Salivary malondialdehyde levels in clinically healthy and periodontal diseased individuals

J, Khalili; Biloklytska, G.

doi:10.1111/j.1601-0825.2008.01464.x

Cited by 56 publications

(53 citation statements)

References 35 publications

(37 reference statements)

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“…Our finding indicates higher serum MDA level in chronic periodontitis as compared to the healthy controls. Many researchers have also reported higher MDA levels in chronic periodontitis [45,46]. Smoking may enhance the effect of ROS in periodontitis, thereby increasing the tissue destruction resulting from oxidative stress, which may lead to higher lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

et al. 2013

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The present study aims to assess and compare the biochemical oxidative stress markers in male smokers and non-smokers with chronic periodontitis. One hundred thirty-four male chronic periodontitis patients and 64 apparently healthy male volunteers were recruited for the study. The periodontal status was evaluated by measuring gingival index, plaque index, papillary bleeding index and clinical attachment loss using UNC-15 probe. The biochemical markers estimated were total antioxidant capacity, RBC-superoxide dismutase, glutathione peroxidase, vitamin C, malondialdehyde and C-reactive protein.The obtained results indicate higher oxidative stress in chronic periodontitis. Smokers with chronic periodontitis show significantly higher periodontal clinical parameters and relatively higher systemic oxidative stress. Vitamin C estimation may be an important biochemical parameter in conjunction with clinical parameters for diagnosis of chronic periodontitis in smokers.

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Section: Discussionmentioning

confidence: 99%

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

et al. 2013

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“…An increased LPO level following periodontitis has been noted in many studies [6,8,42]. In addition to oxygen-derived free radicals, glycated collagen has also been shown to raise the oxidative breakdown of lipids compared to normal collagen which causes increased MDA in serum and tissues of diabetic subjects [24].…”

Section: Discussionmentioning

confidence: 99%

“…This has been shown to play a role in both infection and inflammatory response, and hence is considered as a key mediator in the pathogenesis of host destruction [5]. Among the several low molecular weight end products of lipid peroxidation (LPO) malondialdehyde (MDA) are most often measured as an index of peroxidation [6]. The levels of serum and salivary NO and MDA have been found to be increased in periodontitis and diabetes [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Non-Surgical Therapy on Salivary Nitric Oxide and Lipid Peroxidation Levels in Type Ii Diabetic and Non Diabetic Patients With Periodontal Disease

Latha

Uppoor

Nayak

et al. 2018

Asian J Pharm Clin Res

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Objective: Reactive oxygen species have been identified as potential factors causing periodontal tissue destruction. Elevated levels of these in patients with chronic periodontitis and diabetes may aggravate the oxidative stress burden thereby accelerating the tissue damage associated with diabetes. The present study aimed to assess the effect of diabetes and periodontal disease on the oxidative stress markers and the effect of non-surgical therapy on these markers.Methods: A total of 50 participants were divided into four groups based on the selection criteria. In addition to clinical parameters and biochemical parameters (salivary nitric oxide [NO] and malondialdehyde [MDA] levels) were assessed using spectrophotometric method at baseline and 3 months after non-surgical periodontal therapy.Result: There was a statistically significant difference in the clinical parameters as well as NO and MDA levels in patients with type 2 diabetes and chronic periodontitis than other three groups at baseline and at 3 months after non-surgical periodontal therapy. Conclusion:Diabetes mellitus and periodontitis have a compounding effect on the oxidative stress. Periodontal therapy is essential for diabetic patients as it can lower the levels of oxidative damage.

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“…Some Table 2 The levels of melatonin and oxidative stress parameters in the heart tissue (mean ± standard deviation) studies also indicate the relationship between severity of periodontal disease and MDA levels (14,(49)(50)(51), whereas others suggest that periodontal disease has a significant effect on ROS activity in systemic inflammatory conditions (39).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Özdem

Kırzıoğlu

Yilmaz

et al. 2017

Journal of Oral Science

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The aim of this study was to evaluate the effects of melatonin on the oxidative stress in heart tissues after induction of experimental periodontitis in rats. Thirty Wistar Albino male rats were divided into four groups as follows: healthy + saline solution (Hs, n = 7), healthy + melatonin (Hm, n = 7), periodontitis + saline solution (Ps, n = 8), and periodontitis + melatonin (Pm, n = 8). Experimental periodontitis was induced using a ligature placed at the gingival margin of the maxillary second molars. Melatonin was applied intraperitoneally (10 mg/ kg) every day for 2 weeks. After sacrificing the rats, serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) levels, and melatonin levels were evaluated. The Pm group exhibited lower alveolar bone loss than the Ps group. Melatonin levels increased in the periodontitis groups, and the Pm group had lower MDA levels and higher GSH-Px levels than the Ps group. These findings suggest that melatonin administration reduces MDA and increases GSH-Px levels in heart tissue, and these effects may be due to its antioxidant properties.Further studies are needed to understand the effects of melatonin on the association between periodontitis and cardiovascular disease.

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Salivary malondialdehyde levels in clinically healthy and periodontal diseased individuals

Abstract: Increased MDA levels are with closely associated with the severity and patients status of periodontal disease that has not been previously reported. The detection of salivary MDA level may provide additional advantages in elucidating the pathogenesis of periodontal disease.

Cited by 56 publications

References 35 publications

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

Effect of Non-Surgical Therapy on Salivary Nitric Oxide and Lipid Peroxidation Levels in Type Ii Diabetic and Non Diabetic Patients With Periodontal Disease

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

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