Salivary levels of inflammatory cytokines and their association to periodontal disease in systemic lupus erythematosus patients. A case-control study

Marques, Consuelo Penha Castro; Victor, Elis Cabral; Franco, Mayra Moura; Fernandes, José Mauro Carneiro; Maor, Yehoshua; Andrade, Marcelo Souza de; Rodrigues, Vandílson Pinheiro; Benatti, Bruno Braga

doi:10.1016/j.cyto.2016.06.025

Cited by 38 publications

(42 citation statements)

References 43 publications

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“…The salivary IFN γ concentration in control volunteers in this study was found to be similar to that obtained by Marques et al . 46 , also stimulated saliva. The concentration of TNF-α in stimulated saliva from control volunteers correlated well with data from other studies 47 .…”

Section: Discussionmentioning

confidence: 89%

Modulation of salivary cytokines in response to alcohol, tobacco and caffeine consumption: a pilot study

Sheth

López‐Pedrajas

Jovani-Sancho

et al. 2018

Sci Rep

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It has been shown that long-term stimulant consumption alters the biological and microbiological status of the oral cavity. We present a pilot study describing stimulant-specific oral immunomodulation in the oral cavity. Changes in salivary cytokine levels in response to long-term alcohol, tobacco and caffeine were identified. Volunteers were recruited from amongst the patients visiting University Dental Clinic of CEU Cardenal Herrera University (Alfara del Patriarca, Spain). Participants were grouped according to their self-reported levels of consumption of either caffeine, alcohol or tobacco (control group volunteers were non-consumers of all three). Informed consent was provided and stimulated saliva samples were obtained and assayed for interleukin-1α IL-1α), Tumor Necrosis Factor α (TNF-α) and Interferon γ IFN-γ). Long-term, high-level consumers of alcohol or tobacco exhibited elevated salivary concentrations of the three inflammatory cytokines with respect to control values. Specifically, IL-1α was found to be elevated in alcohol users whilst IFN-γ concentration higher in tobacco users versus controls. Long-term caffeine consumers displayed elevated levels of IFN-γ and TNF-α, whereas IL-1α levels were reduced with respect to control volunteers. This pilot study demonstrates that salivary cytokines can be modulated in response to quantity and duration of alcohol, caffeine or tobacco consumption.

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Section: Discussionmentioning

confidence: 89%

Modulation of salivary cytokines in response to alcohol, tobacco and caffeine consumption: a pilot study

Sheth

López‐Pedrajas

Jovani-Sancho

et al. 2018

Sci Rep

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“…Genetic variants in the Fcy receptor have been implicated in susceptibility to both SLE and periodontitis in a small Japanese study ( 32 ). Periodontitis and SLE are both inflammatory conditions, and share similar inflammatory profiles ( 33 , 34 ). Specifically, a possible role for TLR-4 has been implicated.…”

Section: Discussionmentioning

confidence: 99%

Association between Systemic Lupus Erythematosus and Periodontitis: A Systematic Review and Meta-analysis

et al. 2017

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BackgroundSystemic lupus erythematosus (SLE) is a chronic systemic inflammatory autoimmune disease, the etiology of which remains only partially characterized. Strong evidence implicates chronic infections in the development and chronicity of autoimmune conditions. Recently, an association has been demonstrated between periodontitis and rheumatoid arthritis. Such observations have led to the investigation of the possible role of periodontitis and oral dysbiosis in other systemic inflammatory conditions, including SLE. The aim of this study was to examine whether there is an association between SLE and periodontitis.MethodsMEDLINE via OVID, EMBASE via OVID, and PsycINFO via OVID databases were searched to identify eligible studies, screened by two independent authors and verified by a third. Studies comparing presence of periodontitis in SLE cases to controls without SLE were included. Data were extracted using a predefined table and papers were appraised using Down’s and Black tool. Mantel–Haenszel meta-analysis was performed using RevMan.ResultsEight case–control studies were included, with 487 SLE cases and a total of 1,383 participants. On meta-analysis of four studies, risk of periodontitis in SLE cases compared to controls was significantly greater with a risk ratio of 1.76 (95% CI 1.29–2.41, p = 0.0004). No statistical difference was found in individual measures of periodontitis, such as probing depth or clinical attachment loss, between SLE cases and controls.ConclusionOur study found a statistically significant increased risk of periodontitis in patients with SLE compared to controls. This finding suggests a possible association between these two conditions. Larger longitudinal studies are needed to confirm this possible association.

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“…However, data about such salivary cytokines (TNF-β, IL-2, IL-4, and IL-13) in alcohol users were not found. A previous study with alcohol users assessed differences in salivary concentrations of TNF-α, IL-1α, and INF-γ compared to controls, showing significantly increased expression of all cytokines in alcohol users [100]. To the best of our knowledge, data from the current study provides new evidence identifying potential salivary biomarkers associated with alcohol use.…”

Section: Discussionmentioning

confidence: 63%

Inflammatory Biomarkers, Microbiome, Depression, and Executive Dysfunction in Alcohol Users

Rodríguez-Rabassa

López

Sánchez

et al. 2020

IJERPH

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Alcohol-related disorders (ARD) are highly prevalent among Latin American-Caribbean countries. Mental disorders are common comorbidities in individuals with ARD. However, the etiology of the association between ARD and mental disorders remains unclear. We examined the association of inflammatory cytokines, microbiome, and other biomakers with measures of depression, social anxiety, and executive functions. We observed a significant increase in cytokine and chemokine expression levels in saliva and plasma in the alcohol group (AG) samples. Also, the salivary bacterial composition in the AG revealed an abundance of Prevotella. Depression symptomatology was markedly higher in the AG, but social anxiety levels were negligible. AG also exhibited executive dysfunctions, which negatively correlated with increased plasma levels of pro-inflammatory cytokines and increased salivary concentrations of Prevotella bacteria. Our study suggests that chronic alcohol use correlates with executive dysfunction, immune system dysregulation, and dysbiosis of the salivary microbiota. Additional studies are needed to understand the role of the microbiome and inflammation in alcohol use and mental comorbidities.

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Salivary levels of inflammatory cytokines and their association to periodontal disease in systemic lupus erythematosus patients. A case-control study

Cited by 38 publications

References 43 publications

Modulation of salivary cytokines in response to alcohol, tobacco and caffeine consumption: a pilot study

Modulation of salivary cytokines in response to alcohol, tobacco and caffeine consumption: a pilot study

Association between Systemic Lupus Erythematosus and Periodontitis: A Systematic Review and Meta-analysis

Inflammatory Biomarkers, Microbiome, Depression, and Executive Dysfunction in Alcohol Users

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