Salivary levels of vascular endothelial growth factor (VEGF) in recurrent aphthous ulceration

Brozović, Suzana; Vučićević-Boras, Vanja; Stipetić, Marinka Mravak; Jukić, Silvana; Kleinheinz, J.; Lukač, Josip

doi:10.1034/j.1600-0714.2002.310208.x

Cited by 31 publications

(33 citation statements)

References 11 publications

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“…The concentrations observed for all the CCGFs from three different samples in this work cannot be compared with the published data for several reasons: (a) not enough published data is available to compare all 48 CCGFs studied in this work; (b) only limited data is available on the concentrations of some CCGFs measured from multiple body fluids of the same subjects; (c) various techniques were used in each report and there may be some sensitivity differences between techniques; and (d) age, gender and ethnicity differences between subjects in various reports. Nevertheless, the concentrations obtained in this work for IL-13, VEGF, IL-1beta, IL-12p70, and IL-10, MCP-1 are comparable with healthy controls as reported [18,47,53,56].…”

Section: Discussionsupporting

confidence: 92%

Detection and quantitation of forty eight cytokines, chemokines, growth factors and nine acute phase proteins in healthy human plasma, saliva and urine

Khan¹

2012

Journal of Proteomics

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Section: Discussionsupporting

confidence: 92%

Detection and quantitation of forty eight cytokines, chemokines, growth factors and nine acute phase proteins in healthy human plasma, saliva and urine

Khan¹

2012

Journal of Proteomics

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“…EGF was found to increase the secretion and mRNA expression of VEGF in certain cell lines in vitro [26]. Although it is not known if the same holds true for the oral mucosa, reduced salivary VEGF levels were found in acute major RAS [11]. VEGF is considered to play an essential role in the inflammation and pathogenesis of vasculitic processes [10, 26].…”

Section: Discussionmentioning

confidence: 99%

“…Immunopathogenetic studies indicate that these ulcerations might be caused by cytotoxic action of lymphocytes and monocytes on the oral epithelium with an unknown trigger. Immunologic and/or cytokine aberration leading to local tissue destruction have also been implicated [2,3,4,6,7,8,9,10,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Salivary Epidermal Growth Factor Levels in Behçet’s Disease and Recurrent Aphthous Stomatitis

Adışen¹,

Aral

Aybay

et al. 2008

Dermatology

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Background: Epidermal growth factor (EGF) in saliva is cytoprotective against injuries and contributes to the maintenance of the integrity of the gastrointestinal mucosa. Low salivary EGF levels have been observed in patients with various forms of oral mucosal disease. Objective: Our aim wasto determine whether salivary EGF is low in patients with recurrent aphthous stomatitis (RAS) or those with Behçet’s disease (BD) when compared with healthy controls. Methods: The study population consisted of 33 BD and 16 RAS patients and 60 healthy controls. Measurement of EGF concentration in human saliva was performed with an enzyme-linked immunosorbent assay using an antibody-coated solid phase. Results: The mean salivary EGF levels (±SD) of active (with oral ulceration) and inactive stages (absence of oral ulceration) of BD (1,939.7 ± 1,561.5 and 2,305.7 ± 1,481.6 pg/ml, respectively) and RAS patients (1,650.5 ± 704.7 and 1,069.9 ± 539.2 pg/ml, respectively) were both lower than those of the healthy controls (2,758.7 ± 1,657.9 pg/ml) (p < 0.05 for each). Conclusions: BD and RAS patients have reduced salivary EGF levels even in the absence of oral ulcerations. EGF could be involved in the pathogenesis of BD and RAS by disturbing the mucosal integrity that may result in a susceptibility to the development of oral ulcers in these diseases.

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“…Genetic predisposition [4] [5] [6]; Immunological abnormalities [7]- [13]; Hematological abnormalities [14] [15] Infectious causes [16] [17] [18]; Hormonal factors [19] [20]; Smoking [21] [22] [23]; Trauma [1]; Stress [24]; and Food allergies [19].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Recurrent Aphthous Stomatitis by 100% Topical Pumpkin Seed Oil

Sharquie¹,

Noaimi²,

Latif³

2017

JCDSA

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Background: Recurrent aphthous stomatitis (RAS) is a major oral health problem, where its etiopathogenesis is not well understood. Accordingly, its therapy whether topical or systemic can induce clearance, but the relapse rate is high. Objective: To use 100% topical pumpkin seed oil in RAS as it has many actions as anti-inflammatory and antioxidant effects. Patients and Methods: This single, blind, clinical, therapeutic trial was conducted in the Department of Dermatology-Baghdad Teaching Hospital, Baghdad, Iraq, during February 2015-August 2016. Twenty-five patients with RAS were included in this work. After full history and clinical examination, the clinical diagnosis was established. Oral clinical manifestation index score (OCMI) was carried out before, during and after stopping therapy to assess the different parameters of this score. 100% Topical pumpkin seed oil was given two times daily for 3 months during which short term assessment for each patient was done by using OCMI before, after 4 days and after 8 days of therapy in addition to assessing the mean size of largest diameter of ulcers in each visit to evaluate the therapeutic efficacy of the therapy, while long term assessment of the OCMI was done every month for 3 months after starting of the therapy to evaluate the prophylactic effect of the therapy. After 3 months, pumpkin seed oil was stopped and assessment of OCMI was done monthly for another 3 months to evaluate the remission action of pumpkin seed oil. Results: Twenty-five patients were included in this study: 15 (60%) males and 10 (40%) females. While their ages ranged from 9 -60 (27.48 ± 11.97) years. The mean of OCMI before pumpkin seed oil therapy was ranged from 9 -15 (12.96 ± 1.42), while after the therapy the mean started to decline to lower level within 4 days of therapy and was statistically significant (p < 0.0001) and continued to decline significantly till the end of third month of therapy (p < 0.0001). The percent reduction was 79.30% after 4 days of therapy and 94.38% after 8 days of therapy. After stopping therapy, the mean of OCMI started to increase, but it is remained statistically highly significant (p < 0.0001) at the end of third months after stopping therapy when it is compared with baseline mean of OCMI. Conclusion: Pumpkin seed oil had an effective therapeutic and prophylactic action against RAS, in addition, it induced remission for at least 3 months after stopping therapy. No local or systemic side effects were observed during the course of therapy.

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Salivary levels of vascular endothelial growth factor (VEGF) in recurrent aphthous ulceration

Abstract: Salivary VEGF levels seemed to be associated with ulcer development in major RAU, showing stage-dependent alterations during the course of this disorder.

Cited by 31 publications

References 11 publications

Detection and quantitation of forty eight cytokines, chemokines, growth factors and nine acute phase proteins in healthy human plasma, saliva and urine

Detection and quantitation of forty eight cytokines, chemokines, growth factors and nine acute phase proteins in healthy human plasma, saliva and urine

Salivary Epidermal Growth Factor Levels in Behçet’s Disease and Recurrent Aphthous Stomatitis

Treatment of Recurrent Aphthous Stomatitis by 100% Topical Pumpkin Seed Oil

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