Salivary-Like Tumors of the Thyroid: A Comprehensive Review of Three Rare Carcinomas

Chambers, Meagan; Nosé, Vânia; Sadow, Peter M.; Tafe, Laura J.; Kerr, Darcy A.

doi:10.1007/s12105-020-01193-5

Cited by 11 publications

(15 citation statements)

References 83 publications

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“…TTF‐1 and PAX8 expression are variable, thyroglobulin is negative 2,15 . Mucicarmine highlights intracellular mucin 2,15 . Our case demonstrated an immunoprofile consistent with the literature.…”

Section: Discussionsupporting

confidence: 86%

“…Chan et al described a subset of MEC with unique features as sclerosing mucoepidermoid carcinoma with stromal eosinophilia 1 . SMECE has a characteristic histologic picture with tumor cells with squamous and mucinous differentiation extensive sclerotic stroma, with abundant eosinophils and chronic inflammation 1,2,6,14 . SMECE occurs predominantly in women with a background of chronic lymphocytic thyroiditis 1,2,15 .…”

Section: Discussionmentioning

confidence: 99%

“…SMECE has a characteristic histologic picture with tumor cells with squamous and mucinous differentiation extensive sclerotic stroma, with abundant eosinophils and chronic inflammation 1,2,6,14 . SMECE occurs predominantly in women with a background of chronic lymphocytic thyroiditis 1,2,15 . For the most part SMECE has been classified as a low‐grade tumor with an indolent course 4,14,16‐19 …”

Section: Discussionmentioning

confidence: 99%

“…SMECE routinely expresses squamous markers, such as p63 and p40 2,14,15,21 . TTF‐1 and PAX8 expression are variable, thyroglobulin is negative 2,15 . Mucicarmine highlights intracellular mucin 2,15 .…”

Section: Discussionmentioning

confidence: 99%

“…Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) was first described as a distinct entity from mucoepidermoid carcinoma (MEC) in 1991 by Chan et al 1 Since that description, approximately 56 cases of SMECE have been reported with descriptions of histology 2 . Despite most thyroid nodules having been initially evaluated by fine‐needle aspiration (FNA), there are only 11 cases with descriptions of cytomorphology 3‐13 .…”

Section: Introductionmentioning

confidence: 99%

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Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia in conjunction with parotid basal cell adenoma: Cytologic, histologic, and molecular features

Noor

Russell

Israel

et al. 2021

Diagnostic Cytopathology

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Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a rare malignancy in the thyroid: only 56 cases with histologic descriptions are reported in the literature and fewer reports describe the cytomorphology. Given the rarity of SMECE, data on the cytomorphologic and molecular features are limited. We report a case of a 53‐year‐old woman with a 5 cm left thyroid mass. Fine‐needle aspiration (FNA) revealed atypia of undetermined significance and pathology of left thyroid lobectomy specimen showed SMECE. Additionally, a left pre‐auricular lump was noted and FNA followed by left superficial parotidectomy showed basal cell adenoma. Next‐generation sequencing showed point mutations in NTRK3 and NF1. Unlike salivary gland mucoepidermoid carcinoma, MAML2 translocations are not present in SMECE. Even though it is a rare entity, awareness of SMECE of the thyroid is important. In this case report we review the cytomorphologic, histologic, and molecular features.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%