Salivary melatonin levels and sleep-wake rhythms in pregnant women with hypertensive and glucose metabolic disorders: A prospective analysis

Shimada, Mieko; Samejima, Masahiro; Hayase, Mako; Shirai, Fumie

doi:10.5582/bst.2015.01123

Cited by 50 publications

(59 citation statements)

References 42 publications

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“…The MLT receptor has seven transmembrane segments, and is a member of the G protein-coupled receptor superfamily (6). The physiological function of MLT is to communicate information about circadian rhythms to the body in response to outside light (7). In addition, it may play an important role in immunomodulation, antioxidation, neuroprotection, and tumor inhibition (7).…”

Section: Discussionmentioning

confidence: 99%

“…The physiological function of MLT is to communicate information about circadian rhythms to the body in response to outside light (7). In addition, it may play an important role in immunomodulation, antioxidation, neuroprotection, and tumor inhibition (7). Furthermore, MLT may have a role in ophthalmological diseases such as diabetic retinopathy, age-related macular degeneration, glaucoma, cataract and myopia (8).…”

Section: Discussionmentioning

confidence: 99%

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Regulatory mechanism of melatonin on the retinal ganglion cell photoreaction in mice

Hong

Zhou

et al. 2017

Experimental and Therapeutic Medicine

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The study aimed to analyze the regulatory mechanism of melatonin (MLT) on the retinal ganglion cell photoreaction in mice. Forty-eight, 3-week-old healthy ICR mice, regardless of gender, were randomly divided into 4 groups. Group A was exposed to an illumination/dark time of 0 h/24 h, 6 h/18 h in group B, 12 h/12 h in group C and 18 h/6 h in group D, for up to 6 weeks. Four mice in each group were sacrificed at week 1, 3 and 6, respectively, for harvesting of retinal ganglion cells. ELISA was used to detect nocturnal plasma MLT levels at midnight. Immunohistochemistry was used to detect the expression of the retinal MLT receptor and the expression levels of inducible nitric oxide synthase (iNOS) and c-fos protein. The plasma MLT levels, MLT receptor levels and c-fos protein expression levels of group C, after 1, 3 and 6 weeks of light application, were the highest, followed by groups B and D, while group A had the lowest levels. For each illumination time, the iNOS levels of group C were the lowest and group A was the highest. Differences were all statistically significant (P<0.05). In conclusion, appropriate illumination regimens can increase c-fos protein, decrease iNOS activity and regulate the physiological activities of the retinal ganglion cells by regulating the expressions of MLT and its receptor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Regulatory mechanism of melatonin on the retinal ganglion cell photoreaction in mice

Hong

Zhou

et al. 2017

Experimental and Therapeutic Medicine

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“…Recent recognition that clock genes are expressed in the placenta, together with observations linking circadian disruption with compromised placental function, suggests that circadian variation may be an important component of the normal placental phenotype [56]. Of note is that, for both pregnant women with complications in either the second or third trimester and healthy pregnant women, melatonin levels were the highest at night, decreased throughout the early morning, and were the lowest during the day, demonstrating significant daily fluctuations [57].…”

Section: Circadian Rhythms and Cardiovascular Diseasementioning

confidence: 99%

“…Shimada showed that pregnant women with hypertension or diabetes had lower levels of salivary melatonin during the day than healthy pregnant women [57]. Moreover, Reiter suggested that due to the potent antioxidant actions of melatonin, coupled with its virtual absence of toxicity, this indoleamine may have utility in the treatment of pre-eclampsia, intrauterine growth restriction, placental and fetal ischemia/reperfusion [68].…”

Section: Is a Dysfunction Of The Placental Clock Related To Preeclampmentioning

confidence: 99%

The Biological Clock and Vascular Disease: Application to Pregnancy

Karoutsos¹,

Karoutsos²,

Karoutsou³

2017

J Clin Epigenet

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In mammals, the components of the biological clock function peripherally in a complex network and modulate the transcription of specific target genes and their products, expressed rhythmically in a 24 h rhythm. The central biological clock includes the suprachiasmatic nucleus, which rhythmically 'tunes' peripheral clocks (Figure 1) [1][2][3][4][5][6][7][8].Having the molecular basis of SCN being clarified the so-called core clock genes such as per1-2, cry1-2, bmal1 [9,10] and the demonstration that these genes are rhythmically expressed in peripheral tissues, including the liver, adrenal and pituitary glands [11][12][13], this central clock model is reshaped [14][15][16].Clock/Bmal, formed by the product of the genes circadian locomotor output cycles kaput [Clock] and brain and muscle aryl hydrocarbon receptor nuclear translocator like-Arntl (Bmal) represents the transcription initiator of the feedback loops [17].Clock/Bmal binds to E-box in the promoter regions of target genes Period homolog 1, 2 and 3 genes (Per1, Per2, Per3), Cryptochrome genes (Cry1, Cry2), retinoic acid-related orphan receptor (Rora, Rorb, Rorc) and Rev-Erb nuclear orphan receptor(Rev-Erbα, RevErbβ) to activate their expression [18,19].Transcription of Pers and Crys is initiated during the day, while degradation during the night. PER and CRY proteins enter the nucleus, probably as a multimeric complex (PER/CRY), and inhibit Clock/Bmal-mediated transcription [20,21].As to the role of the PER/CRY complex, Cryptochrome (CRY) is a blue-light sensor, which regulates neuronal firing rate, that is AbstractThe creation of a biological clock adjusted to way of life synchronizers influences the function of peripheral clocks and by extension, all physiological processes as well as secretion of hormones. Further, disturbance of the function of the biological clock exerts a strong impact on the pathogenesis of several disorders, including diabetes mellitus, insomnia, depression, cardiovascular disease and cancer, linking the pathophysiology of many diseases to one molecular mechanism, the 'out of tune clock'.Keywords: Diabetes mellitus; Pathogenesis; Suprachiasmatic nucleus; Cryptochrome circadian entrainment in Drosophila melanogaster [22]. Light activates CRY. When CRY is activated TIM [timeless] degrades, tuning the clock daily. In the absence of cry, the clock can still be activated by light, though the mechanisms are unclear; possibly, there are two types of clock neurons having differential sensitivities to light and temperature [23].With regard to the remainder feedback loop, the ROR/Bmal/RevErb (RBR) frames the original shape [20]. ROR acts as an activator of Bmal and Rev-Erb as an inhibitor which results in tuning of Bmal transcription [24,25]. Suppression of Rev-Erbα expression resulted in elevated Clock mRNA expression consistent with RevErbα's role as a transcriptional repressor, adding a regulation role of the activity of the Bmal1/Clock heterodimer by regulation of the expression of both the Bmal1 and Clock genes directly (Figure 2) [26]...

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“…кроме того, β-клетки не могут в течение длительного времени адекватно секретировать достаточное количество инсулина для ком-пенсации инсулинорезистентности, что также способствует гипергликемии. Подтверждают роль мелатонина в развитии гестационно-го сахарного диабета данные исследователей, установивших низкую секрецию мелатонина и отсутствие его суточного ритма во втором и третьем триместрах при данном осложнении беременности, что сочетается с нарушением засыпания, укорочением ночного сна и его ка-чественными особенностями [69,70]. Выявлено изменение при гестационном диабете продук-ции микроРНк (microRnAs), которая в норме имеет суточный ритм [71].…”

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The role of melatonin in development of gestational diabetes mellitus

et al. 2018

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This review summarizes many of the published reports about the production of melatonin and it’s role in regulation of carbohydrate metabolism, interrelationships between melatonin, insulin, glucagon and diurnal signaling the blood-glucose-regulating of the islet. The results of experimental and clinical investigations support that low melatonin levels and absence it’s circadian rhythm play the role in the development of gestational diabetes mellitus in womens with pathology of neuroimmunoendocrinology system and suggest the possibility of prognosis and prophylactic this complication of pregnancy.

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Salivary melatonin levels and sleep-wake rhythms in pregnant women with hypertensive and glucose metabolic disorders: A prospective analysis

Cited by 50 publications

References 42 publications

Regulatory mechanism of melatonin on the retinal ganglion cell photoreaction in mice

Regulatory mechanism of melatonin on the retinal ganglion cell photoreaction in mice

The Biological Clock and Vascular Disease: Application to Pregnancy

The role of melatonin in development of gestational diabetes mellitus

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