Salivary Glands in Long‐term Alloxan‐diabetic Rats. A Quantitative Light and Electron‐microscopic Study

Abstract

glands in long-term alloxan-diabetic rats.A quantitative light and electron-microscopic study. Acta path. microbiol. immunol. scand. Sect. A, 95: 131-136, 1987.FiRy untreated diabetic animals were compared with 58 age-matched non-diabetic controls. Reduced salivary gland weight was evident after one month's diabetes and this was unchanged after 12 months of diabetes. Submandibular/sublingual gland weight was proportional to the reduced body weight in the diabetic rats. Parotid gland weight, however, was proportionally more reduced. Only diabetic rats had lipid inclusions in the acinar cells of their submandibular glands and the morphometrically estimated amount of inclusions was positively correlated to the blood glucose level. Acinar cell size was significantly increased in long-term diabetic rats as compared with short-term diabetic rats and controls. Capillary basement membrane width was significantly increased in long-term diabetic rats compared with age-matched controls and with short-term diabetic rats. Thus, both the degree and duration of diabetes have a major effect on salivary gland morphology in alloxan diabetic rats.

Morphometric Study of Diabetes Related Alterations in Human Parotid Gland and Comparison with Submandibular Gland

“…From a morphological point of view, severe alterations in human salivary glands were described as effects of diabetes, but nearly all reports concerned cases of evident sialosis (Donath and Seifert, 1975;Islas Andrade et al, 1992;Satoh and Yoshihara, 2004;Merlo et al, 2010). Many morphological alterations in salivary glands were also described in rodents (Cutler et al, 1979;Hand and Weiss 1984;Reuterving et al, 1987;Anderson et al, 1990;Szczepanski et al, 1998), in which the effects of this disease were found to be attenuated but not abolished by insulin treatment (Chan et al, 1993;Caldeira et al, 2005). However, given the diversity between human and rodent salivary glands, and given the multiplicity of diabetogenic substances, we believe that these data must be considered with caution when evaluating human data.…”

Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits

“…Hence, it is possible that reduction in amount of acinar tissue or acinar cell size may contribute to the decreased carbachol secretion we observed, although we did not examine it, representing a limitation of the study. However, it is noteworthy that electron microscopic study of rat parotid gland revealed that DM‐induced acinar abnormalities were associated with long‐term (12 months) and far less with short‐term (1 month) diabetic rats (Reuterving et al , ).…”

Electrochemical Behavior of Zanamivir at Gold-Modified Boron-Doped Diamond Electrodes for an Application in Neuraminidase Sensing

“…The CVs (Fig. 4) shows that the presence of 10 ¹2 M glucose in 0.1 M PBS (pH 7), equal to its concentration in normal blood, 32 caused the peak current of gold reduction decrease approximately 3.5%. On the other hand, the decrease of peak current caused by 10 ¹4 M Zanamivir was 15.3%.…”