Salivary Microbiological and Gingival Health Status Evaluation of Adolescents With Overweight and Obesity: A Cluster Analysis

Araujo, Darlle Santos; Klein, Marlise I.; Scudine, Kelly Guedes de Oliveira; Leite, Luana de Sales; Parisotto, Thaís Manzano; Ferreira, Caroline M.; Fonseca, Fernando Luiz Affonso; Perez, Matheus Moreira; Castelo, Paula Midori

doi:10.3389/fped.2020.00429

Cited by 16 publications

(25 citation statements)

References 66 publications

(83 reference statements)

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“…In agreement with published research, we observed that oral bacterial community composition was distinct between lean and obese individuals [24][25][26][27]. In our work, we also observed that the difference in salivary bacterial composition between obese and lean individuals extends to phylogenetic diversity measurements.…”

Section: Obesity Influences Microbial Community Composition Especially In Salivasupporting

confidence: 93%

“…In addition, the abundance of several bacterial taxa including Lactobacillus, Pervotella, Alistipes, Akkermansia, and others vary with obesity status [7,9]. Salivary microbiota of lean and obese individuals also differ in diversity and composition [9,[24][25][26][27]. Abundance of several salivary bacterial taxa including Campylobacter, Aggregatibacter, and Veillonella was reported to be positively associated with obesity [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

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Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa

Bombin

Mosley

Yan

et al. 2021

Preprint

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Obesity is an increasing global health concern and is associated with a broad range of morbidities. The gut microbiota are increasingly recognized as important contributors to obesity and cardiometabolic health. This study aimed to characterize oral and gut microbial communities, and evaluate host:microbiota interactions between clinical obesity classifications. We performed 16S rDNA sequencing on fecal and salivary samples, global metabolomics profiling on plasma and stool samples, and dietary profiling in 135 healthy individuals. We grouped individuals by obesity status, based on body mass index (BMI), including lean (BMI 18-24.9), overweight (BMI 25-29.9), or obese (BMI ≥30). We analyzed differences in microbiome composition, community inter-relationships, and predicted microbial function by obesity status. We found that salivary bacterial communities of lean and obese individuals were compositionally and phylogenetically distinct. An increase in obesity status was positively associated with strong correlations between bacterial taxa, particularly with bacterial groups implicated in metabolic disorders including Fretibacterium, and Tannerella. Consumption of sweeteners, especially xylitol, significantly influenced compositional and phylogenetic diversities of salivary and fecal bacterial communities. In addition, obesity groups exhibited differences in predicted bacterial metabolic activity, which was correlated with host's metabolite concentrations. Overall, obesity was associated with distinct changes in bacterial community dynamics, particularly in saliva. Consideration of microbiome community structure, and inclusion of salivary samples may improve our ability to understand pathways linking microbiota to obesity and cardiometabolic disease.

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Section: Obesity Influences Microbial Community Composition Especially In Salivasupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa

Bombin

Mosley

Yan

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Similar results were found also by Araujo et al, in his research, adolescents with overweight or obesity showed the highest percentages of MS and Bifidobacteria than normal-weight ones. His results are indicating a possible interaction between oral bacteria communities and weight gain [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Observational Study Regarding the Relationship between Nutritional Status, Dental Caries, Mutans Streptococci, and Lactobacillus Bacterial Colonies

Bud

Bică

Stoica

et al. 2021

IJERPH

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The prevalence of dental caries and obesity is high as both raise significant health problems. The objective of this study was to evaluate the relationship between dental caries, the number of salivary colonies forming units of Mutans Streptococci (MS) and Lactobacillus (LB), and the nutritional status in a group of children from Transylvania. This observational study used a sample of 154 school children, aged 9 to 12 years. The prevalence of caries was measured using the decayed, missing, and filled teeth index for deciduous teeth (dmft index) and for permanent teeth (DMFT index). Height and weight were assessed for each subject, and their body mass index (BMI) percentile was calculated. Salivary levels of Mutans Streptococci (MS) and Lactobacillus (LB) were determined using the CRT Bacteria Test from Ivoclar Vivadent. In our study, we found a positive association between the BMI percentile, MS count, LB count, tooth brushing frequency, and the incidence of dental caries in children aged 9 to 12 years old. Future preventive programs should include nutrition control in order to prevent both the apparition of dental caries and obesity in children.

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“…The salivary microbiota's differential diversity and the occurrence of certain bacterial species have been correlated to common oral diseases such as dental caries and periodontitis and systemic diseases, including diabetes, obesity, and cancer [9]. Of the limited available studies related to obesity, few have demonstrated the association of dysbiotic salivary microbiome with obesity in adults [10,11] and adolescents [12][13][14]. For example, the presence of Veillonella, Haemophilus, and Prevotella was correlated with BMI in a Brazilian adolescent population [13].…”

Section: Introductionmentioning

confidence: 99%

Salivary Microbiome Diversity in Kuwaiti Adolescents with Varied Body Mass Index—A Pilot Study

et al. 2021

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The potential role of the salivary microbiome in human diseases has increasingly been explored. The salivary microbiome has been characterized in several global populations, except the Arabian Gulf region. Hence, in this pilot study, we profiled the salivary microbiome of Kuwaiti adolescents with varied body mass indexes (BMI). The analyses of core microbiome composition showed Firmicutes, Bacteroidota, Proteobacteria, Patescibacteria, Fusobacteriota, Actinobacteriota, and Campylobacterota as the common phylum found in the Kuwaiti adolescent population. We also illustrated a diverse microbial community among the sampled individuals grouped according to their BMI. Notably, the overweight group was found with a higher number of distinct taxa than other groups. As such, the core microbiome composition was found to be significantly different (p-value < 0.001) across different BMI groups. Overall, this pilot investigation outlined the microbial diversity and suggested that changes in salivary microbiome composition in people with obese or overweight BMI might reflect their susceptibility to oral diseases.

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Salivary Microbiological and Gingival Health Status Evaluation of Adolescents With Overweight and Obesity: A Cluster Analysis

Cited by 16 publications

References 66 publications

Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa

Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa

Observational Study Regarding the Relationship between Nutritional Status, Dental Caries, Mutans Streptococci, and Lactobacillus Bacterial Colonies

Salivary Microbiome Diversity in Kuwaiti Adolescents with Varied Body Mass Index—A Pilot Study

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