Salivary Gland Malignancies

Carlson, Eric R.; Schlieve, Thomas

doi:10.1016/j.coms.2018.08.007

Cited by 75 publications

(64 citation statements)

References 60 publications

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“…The respective LR + and LR-values of 3.7 and 0.15 indicate that DWI can rule out malignancy but is less able to confirm the presence of malignant disease [35,36]. This characteristic could facilitate surgical decisions, which would reduce the risk of facial nerve damage and preserve the parotid gland function [2].…”

Section: Discussionmentioning

confidence: 99%

“…Although parotid tumors are rare, accounting for approximately 3% of all head and neck tumors, the incidence of this entity is increasing annually [1]. According to the World Health Organization [2], up to 25 % of all parotid tumors are malignant and can be classified into 20 subtypes. Clinically, malignances must be differentiated accurately from benign lesions, as the two tumor types require very different treatment approaches [2].…”

Section: Introductionmentioning

confidence: 99%

“…According to the World Health Organization [2], up to 25 % of all parotid tumors are malignant and can be classified into 20 subtypes. Clinically, malignances must be differentiated accurately from benign lesions, as the two tumor types require very different treatment approaches [2].…”

Section: Introductionmentioning

confidence: 99%

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Performance of diffusion-weighted imaging for the diagnosis of parotid gland malignancies: A meta-analysis

Chen

Liu

Tang

et al. 2021

European Journal of Radiology

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This study aimed to assess the diagnostic performance of diffusion-weighted imaging (DWI) for parotid gland malignancies. Methods: Four databases (PubMed, the Cochrane Library, Embase, and Web of Science) were searched systematically and retrospectively by two researchers until May 18, 2020. The methodological quality of the studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. A bivariate random effects model was used to pool the sensitivity and specificity data for the apparent diffusion coefficient (ADC). Summary receiver operating characteristic curve was constructed, and the area under the curve (AUC) was calculated. The positive (LR+) and negative likelihood ratios (LR-) were also calculated. Subgroup and meta-regression analyses were performed to evaluate heterogeneity within studies. Results: Sixteen studies involving 1004 patients were included. The pooled sensitivity, specificity, and AUC for the ADC to distinguish malignant from begin parotid lesions were 89 %, 76 %, and 0.91, respectively. The LR + was 3.7 and LR-was 0.15, respectively. Subgroup analyses revealed that the applied cut-off b values and study size were sources of heterogeneity for the ADC. There were publication bias concerns. Conclusions: Our meta-analysis suggests that the ADC value provides excellent sensitivity and moderate specificity for the diagnosis of malignant lesions in the parotid gland. However, substantial heterogeneity was found. Therefore, additional larger, prospective studies in combination with standard techniques focusing on parotid tumors should be conducted to determine the true performance of DWI for the differential diagnosis of parotid lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Performance of diffusion-weighted imaging for the diagnosis of parotid gland malignancies: A meta-analysis

Chen

Liu

Tang

et al. 2021

European Journal of Radiology

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“…The standard approach has been total parotidectomy or lateral parotid lobectomy. One debated issue is whether to extirpate the deep lobe of the gland to remove the intraparotid deep lobe nodes [1][2][3][4][5][6][7][8][9][10]. This is done when there is evidence of superficial parotid or neck node metastasis from a parotid gland cancer, or if the tumor is of high-grade histology.…”

Section: Introductionmentioning

confidence: 99%

Is There A Role for Limited Parotid Resections for Primary Malignant Parotid Tumors?

et al. 2020

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(1) Background: Lateral or total parotidectomy are the standard surgical treatments for malignant parotid tumors. However, some authors have proposed a more limited procedure. (2) Methods: We performed a review of the literature on this topic. Studies were included that met the following criteria: malignant parotid tumors, information about the extent of surgical resection, treated with less than a complete lateral lobectomy, and information on local control and/or survival. Nine articles fulfilled the inclusion criteria. (3) Results: Eight of the nine series reported favorable results for the more limited approaches. Most used them for small, mobile, low-grade cancers in the lateral parotid lobe. Most authors have used a limited partial lateral lobectomy for a presumed benign lesion. The remaining study analyzed pediatric patients treated with enucleation with poor local control. (4) Conclusions: There is weak evidence for recommending less extensive procedures than a lateral parotid lobectomy. In the unique case of a partial lateral parotidectomy performed for a tumor initially thought to be benign but pathologically proved to be malignant, close follow-up can be recommended for low grade T1 that has been excised with free margins and does not have adverse prognostic factors.

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“…Molecular genetic findings and immunohistochemistry have been integrated into the tumors profiles in order to obtain homogenous and reproducible diagnostic criteria. Nevertheless, the extreme clinical and morphological variability, does not always lead to conclusions that fully fit into the WHO parameters [2,3].…”

Section: Introductionmentioning

confidence: 99%

Unusual Salivary Gland Tumor of the Palate: Clinical, Histological and Immunohistochemical Features

Petruzzi

Vella

Sportelli

et al. 2019

The XV National and III International Congress of the Italian Society of Oral Pathology and Medicine

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Salivary Gland Malignancies

Cited by 75 publications

References 60 publications

Performance of diffusion-weighted imaging for the diagnosis of parotid gland malignancies: A meta-analysis

Performance of diffusion-weighted imaging for the diagnosis of parotid gland malignancies: A meta-analysis

Is There A Role for Limited Parotid Resections for Primary Malignant Parotid Tumors?

Unusual Salivary Gland Tumor of the Palate: Clinical, Histological and Immunohistochemical Features

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