Salivary IL-6 Concentration Is Associated with Frailty Syndrome in Older Individuals

Gómez-Rubio, Pablo; Trapero, Isabel; Cauli, Omar; Buigues, Cristina

doi:10.3390/diagnostics12010117

Cited by 9 publications

(4 citation statements)

References 73 publications

(87 reference statements)

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“…In well-functioning older patients, IL-6 is found to be prospectively associated with cognitive decline. 39–41 IL-6 is also part of the core panel of frailty biomarkers 42 and has recently been suggested by Gómez-Rubio et al 43 as a useful biomarker for monitoring treatment in frail individuals. Both the proinflammatory action of IL-6 and its association with the risk factors that were discussed earlier are further pieces of evidence that lend credence to the neuroinflammatory hypothesis of delirium.…”

Section: Discussionmentioning

confidence: 99%

Proteomics for the Discovery of Clinical Delirium Biomarkers: A Systematic Review of Major Studies

Wiredu

Aduse-Poku

Shaefi

et al. 2022

Anesthesia &Amp; Analgesia

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Delirium represents a significant health care burden, diagnosed in more than 2 million elderly Americans each year. In the surgical population, delirium remains the most common complication among elderly patients, and is associated with longer hospital stays, higher costs of care, increased mortality, and functional impairment. The pathomechanism of disease is poorly understood, with current diagnostic approaches somewhat subjective and arbitrary, and definitive diagnostic biomarkers are currently lacking. Despite the recent interest in delirium research, biomarker discovery for it remains new. Most attempts to discover biomarkers are targeted studies that seek to assess the involvement of one or more members of a focused panel of candidates in delirium. For a more unbiased, system-biology view, we searched literature from Medical Literature Analysis and Retrieval System Online (MEDLINE), Cochrane Central, Web of Science, SCOPUS, and Dimensions between 2016 and 2021 for untargeted proteomic discovery studies for biomarkers of delirium conducted on human geriatric subjects. Two reviewers conducted an independent review of all search results and resolved discordance by consensus. From an overall search of 1172 publications, 8 peer-reviewed studies met our defined inclusion criteria. The 370 unique perioperative biomarkers identified in these reports are enriched in pathways involving activation of the immune system, inflammatory response, and the coagulation cascade. The most frequently identified biomarker was interleukin-6 (IL-6). By reviewing the distribution of protein biomarker candidates from these studies, we conclude that a panel of proteins, rather than a single biomarker, would allow for discriminating delirium cases from noncases. The paucity of hypothesis-generating studies in the peer-reviewed literature also suggests that a system-biology view of delirium pathomechanisms has yet to fully emerge.

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Section: Discussionmentioning

confidence: 99%

Proteomics for the Discovery of Clinical Delirium Biomarkers: A Systematic Review of Major Studies

Wiredu

Aduse-Poku

Shaefi

et al. 2022

Anesthesia &Amp; Analgesia

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“…A study on the transition from frailty to depressive symptoms in older adults in Korea found that the transition of frailty in older adults was related to depressive symptoms [50]. One of the physiological changes associated with frailty is an increase in the levels of the inflammatory cytokine interleukin 6 (IL-6) [51]. IL-6 is a cytokine with multiple effects on inflammation, immune responses, and hematopoietic blood [52].…”

Section: Discussionmentioning

confidence: 99%

Relationship between prevalence of cardiometabolic diseases, self-reported memory loss, and self-reported depressed mood of older adults in Korea according to frailty and physical activity status

2024

Journal of Men's Health

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As the older population increases worldwide, frailty is the area of research that deserve further investigation and is considered a major social and public health concern. Frailty appears physically and mentally, and recently, the term cognitive frailty has been used to combine physical frailty and mild cognitive impairment syndrome. Frailty in older adults is characterized by low physical activity levels and a sedentary lifestyle. Physical activity is essential in managing mental health issues such as depression and can improve the executive function and memory of older adults with mild cognitive impairment. Therefore, this study aimed to examine the prevalence of cardiometabolic diseases, self-reported memory loss, and depression among older adults in Korea according to frailty and physical activity status. Using data from the 2019 Korea National Health and Nutrition Survey, this study analyzed 613 community-dwelling older males aged ≥65 years. Physical activity was measured using a Global Physical Activity Questionnaire. A health-related quality of life instrument with eight items (HINT-8) was used to assess self-reported memory loss and depressed mood. Relationships between physical activity levels, self-reported memory loss and depressed mood were analyzed using logistic regression. The incidence of HINT-8 memory (0.52 (95% confidence interval (CI): 0.32–0.85)) was significantly lower in the Physical Activity Level (PAL)-high/pre-frail; the incidence of HINT-8 depression (0.35 (95% CI: 0.21–0.59); 0.29 (95% CI: 0.17–0.52)) was significantly lower in the and PAL-high/pre-frail. We verified that the group with PAL-low/frail had the highest self-reported memory loss and depressed mood, suggesting that more physical activity may reduce self-reported memory loss and depressed mood among frail older males in Korea. However further research is needed to analyze the level of physical activity separately between work and leisure.

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“…In well-functioning older patients, IL-6 is found to be prospectively associated with cognitive decline 39-41 . IL-6 is also part of the core panel of frailty biomarkers 42 , and has recently been suggested by Gómez-Rubio, Trapero, Cauli, Buigues 43 as a useful biomarker for monitoring treatment in frail individuals. The inflammatory role of IL-6 and its associations with aforementioned predisposing triggers further emphasize the neuro-inflammatory model of delirium.…”

Section: Discussionmentioning

confidence: 99%

Proteomics for the discovery of clinical delirium biomarkers: A systematic review of Major Studies

Wiredu

Aduse-Poku

Shaefi

et al. 2022

Preprint

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Delirium represents a significant healthcare burden, diagnosed in over two million elderly Americans each year. In the surgical population, delirium remains the most common complication among elderly patients and is associated with longer hospital stays, higher costs of care, increased mortality and functional impairment. The pathomechanism of disease is poorly understood, with current diagnostic approaches somewhat subjective and arbitrary, and definitive diagnostic biomarkers are currently lacking. Despite the recent interest in delirium research, biomarker discovery for it remains new. Most attempts to discover biomarkers are targeted studies that seek to assess the involvement of one or more members of a focused panel of candidates in delirium. For a more unbiased, systems-biology view, we searched literature from MEDLINE, Cochrane Central, Web of Science, SCOPUS, and Dimensions between 2016 and 2021 for untargeted proteomic discovery studies for biomarkers of delirium conducted on human geriatric subjects. Two reviewers conducted independent review of all search results, and resolved discordance by concensus. From an overall search of 1172 publications, eight peer-reviewed studies met our defined inclusion criteria. The 370 unique peri-operative biomarkers identified in these reports are enriched in pathways involving the activation of the immune system, inflammatory response, and the coagulation cascade. IL-6 was the most commonly identified biomarker. By reviewing the distribution of protein biomarker candidates from these studies, we conclude that a panel of proteins, rather than a single biomarker, would allow for discriminating delirium cases from non-cases. The paucity of hypothesis-generating studies in the peer-reviewed literature also suggests that a systems-biology view of delirium pathomechanisms has yet to fully emerge.

show abstract

Salivary IL-6 Concentration Is Associated with Frailty Syndrome in Older Individuals

Cited by 9 publications

References 73 publications

Proteomics for the Discovery of Clinical Delirium Biomarkers: A Systematic Review of Major Studies

Proteomics for the Discovery of Clinical Delirium Biomarkers: A Systematic Review of Major Studies

Relationship between prevalence of cardiometabolic diseases, self-reported memory loss, and self-reported depressed mood of older adults in Korea according to frailty and physical activity status

Proteomics for the discovery of clinical delirium biomarkers: A systematic review of Major Studies

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