Salivary Glycopatterns as Potential Non-Invasive Biomarkers for Diagnosing and Reflecting Severity and Prognosis of Diabetic Nephropathy

Han, Qiuxia; Wang, Xiaochen; Ding, Xiaonan; Hao, Jing; Li, Qi; Wang, Jifeng; Yu, Hanjie; Tang, Zhen; Yang, Fuquan; Cai, Guangyan; Zhang, Dong; Zhu, Hanyu

doi:10.3389/fendo.2022.790586

Cited by 4 publications

(1 citation statement)

References 59 publications

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“…A recent study by Han et al (2022) screened different salivary glycopatterns in DN and NDRD patients using lectin microarrays, with validation conducted through lectin blotting. Diagnostic models were then constructed using logistic regression and artificial neural network analyses, and their validity was confirmed in another cohort [ 89 ].…”

Section: Salivary Markersmentioning

confidence: 99%

Liquid Biopsy: A Game Changer for Type 2 Diabetes

Gradisteanu Pircalabioru,

Musat,

Elian

et al. 2024

IJMS

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As the burden of type 2 diabetes (T2D) continues to escalate globally, there is a growing need for novel, less-invasive biomarkers capable of early diabetes detection and monitoring of disease progression. Liquid biopsy, recognized for its minimally invasive nature, is increasingly being applied beyond oncology, and nevertheless shows its potential when the collection of the tissue biopsy is not possible. This diagnostic approach involves utilizing liquid biopsy markers such as cell-free nucleic acids, extracellular vesicles, and diverse metabolites for the molecular diagnosis of T2D and its related complications. In this context, we thoroughly examine recent developments in T2D liquid biopsy research. Additionally, we discuss the primary challenges and future prospects of employing liquid biopsy in the management of T2D. Prognosis, diagnosis and monitoring of T2D through liquid biopsy could be a game-changing technique for personalized diabetes management.

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Section: Salivary Markersmentioning

confidence: 99%

Liquid Biopsy: A Game Changer for Type 2 Diabetes

Gradisteanu Pircalabioru,

Musat,

Elian

et al. 2024

IJMS

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Integrating machine learning and electrochemistry: A hybrid SA-DE-RF approach for optimizing electrode composition in water treatment

Tian,

Ma,

Geng

et al. 2024

Environmental Technology & Innovation

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Effects and Clinical Value of Peritoneal Dialysis on Water and Water Balance, Adverse Reactions, Quality of Life, and Clinical Prognosis in Patients with Decompensated Chronic Nephropathy: A Systematic Review and Meta-Analysis

Wang

Zhang

Sun

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To systematically evaluate the effects of peritoneal dialysis and hemodialysis on renal function and quality of life in patients with end-stage renal disease. An evidence-based medical rationale would be provided for peritoneal dialysis or hemodialysis treatment in patients with end-stage renal disease. Methods. The PubMed, EMBASE, ScienceDirect, Cochrane Library, China National Knowledge Infrastructure (CNKI), China VIP Database, Wanfang, and China Biomedical Literature Database (CBM) online databases were searched. Comparisons on the effects of peritoneal dialysis on renal function and quality of life were taken between patients with end-stage renal disease (RD). The data were extracted independently by two researchers. The bias-risk-included literatures were assessed according to the Cochrane manual 5.1.0 standard. RevMan 5.4 statistical software was used to analyze the collected data via meta-analysis. Results. Seven RCT articles were finally included. A total of 745 samples were analyzed via meta-analysis. The obvious heterogeneities of serum creatinine (Scr) and blood urea nitrogen (BUN) were discovered ( P < 0.00001 ) in the selective investigations. According to the results of this analysis, it was indicated that the renal function of patients with end-stage renal disease treated by peritoneal dialysis was significantly better than that of hemodialysis. According to the meta-analysis, there was obvious heterogeneity of life quality among the included research data. It was indicated that the score of quality of life of patients with end-stage renal disease treated by peritoneal dialysis was significantly better than that of hemodialysis. Conclusion. Compared with hemodialysis in the treatment of end-stage renal disease, the renal function and quality of life of patients with peritoneal dialysis are better than those of hemodialysis. More further studies and follow-up with higher methodological quality and longer intervention time are still needed for further verification.

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Salivary Glycopatterns as Potential Non-Invasive Biomarkers for Diagnosing and Reflecting Severity and Prognosis of Diabetic Nephropathy

Cited by 4 publications

References 59 publications

Liquid Biopsy: A Game Changer for Type 2 Diabetes

Liquid Biopsy: A Game Changer for Type 2 Diabetes

Integrating machine learning and electrochemistry: A hybrid SA-DE-RF approach for optimizing electrode composition in water treatment

Effects and Clinical Value of Peritoneal Dialysis on Water and Water Balance, Adverse Reactions, Quality of Life, and Clinical Prognosis in Patients with Decompensated Chronic Nephropathy: A Systematic Review and Meta-Analysis

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