Salivary gland pleomorphic adenoma in the Netherlands: A nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence

Valstar, Matthijs H.; Ridder, Mischa de; Broek, Esther C. van den; Stuiver, M.M.; Dijk, Boukje A. C. van; Velthuysen, Marie‐Louise F. van; Balm, A.J.M.; Smeele, Ludi E.

doi:10.1016/j.oraloncology.2017.01.004

Cited by 104 publications

(147 citation statements)

References 33 publications

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“…SGN are an uncommon heterogeneous group of lesions, with varying biological features, arising within tissue of the major or minor salivary glands (El‐Naggar, Chan, Grandis, Takata, & Slootweg, ). There is a dearth of information on the total incidence of SGN in various regions due to underreporting of cases in national cancer registries (Valstar et al, ).…”

Section: Introductionmentioning

confidence: 99%

Descriptive epidemiology of salivary gland neoplasms in Nigeria: An AOPRC multicenter tertiary hospital study

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Descriptive epidemiology of salivary gland neoplasms in Nigeria: An AOPRC multicenter tertiary hospital study

et al. 2018

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“…Data regarding the malignant transformation potential of a pleomorphic adenoma ranged from 1.1% to 6.2% . The progression of pleomorphic adenoma to CXPA involves a diversified process comprising genomic instability and successive mutations during the neoplastic process development, especially the particular loss of tumour suppressor genes, as well as the presence of epigenetic alterations .…”

Section: Discussionmentioning

confidence: 99%

Extracapsular invasion: A potential prognostic marker for Carcinoma ex‐pleomorphic adenoma of the salivary glands? A Systematic Review

Morais

Pinheiro

Sena

et al. 2019

J Oral Pathology Medicine

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Background The aim of the present study was to integrate available data published in the literature on extracapsular invasion in cases of CXPA that correlated findings with the prognosis of analysed patients. Methods An electronic search was carried out at the MEDLINE/PubMed, EMBASE and Cochrane Collaboration Library databases. Articles that assessed the relationship between extracapsular invasion and survival of patients diagnosed with CXPA were selected for the systematic review. Quality assessment was performed, in duplicate, for each eligible study by independent reviewers who used the operationalized prognostic biomarker reporting the REMARK guidelines. Results Eight published articles met all the inclusion criteria and were selected. Extracapsular invasion was evaluated in all selected studies and was correlated with clinical and pathological parameters. Recurrence and death due to the neoplastic process became a frequent finding in cases of tumours with extracapsular invasion >1.5 mm, being an important cut‐off point in the prognostic analysis of cases diagnosed as CXPA. Conclusions This systematic review demonstrates the importance of evaluating extracapsular invasion in cases diagnosed as CXPA, considering that tumours with invasion >1.5 mm, regardless of histopathological subtype, are associated with a worse prognosis. It is important to analyse the extracapsular invasion, especially as an auxiliary method to assess the prognosis of cases diagnosed in the initial clinical stages, thus identifying the possible biological behaviour of the neoplastic process and guiding the most appropriate patient management.

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“…The standard treatment for PA of the parotid gland is resection of the tumour with the surrounding salivary gland tissue and preservation of the facial nerve. PA recurrence is diagnosed in approximately 3% of patients [11]. The method of PA extracapsular enucleation is not widely accepted due to the significantly higher relapse rate of 45% [12].…”

Section: Discussionmentioning

confidence: 99%

“…The use of postoperative radiotherapy in the case of recurrent PA is controversial. According to some authors it prevents further recurrences, while according to others it creates the possibility of malignant transformation [1, 11,12].…”

Section: Discussionmentioning

confidence: 99%

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Malignant transformation of the salivary gland pleomorphic adenoma in myoepithelial carcinoma – the report of two cases

Szabelska¹,

Rzepakowska

Szczepankiewicz

et al. 2019

Pol Otorhino Rev

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A multiform adenoma is the most commonly diagnosed benign tumor of the salivary glands. In the majority of patients, surgical resection of the tumor with the adequate surrounding tissue of salivary gland allows for complete recovery. A small percentage of the cases is a recurring pleomorphic adenoma. Even more rarely the diagnosis of carcinoma ex pleomorphic adenoma is made. The study presents two clinical cases of the malignant transformation of pleomorphic adenoma into the myoepithelial carcinoma. The surgical treatment and additional radiotherapy were performed in both cases.

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Salivary gland pleomorphic adenoma in the Netherlands: A nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence

Abstract: This first nationwide study clearly showed sex differences in SGPA epidemiology, possibly suggesting some underlying hormonal mechanism. Long-term recurrence risks were low, and secondary malignant transformation risks were very low.

Cited by 104 publications

References 33 publications

Descriptive epidemiology of salivary gland neoplasms in Nigeria: An AOPRC multicenter tertiary hospital study

Descriptive epidemiology of salivary gland neoplasms in Nigeria: An AOPRC multicenter tertiary hospital study

Extracapsular invasion: A potential prognostic marker for Carcinoma ex‐pleomorphic adenoma of the salivary glands? A Systematic Review

Malignant transformation of the salivary gland pleomorphic adenoma in myoepithelial carcinoma – the report of two cases

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