Salivary markers of oxidative stress are related to age and oral health in adult non‐smokers

Abstract

Age as a significant contributor to the variance should be taken into account in studies focusing on salivary markers of oxidative stress. The relationship between PBI and salivary TBARS confirms results from previous studies. In addition, our results show that the association is age independent. Negative association between the CI and AOPPs might be related to recent findings that AOPP might be actually a marker of non-enzymatic antioxidant status.

Periodontal condition, changes in salivary biochemical parameters, and oral health‐related quality of life in patients with anorexia and bulimia nervosa

“…Oxidative stress may be the result of an increase in free radical production or a decrease in protective antioxidant mechanisms . Although some studies have demonstrated an association between salivary markers of oxidative stress and periodontal status, no significant difference was observed in the salivary concentration of TBARSs among the groups in the present study . It is possible to suggest that this result is because of a compensatory effect of the antioxidant capacity of saliva, which involves the action of different mechanisms, such as antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, which are involved in the neutralization of free radicals …”

Salivary Lipid Peroxidation in Patients With Generalized Chronic Periodontitis and Acute Coronary Syndrome

“…Furthermore, findings on MDA levels were mostly obtained from serum and plasma. To the authors’ knowledge, only a few studies have focused on comparing MDA levels in the saliva of patients with periodontitis and controls 14,17,22‐28 . Moreover, although some of these studies showed significant differences in salivary MDA levels between patients with periodontitis and healthy controls or significant correlation between salivary MDA levels and periodontal parameters, 14,17,22,28 others did not 27 .…”

“…In the last decade, LPO was mainly investigated in patients with periodontitis to assess the role of OS in periodontal diseases 14‐17,22‐28 . A recent meta‐analysis showed that the conclusions of different studies on this subject remain controversial, possibly owing to study heterogeneity, such as design, sample size, and biomarker measurement methods 16 .…”

“…MDA belongs to the group of thiobarbituric acid–reacting substances and is a widely used biomarker for OS, 23–25 not only in the evaluation of periodontal disease, as previously mentioned, but also in CVDs such as CHD. It is believed that lipid and lipoprotein abnormalities play a major role in the development and progression of CHD, and atherosclerosis, the basis of CHD, is an inflammatory disorder 44 .…”

“…LPO is one of the major consequences of OS and can be evaluated by monitoring the levels of malondialdehyde (MDA), a product of breaking down long carbon strings of fatty acid 22–25 . Previously, MDA levels have been assessed in the plasma, serum, gingival crevicular fluid, and saliva of patients with periodontitis, 14‐17,22‐28 as well as in the plasma and serum of patients with CHD 29 , 30 . However, to the best of the authors’ knowledge, no studies have been conducted to monitor salivary MDA levels in patients with ACS.…”