Salivary Gland–like Tumors of the Breast Express Basal-type Immunohistochemical Markers

Abstract

Adenoid cystic, mucoepidermoid, and polymorphous low-grade carcinomas of the breast express immunohistochemical markers that characterize the intrinsic basal-like subtype of breast cancer.

Acinic Cell Carcinoma of the Breast Arising in Microglandular Adenosis

“…This special histological subtype is usually negative for estrogen receptors, progesterone receptors, and HER2 (so called “triple negative” cancers) [3]; however, recently, some authors reported a positivity for both estrogen and progesterone receptors in a case of ACC [15], as observed in the present case in which we found immunoreactivity for progesterone receptors.…”

“…ACC of the breast is a very rare subtype of mammary carcinoma and it belongs to the group of salivary gland-like tumors of the breast: a broad histological spectrum of breast tumors similar to those more commonly occurring in the salivary glands [2]; they represent approximately 2% of primary breast carcinomas [3]. …”

“…This rare malignant tumour, first described in 1996 by Roncaroli et al [1], is essentially the breast counterpart of a similar tumour commonly found in the parotid gland and showing a diffuse infiltrative growth pattern with small acinar or glandular structures which are composed of monotonous proliferation of cells with a granular or clear cytoplasm, thus resembling acinar cells of the salivary glands [2, 3]. …”

Current Status and Progress of Breast Adenoid Cystic Carcinoma

“…The luminal cells are positive for CK7, CK8/18, epithelial membrane antigen, and CD117(c -kit) (Franzese et al, 2013). The myoepithelial-basal cells' marker includs CK5, CK5/6, CK14, CK17, and it also expresses partial myoepithelial cell markers such as p63, actin, calponin, S-100 protein, vimentin and epidermal growth factor receptor (EGFR) are often positive (Reyes et al, 2013). The glandular epithelial cells and myoepithelial-basal cells of Adenoid cystic carcinoma of the breast are most often hormone receptor [estrogen receptor (ER) and progesterone receptor (PR)] negative, do not express human epidermal growth factor receptor 2 (Her2) (Kulkarni et al, 2013).…”

MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas

“…Az emlő "nyálmirigy jellegű" tumorai az összes rosszindulatú emlődaganatnak csupán mintegy 2%-át teszik ki [1], mégis számos daganatféleséget sorolhatunk ebbe a csoportba. Ezek az elváltozások nemcsak morfológiailag, hanem klinikai lefolyásukat tekintve is eltérnek egymástól: míg a malignus myoepithelioma a csoport egyik rossz prognózisú képviselője, az emlő adenoid cysticus carcinomája (breast-derived adenoid cystic carcinoma -bACC) egy igen kedvező klinikai lefolyást mutató daganattípus.…”