Salivary Microbiota Associated with Peripheral Microvascular Endothelial Dysfunction

Kato-Kogoe, Nahoko; Kamiya, Kohei; Sakaguchi, Shoichi; Omori, Michi; Komori, Eri; Kudo, Asako; Nakamura, Shota; Nakano, Takashi; Ueno, Takaaki; Tamaki, Junko; Hoshiga, Masaoki

doi:10.5551/jat.63681

Cited by 2 publications

(2 citation statements)

References 48 publications

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“…This indicates there is no apparent geographical distribution [ 25 ]. Although individual differences are considered normal [ 26 ], salivary microbiota dysbiosis can be used in identifying different diseases, including endothelial dysfunction [ 27 ], hypertension, or pulmonary disorders, such as sleep apnea [ 28 ].…”

Section: Links Between Dysbiotic Oral Microbiota and Valvular Heart D...mentioning

confidence: 99%

The Oral Microbiota in Valvular Heart Disease: Current Knowledge and Future Directions

Neculae

Gosav

Valasciuc

et al. 2023

Life

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Oral microbiota formation begins from birth, and everything from genetic components to the environment, alongside the host’s behavior (such as diet, smoking, oral hygiene, and even physical activity), contributes to oral microbiota structure. Even though recent studies have focused on the gut microbiota’s role in systemic diseases, the oral microbiome represents the second largest community of microorganisms, making it a new promising therapeutic target. Periodontitis and dental caries are considered the two main consequences of oral bacterial imbalance. Studies have shown that oral dysbiosis effects are not limited locally. Due to technological advancement, research identified oral bacterial species in heart valves. This evidence links oral dysbiosis with the development of valvular heart disease (VHD). This review focuses on describing the mechanism behind prolonged local inflammation and dysbiosis, that can induce bacteriemia by direct or immune-mediated mechanisms and finally VHD. Additionally, we highlight emerging therapies based on controlling oral dysbiosis, periodontal disease, and inflammation with immunological and systemic effects, that exert beneficial effects in VHD management.

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Section: Links Between Dysbiotic Oral Microbiota and Valvular Heart D...mentioning

confidence: 99%

The Oral Microbiota in Valvular Heart Disease: Current Knowledge and Future Directions

Neculae

Gosav

Valasciuc

et al. 2023

Life

View full text Add to dashboard Cite

show abstract

“…Внутрисосудистые инфекции изучаются в качестве фактора риска атеросклероза и его осложнений, связанных с тромбозами и эмболиями. Считается, что основу этих процессов составляет бактериальная инвазия эндотелия сосудов, приводящая к нарушению функций эндотелия и свертывания крови и, соответственно, к прогрессирующему атерогенезу [ 1 ] .…”

Section: Introductionunclassified

Filifactor alocis and its associations with anaerobic bacteria in patients with periodontitis and cardiovascular diseases

Николаева,

Янушевич,

Царева

et al. 2023

Clinical Dentistry (Russia)

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Микробное поражение тканей пародонта тесно связано с рядом системных заболеваний; возможно, оно играет важную роль в возникновении коморбидной патологии. Цель работы — идентификация патогена Filifactor alocis в качестве нового диагностического индикатора заболеваний пародонта у больных с хроническим пародонтитом (ХП) и ишемической болезнью сердца (ИБС). Обследовано 180 пациентов с ХП и сердечно-сосудистыми заболеваниями (ССЗ), в том числе острым инфарктом миокарда (ОИМ), стенокардией напряжения I—II функциональных классов, ИБС с постинфарктным кардиосклерозом и показаниями к реваскуляризации миокарда. Контрольную группу составили 60 больных с ХП средней степени тяжести без ССЗ. Проведена оценка стоматологического и кардиологического статуса, эндотелиальной дисфункции, состава ДНК основных видов пародонтопатогенных бактерий, включая новый маркер пародонтита F. alocis, в субгингивальной биопленке пациентов, биохимический анализ крови. Установлена статистически достоверная взаимосвязь между колонизацией субгингивальной биопленки пародонтопатогенными бактериями F. alocis и P. gingivalis с наличием ССЗ. У больных с ИБС частота выявления F. alocis и P. gingivalis, в том числе совместного, выше, чем у людей без ССЗ. Отношение рисков наличия F. alocis и P. gingivalis у больных с ОИМ — 2,76 (95% ДИ 1,24—6,15; p<0,05); у больных с ИБС — 2,25 (95% ДИ 1,00—5,03; p<0,05); со стенокардией — 1,95 (95% ДИ 0,86—4,38; p>0,05). Выявлены взаимосвязи F. alocis и P. gingivalis с клиническими проявлениями острых и хронических ССЗ, что может указывать на их роль в качестве ключевых патогенов воспалительных заболеваний тканей пародонта и вспомогательных патогенов при ССЗ. Результаты проведенного проспективного исследования подтверждают важную роль ключевых пародонтопатогенных видов в рассматриваемой патологии и свидетельствуют о практической необходимости идентификации F. alocis и P. gingivalis у больных ХП, в том числе с коморбидными ССЗ. Microbial damage to periodontal tissues is closely associated with a number of systemic diseases and, possibly, plays an important role in the occurrence of comorbid pathology. The aim of the work is to identify the pathogen Filifactor alocis as a new diagnostic indicator of periodontal disease in patients with chronic periodontitis with coronary heart disease (CHD). . We examined 180 patients with chronic periodontitis (CP) and cardiovascular diseases (CVD), including: acute myocardial infarction (AMI), angina pectoris I—II FC classes (AP), coronary artery disease with postinfarction cardiosclerosis (CAD) and indications for myocardial revascularization. Control group — 60 patients with chronic periodontitis of moderate severity without CVD. Dental and cardiological status, endothelial dysfunction, DNA composition of the main types of periodontal pathogens, including a new marker of periodontitis F. alocis in the subgingival biofilm of patients, and a biochemical blood test were assessed. . Statistically significant relationship found between the colonization of the subgingival biofilm by periodontal pathogens F. alocis and P. gingivalis with the presence of CVD. In patients with coronary artery disease, the frequency of detection of F. alocis and P. gingivalis, including the joint, is higher than in people without CVD. The risk ratio for the presence of F. alocis and P. gingivalis in patients with AMI was 2.76 (95% CI 1.24—6.15; p<0.05); CAD patients — 2.25 (95% CI 1.00—5.03; p<0.05); angina pectoris — 1.95 (95% CI 0.86—4.38; p>0.05). Relationships of F. alocis and P. gingivalis with clinical manifestations of acute and chronic cardiovascular diseases were revealed, which may indicate their role as key pathogens of inflammatory periodontal diseases and auxiliary pathogens in CVD. . The results of a prospective study confirm the important role of key periodontal pathogenic species in the pathology under consideration and indicate the practical need to identify F. alocis and P. gingivalis in patients with CP, including those with comorbid CVD.

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Salivary Microbiota Associated with Peripheral Microvascular Endothelial Dysfunction

Cited by 2 publications

References 48 publications

The Oral Microbiota in Valvular Heart Disease: Current Knowledge and Future Directions

The Oral Microbiota in Valvular Heart Disease: Current Knowledge and Future Directions

Filifactor alocis and its associations with anaerobic bacteria in patients with periodontitis and cardiovascular diseases

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