; Bentur, Lea; Kuzmisnsky, E.; Nagler, Rafael M.

doi:10.1111/j.1600-0714.2009.00813.x

Cited by 31 publications

(58 citation statements)

References 40 publications

(54 reference statements)

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“…They protect the mucosa against irritative factors, initiate the formation of the dental pellicle that protects the enamel, facilitate the process of mastication and swallowing, and following carbonates and phosphates, constitute the third buffering system that controls the pH. There is a significant increase in protein concentration among patients suffering from CF which has been observed by Aps et al, Modesto et al and Livnat et al 21,36,37 Peker et al, in turn, have not confirmed such a connection. Sialic acid, which is a component of glycoproteins, performs a protective role for the tissues of the oral cavity.…”

Section: Salivamentioning

confidence: 62%

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Oral cavity health among cystic fibrosis patients: Literature overview

Herman¹,

Kowalczyk−Zając²,

Pytrus³

2017

Adv Clin Exp Med

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Cystic fibrosis is a genetic disorder in which the mutation of the Cystis Fibrosis Transmembrane Conductance Regulator (CFTR) gene that codes the protein forming a chloride channel of epithelial cells results in its distorted functioning. The manifestations of the disorder are mainly observed in the respiratory and digestive system. Accumulation of sticky and thick mucus is the dominant clinical symptom; it leads to chronic infections and gradual tissue destruction. Although cystic fibrosis remains incurable, it is currently feasible to extend patients' life expectancy thanks to modern therapy possibilities. As cystic fibrosis is no longer the domain of pediatricians, health care to CF patients needs to be provided by doctors of various specializations. The multidisciplinary team of doctors should include a dentist aware of specific prevention and treatment needs of this group of patients. It results from the fact that in the course of cystic fibrosis it is possible to observe a variety of changes in the oral cavity environment. The study presents dental issues observed in CF patients and reported in literature. Particular attention was paid to dental caries, mineralization disorders of hard dental tissues, gingivitis and the change in the content and properties of saliva; moreover, prevention and treatment options regarding oral cavity health is this group of patients were taken into consideration.

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Section: Salivamentioning

confidence: 62%

“…[36][37][38] The former enzyme initiates the digestion of starch, and it is also capable of bonding with bacteria and the pellicle. As a result, it may have an impact on the carious process.…”

Section: Salivamentioning

confidence: 99%

Oral cavity health among cystic fibrosis patients: Literature overview

Herman¹,

Kowalczyk−Zając²,

Pytrus³

2017

Adv Clin Exp Med

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“…24 In addition, whole saliva samples in younger CF patients have been found to have higher levels of proteins, antioxidants and uric acid compared to controls. 25 All these salivary changes are thought to be related to the chronic oxidative and inflammatory process activity in the oral cavity of these patients and represent biomarkers that could give more clues about the aetiology and monitoring of CF.…”

Section: Cystic Fibrosismentioning

confidence: 99%

Saliva as a diagnostic tool for oral and systemic diseases

Javaid

Ahmed

Durand

et al. 2016

Journal of Oral Biology and Craniofacial Research

300

231

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“…[77][78][79] Endocrinology. In endocrinology, saliva has proven to be a useful diagnostic tool in measuring the concentration of unconjugated steroid hormones and melatonin, even substituting other biological fluids used until now (such as plasma, serum, and urine).…”

Section: 65mentioning

confidence: 99%

Saliva diagnostics – Current views and directions

Kaczor‐Urbanowicz

Carreras‐Presas

Aro

et al. 2016

Exp Biol Med (Maywood)

349

271

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The purpose of this mini-review is to make an update about the present and future applications of saliva as a diagnostic biofluid in many fields of science such as dentistry, medicine and pharmacotherapy. Using saliva as a fluid for diagnostic purposes would be a huge breakthrough for both patients and healthcare providers since saliva collection is easy, non-invasive and inexpensive. We will go through the current main diagnostic applications of saliva, and provide a highlight on the emerging, newly developing technologies and tools for cancer screening, detection and monitoring. AbstractIn this review, we provide an update on the current and future applications of saliva for diagnostic purposes. There are many advantages of using saliva as a biofluid. Its collection is fast, easy, inexpensive, and non-invasive. In addition, saliva, as a ''mirror of the body,'' can reflect the physiological and pathological state of the body. Therefore, it serves as a diagnostic and monitoring tool in many fields of science such as medicine, dentistry, and pharmacotherapy. Introduced in 2008, the term ''Salivaomics'' aimed to highlight the rapid development of knowledge about various ''omics'' constituents of saliva, including: proteome, transcriptome, micro-RNA, metabolome, and microbiome. In the last few years, researchers have developed new technologies and validated a wide range of salivary biomarkers that will soon make the use of saliva a clinical reality. However, a great need still exists for convenient and accurate point-of-care devices that can serve as a non-invasive diagnostic tool. In addition, there is an urgent need to decipher the scientific rationale and mechanisms that convey systemic diseases to saliva. Another promising technology called liquid biopsy enables detection of circulating tumor cells (CTCs) and fragments of tumor DNA in saliva, thus enabling non-invasive early detection of various cancers. The newly developed technology-electric field-induced release and measurement (EFIRM) provides near perfect detection of actionable mutations in lung cancer patients. These recent advances widened the salivary diagnostic approach from the oral cavity to the whole physiological system, and thus point towards a promising future of salivary diagnostics for personalized individual medicine applications including clinical decisions and post-treatment outcome predictions.

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Salivary profile and oxidative stress in children and adolescents with cystic fibrosis

Abstract: Cystic fibrosis patients demonstrated altered salivary profile, especially in antioxidant enzymatic and molecular activity, possibly resulting from the oral cavity's ongoing inflammatory and oxidative process. Free radical mechanisms may be involved in CF pathogenesis.

Cited by 31 publications

References 40 publications

Oral cavity health among cystic fibrosis patients: Literature overview

Oral cavity health among cystic fibrosis patients: Literature overview

Saliva as a diagnostic tool for oral and systemic diseases

Saliva diagnostics – Current views and directions

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