Salivary oestradiol and progesterone levels in premenopausal women with breast cancer

Wang, D.Y.; Fantl, Vera; Habibollahi, F.; Clark, Graham; Fentiman, IS; Hayward, John; Bulbrook, R. D.

doi:10.1016/0277-5379(86)90108-2

Cited by 13 publications

(4 citation statements)

References 20 publications

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“…These concentrations are similar to the serum concentrations of free estradiol, which can diffuse into saliva. A significant correlation (r = 0.78) between salivary estradiol levels and serum levels of free estradiol was reported (Wang et al ., 1986). Salivary estradiol levels followed the same trends as serum estradiol levels during a menstrual cycle (Evans et al ., 1980).…”

Section: (4) the Monitoring Of Hormone Levelsmentioning

confidence: 85%

The Diagnostic Applications of Saliva— A Review

Kaufman

Lamster

2002

Critical Reviews in Oral Biology & Medicine

794

618

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This review examines the diagnostic application of saliva for systemic diseases. As a diagnostic fluid, saliva offers distinctive advantages over serum because it can be collected non-invasively by individuals with modest training. Furthermore, saliva may provide a cost-effective approach for the screening of large populations. Gland-specific saliva can be used for diagnosis of pathology specific to one of the major salivary glands. Whole saliva, however, is most frequently used for diagnosis of systemic diseases, since it is readily collected and contains serum constituents. These constituents are derived from the local vasculature of the salivary glands and also reach the oral cavity via the flow of gingival fluid. Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use.

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Section: (4) the Monitoring Of Hormone Levelsmentioning

confidence: 85%

The Diagnostic Applications of Saliva— A Review

Kaufman

Lamster

2002

Critical Reviews in Oral Biology & Medicine

794

618

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“…In a study total or non-protein bound E2 levels measured in blood samples from normal women were both linearly correlated with the concentration of E2 in matched saliva samples. The amount of free oestradiol in blood was about twice that found in saliva 32 . The increase in saliva Oestriol (Sal-E3) with gestational age was consistent with the well established pattern for serum Oestriol (E3), with the median value exhibiting a small but significant rise between 32 and 33 weeks and a larger rise between 36 and 37 weeks.…”

Section: Introductionmentioning

confidence: 69%

Diagnostic usefulness of salivary reproductive hormones: An update

Rajeswari¹,

Mathan²,

Swaminathan³

2014

Int J of Biomed & Adv Res

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“…However, aptameric detection of estradiol in physiologically relevant fluids for clinical screening and diagnostics has yet to be studied, and can be used to assess ovarian function and risks of breast cancer . Detection of salivary estradiol is advantageous as salivary steroid hormones are found in their free/active form, and there is a good correlation between salivary and serum levels of hormones such as cortisol and estradiol. , For estradiol detection performed under ideal conditions, we obtained an LOD of 0.1 nM (Figure S8, Supporting Information). As saliva contains a higher protein concentration compared to urine, a simple protein precipitation step using methanol was conducted for spiked synthetic saliva samples, to remove protein interferences.…”

Section: Resultsmentioning

confidence: 99%

Colorimetric Detection of Small Molecules in Complex Matrixes via Target-Mediated Growth of Aptamer-Functionalized Gold Nanoparticles

et al. 2015

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A versatile and sensitive colorimetric assay that allows the rapid detection of small-molecule targets using the naked eye is demonstrated. The working principle of the assay integrates aptamer-target recognition and the aptamer-controlled growth of gold nanoparticles (Au NPs). Aptamer-target interactions modulate the amount of aptamer strands adsorbed on the surface of aptamer-functionalized Au NPs via desorption of the aptamer strands when target molecules bind with the aptamer. Depending on the resulting aptamer coverage, Au NPs grow into morphologically varied nanostructures, which give rise to different colored solutions. Au NPs with low aptamer coverage grow into spherical NPs, which produce red-colored solutions, whereas Au NPs with high aptamer coverage grow into branched NPs, which produce blue-colored solutions. We achieved visible colorimetric response and nanomolar detection limits for the detection of ochratoxin A (1 nM) in red wine samples, as well as cocaine (1 nM) and 17β-estradiol (0.2 nM) in spiked synthetic urine and saliva, respectively. The detection limits were well within clinically and physiologically relevant ranges, and below the maximum food safety limits. The assay is highly sensitive, specific, and able to detect an array of analytes rapidly without requiring sophisticated equipment, making it relevant for many applications, such as high-throughput drug and clinical screening, food sampling, and diagnostics. Furthermore, the assay is easily adapted as a chip-based platform for rapid and portable target detection.

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Salivary oestradiol and progesterone levels in premenopausal women with breast cancer

Cited by 13 publications

References 20 publications

The Diagnostic Applications of Saliva— A Review

The Diagnostic Applications of Saliva— A Review

Diagnostic usefulness of salivary reproductive hormones: An update

Colorimetric Detection of Small Molecules in Complex Matrixes via Target-Mediated Growth of Aptamer-Functionalized Gold Nanoparticles

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