Salivary interleukin-1β: Oral inflammatory biomarker in patients with psoriasis

Ganzetti, Giulia; Campanati, Anna; Santarelli, Andrea; Molinelli, Elisa; Brisigotti, Valerio; Ruscio, Giulia Di; Bobyr, Ivan; Emanuelli, Monica; Offidani, Annamaria

doi:10.1177/0300060515598902

Cited by 16 publications

(9 citation statements)

References 23 publications

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“…The studies had been Dermatology Review/Przegląd Dermatologiczny 2021/2 published from 1973 to 2016. Two studies were reported from England [18,19], 2 from Italy [20,21], two from Germany [22,23], and 1 from each of the following countries: France [24], Finland [25], Japan [26], Israel [27], Bulgaria [28], Syria [29], the Netherlands [30], and Iran [6].…”

Section: Resultsmentioning

confidence: 99%

“…Prace zostały opublikowane od 1973 do 2016 roku. Zbiór obejmował po dwa badania z Wielkiej Brytanii [18,19], Włoch [20,21] i Niemiec [22,23] oraz po jednym z Francji [24], Finlandii [25], Japonii [26], Izraela [27], Bułgarii [28], Syrii [29], Holandii [30] i Iranu [6]. stężenia α-amylazy, kortyzolu, igA i interleukiny 1b w ślinie Analizę zbiorczą stężeń α-amylazy, kortyzolu, IgA i interleukiny 1b w ślinie przedstawiono na rycinie 2.…”

Section: Resultsunclassified

“…The results of 3 studies [18,24,25] showed a significantly increased level in psoriatic compared to controls. Examining interleukin-1b in 2 studies [20,21], both reported a significantly increased level in the patients compared to controls. Candida incidence was investigated in 2 studies [6,27], both of which showed a significant incidence in psoriatic patients compared with controls.…”

Section: Discussionmentioning

confidence: 99%

“…Wyniki trzech badań [18,24,25] wykazały znamiennie podwyższone stężenie IgA u chorych na łuszczycę w stosunku do grupy kontrolnej. Interleukinę 1b analizowano w dwóch badaniach [20,21]. W obu stwierdzono znamienny wzrost jej stężenia u pacjentów z łuszczycą w porównaniu z grupą kontrolną.…”

Section: Discussionunclassified

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Salivary biomarkers in patients with psoriasis – a meta-analysis

Nemati¹,

Sadeghi²

2021

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Introduction. Psoriasis is a chronic, inflammatory cutaneous disease with an unclear aetiology. Several biomarkers have been investigated for their significance in clinical practice. Objective. This meta-analysis aimed to evaluate the salivary biomarkers in psoriatic patients compared to controls. Material and methods. The PubMed, Scopus, Web of Science, and Cochrane Library databases were searched from the beginning of each database. The mean differences (MDs) or odds ratios (ORs) with 95% confidence intervals (CIs) in all studies were analysed using Review Manager 5.3 software. Results. Fourteen studies were analysed in the meta-analysis. Investigating salivary α-amylase, cortisol, IgA, interleukin-1b, candida incidence, antipyrine clearance, sodium, potassium, chloride, and flow rate levels, there was a significant difference between psoriatic patients and controls in α-amylase (MD = 12.69 IU/ml), interleukin-1b (MD = 1.60 pg/ml), and candida incidence (OR = 7.64), respectively. Some salivary biomarkers such as α-amylase, interleukin-1b, and candida incidence were significantly higher in the patients with psoriasis than in the controls. Conclusions. The results indicate that saliva analysis is a valid noninvasive tool which may be used to monitor inflammation in psoriasis. streszczenie Wprowadzenie. Łuszczyca jest przewlekłą chorobą zapalną skóry. Wiele biomarkerów łuszczycy analizowano pod względem ich potencjalnej przydatności w praktyce klinicznej. Cel pracy. Ocena biomarkerów obecnych w ślinie u pacjentów z łuszczycą w porównaniu z grupą kontrolną. Materiał i metody. Przeszukano bazy danych PubMed, Scopus, Web of Science i Cochrane Library. Średnie różnice (mean difference -MD) lub ilorazy szans (odds ratio -OR) wraz z 95% przedziałami ufności (confi-

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Section: Resultsmentioning

confidence: 99%

Section: Resultsunclassified

Section: Discussionmentioning

confidence: 99%

Section: Discussionunclassified

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Salivary biomarkers in patients with psoriasis – a meta-analysis

Nemati¹,

Sadeghi²

2021

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“…Furthermore, the association between psoriasis and oral mucosa could be indicated by the increased salivary [ 27 ] and serum levels of TGF- β 1 and MCP-1 in psoriasis patients [ 39 , 40 ]. In a different investigation, Ganzetti and coworkers confirmed the validity of saliva as a noninvasive tool to monitor inflammation in psoriasis [ 41 ]. At baseline, psoriasis patients had higher salivary levels of IL-1 β , evaluated via an enzyme-linked immunosorbent assay (ELISA), in comparison to healthy individuals.…”

Section: Saliva and Correlated Biomarkers In Psoriasismentioning

confidence: 99%

Saliva as a Future Field in Psoriasis Research

Asa’ad

Fiore

Alfieri

et al. 2018

BioMed Research International

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Psoriasis is a skin inflammatory disease characterized by an increased body of comorbidities, including parodontopathy. Despite the visibility of skin lesions, prognostic biomarkers, related to disease monitoring and therapeutic effectiveness, are still missing. Although several markers have been studied, none of them has been identified as an independent prognostic factor. This concise review aims to summarize the current knowledge and results in saliva research applied to psoriasis. Combination of different markers could improve the prognostic prediction in patients with psoriasis. Future studies are needed to implement research on salivary biomarkers and their prognostic/therapeutic effects in the management of patients with psoriasis.

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Hyposalivation in patients with psoriasis: Association with severity, inflammatory, and anti‐inflammatory cytokine biomarkers of the disease

Sharma,

Mahendra

et al. 2024

Biotech and App Biochem

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The aim of the study is to expound the effect of psoriasis on salivary glands by evaluating the secretion of saliva and salivary cytokine biomarkers in patients with psoriasis. This study was conducted by recruiting 120 subjects that included 60 patients diagnosed clinically with active psoriasis and 60 healthy controls who were age and gender matched to psoriatic subjects. Unstimulated whole saliva was collected from all the subjects by spitting method, and levels of tumor necrosis factor‐alpha (TNF‐α), interferon‐gamma (IFN‐γ), interleukin‐2 (IL‐2), and IL‐10 (IL‐10) were determined via enzyme‐linked immunosorbent assay (BT Lab, Shanghai, China). Secretion of saliva in psoriasis patients was considerably reduced than in healthy controls. The concentrations of pro‐inflammatory cytokines (TNF‐α, IFN‐γ, and IL‐2) were significantly increased, whereas level of anti‐inflammatory cytokine (IL‐10) was markedly decreased in the saliva of psoriasis patients with hyposalivation compared to healthy subjects. Our results demonstrated significant negative correlation of salivary flow rates with the disease severity. No significant correlations were obtained between salivary levels of tested cytokines and salivary flow rates in our study. Findings of the study reflect inflammation of salivary glands with reduced salivary flow rates in psoriasis patients. The inflammatory responses in salivary gland tissues by virtue of increased pro‐inflammatory cytokines concentrations together with lower anti‐inflammatory cytokine levels may have a role in affecting the saliva secretion in psoriasis patients. Secretion of unstimulated saliva in psoriasis patients decreases with the severity and duration of the disease.

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Salivary interleukin-1β: Oral inflammatory biomarker in patients with psoriasis

Cited by 16 publications

References 23 publications

Salivary biomarkers in patients with psoriasis – a meta-analysis

Salivary biomarkers in patients with psoriasis – a meta-analysis

Saliva as a Future Field in Psoriasis Research

Hyposalivation in patients with psoriasis: Association with severity, inflammatory, and anti‐inflammatory cytokine biomarkers of the disease

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