Salivary Levels of ErbB2 and CEA in Oral Squamous Cell Carcinoma Patients

Honarmand, Marieh; Farhad-Mollashahi, Leila; Nakhaee, Alireza; Nehi, Masoume

doi:10.7314/apjcp.2016.17.s3.77

Cited by 17 publications

(15 citation statements)

References 13 publications

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“…In another study, immunoglobulins were detected at higher levels in OSCC patients as compared to controls and found to be involved in angiogenesis [60]. A similar observation was reported for several cell surface receptor glycoproteins, namely CD44, CD59 and CEA, which were found overexpressed in patients with OSCC [61]. Different zinc finger proteins were also found augmented in OSCC patients, namely ZNF510 [62] or Cyfra 21-1 and CK 19 [61][62][63].…”

Section: Oral Cancersupporting

confidence: 64%

Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review

et al. 2020

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Fostered by the advances in the instrumental and analytical fields, in recent years the analysis of volatile organic compounds (VOCs) has emerged as a new frontier in medical diagnostics. VOCs analysis is a non-invasive, rapid and inexpensive strategy with promising potential in clinical diagnostic procedures. Since cellular metabolism is altered by diseases, the resulting metabolic effects on VOCs may serve as biomarkers for any given pathophysiologic condition. Human VOCs are released from biomatrices such as saliva, urine, skin emanations and exhaled breath and are derived from many metabolic pathways. In this review, the potential of VOCs present in saliva will be explored as a monitoring tool for several oral diseases, including gingivitis and periodontal disease, dental caries, and oral cancer. Moreover, the analytical state-of-the-art for salivary volatomics, e.g., the most common extraction techniques along with the current challenges and future perspectives will be addressed unequivocally.

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Section: Oral Cancersupporting

confidence: 64%

Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review

et al. 2020

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“…Table 1 presents the descriptive characteristics of the 14 included studies in the meta-analysis. [4][5][6][7][8][9][10][11][12][13][14][15][16][17] The different salivary biomarkers analyzed in different population groups (patients with OSCC, patients with oral potentially malignant disorders, and controls) are shown in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies [13][14][15] analyzed the salivary levels of the carcinoembryonic antigen (CEA) in OSCC patients and controls. OSCC patients had higher levels of CEA with a statistically significant association (DM: 22.80, 95% CI: 5.46-40.14, P = 0.01).…”

Section: Resultsmentioning

confidence: 99%

“…ET-1 ET-1 can be used as a biomarker for OPMD and OSCC lesions He et al [13] 2009 China 80 OSCC, 57.0 yr, 52M/28F 80 controls, 37.0 yr, 42M/38F CEA Salivary CEA level can be useful as prognostic indicator in early diagnosis of OSCC Honarmand et al [14] 2016 Iran 27 OSCC, 53.8 yr, 15M/12F 26 controls, 52.8 yr, 14M/12F CEA Salivary CEA levels may be useful for the early detection of OSCC…”

Section: Discussionmentioning

confidence: 99%

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Usefulness of salivary biomarkers in oral precancer and cancer

Rodríguez-Archilla¹,

Carrion-Ruiz²

2018

IDJAR

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Background: Oral and pharyngeal cancer is the sixth most common cancer in the world. Tumoral biomarkers are important for the early diagnosis of oral cancer and to establish prognostic criteria for these lesions. Aim: The aim of this study is to assess the possible influence of salivary biomarkers on potentially malignant and malignant oral lesions. Methodology: A PubMed search through April 2018, using the following Medical Subjects Headings terms, was performed: "Mouth neoplasms," "biomarkers," and "saliva." Studies with findings on several salivary biomarkers on potentially malignant and malignant oral lesions were comprised. A total of 180 articles (156 of them fulltext articles) were found. 142 articles were excluded for several reasons: Different measurement units/detection methods (95), studies with no usable data (34), studies with no oral cancer patients group (7), and studies about malignant salivary gland tumors (6). For continuous outcomes, the estimates of effects of an intervention were expressed as mean differences (MD) using the inverse variance method together with 95% confidence intervals. Results: Fourteen studies on salivary biomarkers on potentially malignant and malignant oral lesions were included in this meta-analysis. Biomarkers with significant diagnostic and prognostic relevance in oral cancer were as follows: Interleukin 8 (IL-8) (P < 0.001), endothelin 1 (P < 0.001), IL-6 (P < 0.001), cytokeratin fraction 21-1 (P < 0.001), and carcinoembryonic antigen (P = 0.01). Conclusion: Salivary biomarkers have a important relevance in oral cancer. In the case of potentially malignant oral disorders, their relevance seems less evident. Clinical Significance: Saliva is an useful fluid to identify possible diagnostic and prognostic biomarkers in oral cancer.

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“…On the other hand, different investigations mainly based on Western blot, or MRS-based targeted proteomics techniques have found cell-surface glycoproteins overexpressed in patients with OSCC such as CD44, CD59, or CEA. Other biomarkers related to the zinc finger protein family (ZNF) such as ZNF510, Cyfra 21-1, and CK19 have also been reported [ 153 – 155 ]. In this sense, Jou et al reported a sensitivity and specificity greater than 95% for salivary ZNF510 in the discrimination of tumors in early stages (T1 + T2) vs. advanced stages (T3 + T4) [ 156 ].…”

Section: The Salivary Proteome In the Health-illness Spectrummentioning

confidence: 99%

Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases

et al. 2018

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The Global Burden of Oral Diseases affects 3.5 billion people worldwide, representing the number of people affected by the burden of untreated dental caries, severe periodontal disease, and edentulism. Thus, much more efforts in terms of diagnostics and treatments must be provided in the fight of these outcomes. In this sense, recently, the study of saliva as biological matrix has been identified as a new landmark initiative in the search of novel and useful biomarkers to prevent and diagnose these conditions. Specifically, saliva is a rich reservoir of different proteins and peptides and accessible due to recent advances in molecular biology and specially in targeted and unbiased proteomics technologies. Nonetheless, emerging barriers are an obstacle to the study of the salivary proteome in an effective way. This review aims at giving an overall perspective of salivary biomarkers identified in several oral diseases by means of molecular biology approaches.

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Salivary Levels of ErbB2 and CEA in Oral Squamous Cell Carcinoma Patients

Cited by 17 publications

References 13 publications

Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review

Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review

Usefulness of salivary biomarkers in oral precancer and cancer

Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases

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