Salivary gland myoepithelial carcinoma

Vilar-González, Santiago; Bradley, Katherine; Rico-Pérez, José M.; Gołka, Dariusz; Nigam, A.; Sivaramalingam, M.; Kazmi, Syed Mohammad Ali

doi:10.1007/s12094-015-1329-4

Cited by 21 publications

(44 citation statements)

References 46 publications

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“…Precise preoperative diagnosis of MEC ex PA is almost impossible, and risk factors for prognosis remain uncertain [2]. Symptoms of MEC are similar to those of other salivary gland tumors, i.e., a mass with or without pain, facial palsy, and fixation of the mass to the underlying structures [3].…”

Section: Discussionmentioning

confidence: 99%

“…Myoepithelial carcinoma (MEC) is a rare salivary gland tumor, accounting for 0.1–0.45 % of all salivary gland tumors [1, 2]. MEC generally arises from the parotid gland (29–82 % of all cases) [2] and rarely from the submandibular gland, minor salivary glands, or the upper respiratory tract [2–4].…”

Section: Introductionmentioning

confidence: 99%

“…MEC generally arises from the parotid gland (29–82 % of all cases) [2] and rarely from the submandibular gland, minor salivary glands, or the upper respiratory tract [2–4]. Other than the head and neck, MEC has been reported in the lung, breast, bronchus, mediastinum, and others sites [2, 5, 6]. Because of its rarity, the clinical features and pathophysiology of MEC are not well characterized; most articles describing MEC are case reports.…”

Section: Introductionmentioning

confidence: 99%

“…Because of its rarity, the clinical features and pathophysiology of MEC are not well characterized; most articles describing MEC are case reports. According to a few large case series (>10 cases), the mortality rate of MEC is 20–73 % [2, 7–9]. Regional node involvement is reported in 0–41 % of cases [3, 7].…”

Section: Introductionmentioning

confidence: 99%

“…Regional node involvement is reported in 0–41 % of cases [3, 7]. A distant metastasis rate is approximately 6.8–47 %, most commonly to the lung, brain, spine, and skin [2]. These values may differ considerably depending on the site of origin of MEC.…”

Section: Introductionmentioning

confidence: 99%

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Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports

et al. 2016

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BackgroundMyoepithelial carcinoma (MEC) is a rare salivary gland tumor. Its long-term prognosis remains unknown because of the paucity of reported cases with long-term follow-up. Although some case series exist, the clinical features of MEC vary considerably depending on the site of origin. Therefore, accumulation of these rare cases is important.Case presentationCase 1: An 89-year-old man presented with a 10-year history of a mass originating from the right parotid gland and involving the neck. The mass grew rapidly for 3 months, reaching approximately 8 cm. There was no facial paralysis. MEC ex pleomorphic adenoma (PA) was suspected. Superficial parotid gland resection was performed in 2013; the tumor grade was pT3N0M0, and the resection margins were free of carcinoma. Because of several high-risk factors for metastasis (i.e., invasive carcinoma ex PA, high MIB1 index, and mutant p53 protein positivity), radiotherapy and chemotherapy were recommended as adjuvant therapy. Although the patient refused adjuvant therapy, he was recurrence-free at 36 months after surgery.Case 2: A 54-year-old woman presented with a >10-year history of a right submandibular mass, which grew rapidly for 1 year, reaching approximately 6 cm. Preoperative diagnosis was PA of the right submandibular gland. Submandibular gland resection was performed in 2013. Pathological analysis revealed invasive MEC ex PA, pT3N0M0; in addition, the carcinoma portion had an extra capsule and had invaded the platysma muscle close to the margin. An MIB1 index of 40 % and mutant p53 protein positivity indicated a high risk for metastasis. Additional resection and right neck dissection revealed no residual carcinoma. The patient refused adjuvant chemotherapy. One year after surgery, metastasis to the right pulmonary hilar node and both lungs were detected. Chemotherapy prevented recurrent growth of the lesion and extended survival. The patient was alive with cancer 30 months after the first surgery.ConclusionsHigh expression of the Ki67 labeling index might reflect prognosis of these cases. Chemotherapy for distant metastasis was effective, as expected. Further accumulation of cases and long follow-up data are needed to elucidate the pathophysiology and prognosis of MEC ex PA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports

et al. 2016

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The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Lubin

Song

Zafar

et al. 2019

Diagnostic Cytopathology

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Oncocytic and oncocytoid lesions represent a distinct subset of salivary gland lesions. True oncocytic lesions of the salivary gland are entirely composed of oncocytes. These are characterized by the presence of abundant eosinophilic granules due to the presence of abundant cytoplasmic mitochondria. Oncocytic lesions of the salivary gland include oncocytosis, oncocytoma, and oncocytic carcinoma. In addition to the true oncocytic lesion, there exists another group of salivary gland lesions, which demonstrate cells with abundant and occasionally granular cytoplasm. These are often termed as “oncocytoid” lesions. The recently proposed Milan System for reporting salivary gland cytology clearly states that fine‐needle aspiration specimens representing oncocytic/oncocytoid lesions of salivary gland cannot effectively distinguish between a nonneoplastic lesion, benign and malignant neoplasms. Therefore, most lesions lacking classic cytomorphologic features will be classified under the umbrella diagnostic term of “Salivary Gland Neoplasm of Uncertain Malignant Potential” (SUMP). In this review, we discuss and illustrate key clinicopathologic and radiologic features that can help the practicing cytopathologist narrow down the differential and provide the best management based diagnosis.

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Prognostic analysis and establishment of a nomogram in patients with myoepithelial carcinoma of the salivary gland: A population‐based study

Liu

Mao

Zhang

et al. 2022

Laryngoscope Investig Oto

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Background: Currently, the clinicopathological characteristics and prognosis of myoepithelial carcinoma of salivary gland (MC-SG) have not been defined well. The present study aimed to describe the clinicopathological characteristics and prognosis of MC-SG patients. Methods:The Surveillance, Epidemiology, and End Results database was searched for all patients diagnosed with MC-SG between 1991 and 2016. The Kaplan-Meier method and log-rank tests were used to evaluate the survival. Univariate and multivariate Cox regression analysis were used to identify prognostic biomarkers for overall survival (OS) and disease-specific survival (DSS). Furthermore, a prognostic nomogram was established, and its predictive accuracy and discriminative ability were determined using the concordance index (C-index).Results: In total, 245 patients diagnosed with MC-SG were identified. The median OS was 152.0 months, with 3-, 5-, and 10-year survival rates of 79.8%, 69.2%, and 50.3%. The 3-, 5-, and 10-year DSS rates were 82.5%, 77.1%, and 61.9%, respectively.Regarding the treatment regimen, most patients (92.2%) underwent surgery, and 103 patients (42.4%) received postoperative radiotherapy. Surgery could significantly prolong OS and DSS (p < .05), but postoperative radiotherapy did not significantly prolong OS and DSS when compared with individuals receiving surgery alone (p > .05). Multivariate Cox analysis revealed that T category (T4), lymph node metastasis (N2), distant metastasis (M1), and poor differentiation were independent unfavorable prognostic factors for OS and DSS. Older age (>62 years) was also independently associated with OS. In addition, the C-index for the established OS-and DSS-specific nomogram was 0.80 (95% CI: 0.72-0.88) and 0.82 (95% CI: 0.73-0.90). Conclusion:Age, tumor invasion, metastases, and pathological grade were independently associated with prognosis of MC-SG patients, and the prognostic nomogram of this rare disease was established.

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Salivary gland myoepithelial carcinoma

Cited by 21 publications

References 46 publications

Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports

Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports

The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Prognostic analysis and establishment of a nomogram in patients with myoepithelial carcinoma of the salivary gland: A population‐based study

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