Salivary gland involvement in rheumatoid arthritis and its relationship to induced oxidative stress

Nagler, Rafael M.; Salameh, Fares; Reznick, Abraham Z.; Лившиц, В. А.; Nahir, A. M.

doi:10.1093/rheumatology/keg362

Cited by 49 publications

(33 citation statements)

References 23 publications

(34 reference statements)

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“…The currently reported increase in various salivary antioxidant parameters is of no surprise; in recent years, oxidative stress has become increasingly recognized as one of the major factors contributing to the chronic inflammatory process both in RA and in JIA patients (9,11,(29)(30)(31)(32)(33). Furthermore, increased MMP expression and activity was reportedly induced by the greater oxidative stress in general and also in rheumatoid synovial cells, as was shown in numerous studies; and vice versa, MMP expression and activity was decreased by antioxidants such as vitamin E or SOD (18,(34)(35)(36)(37)(38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress also was shown to induce various inflammatory mediators of rheumatoid arthritis, such as prostaglandins formed by Cox-2 in the synovium (44). Such proinflammatory cytokines have been shown to induce MMPs and, therefore, it is not surprising that anti-TNF therapies have been found to reduce serum MMP levels in patients with RA (11)(12)(13)(14). Indeed, Mentzel et al, (45) who studied a rat model for antigen-induced arthritis, reported that TNF-α increased total MMP activity, levels of IL-6 and oxidant nitric oxide (NO) in the supernatants of synoviocytes, and induced the expression of MMP9 (as did IL-1β).…”

Section: Discussionmentioning

confidence: 99%

“…Also, Walton et al (10) previously reported salivary gland involvement in JIA, expressed by a decrease in both salivary flow rates. In yet another study, our group found that the antioxi-dant profile of saliva secreted by rheumatoid arthritis (RA) patients showed remarkably increased levels of antioxidant enzymes both in saliva and in serum, especially in severely affected patients, and also a decrease in salivary rate (11). Furthermore, involvement of the salivary glands in adults with RA has been recognized for quite some time.…”

Section: Introductionmentioning

confidence: 99%

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Salivary Antioxidants and Metalloproteinases in Juvenile Idiopathic Arthritis

Brik

Rosen

Savulescu

et al. 2009

Mol Med

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Juvenile idiopathic arthritis (JIA) is the most common autoimmune inflammatory disease in children; joint inflammation is the hallmark of the disease. Thirty-five children with JIA were studied, of whom 26 had active disease and 14 were receiving anti-TNF therapy (5 with Infliximab, 9 with Etanercept). Sixteen healthy controls also were studied. Saliva samples were obtained for analysis of anti-oxidant status, metalloproteinases (MMPs) and sialochemistry. The total antioxidant status was significantly higher in the saliva of all JIA patients, whether treated (P = 0.014) or not treated (P = 0.038) with anti-TNF agents. The increase in antioxidant status (TAS) in the saliva of the active patients was nearly two times higher than that of non-active patients (P = 0.01). MMP levels were significantly lower in JIA patients than in controls. MMP-9, MMP-3 and MMP-2 were lower in JIA patients without anti-TNF treatment by 36.7% (P = 0.01), 30.0% (P = 0.0001) and 10.7% (P = 0.0001), respectively. A greater reduction in MMP levels was observed in the group of patients treated with anti-TNF drugs: MMP-9, MMP-3 and MMP-2 were lower than in controls by 51.1% (P = 0.0001), 61.5% (P = 0.0001) and 55.4% (P = 0.0001), respectively. Children with JIA exhibited a significantly higher salivary antioxidant activity and significantly lower MMP levels. Anti-TNF treatment was associated with a further decrease in MMP levels in the saliva of JIA patients while an active state of JIA was associated with a further increase in the salivary antioxidant activity. Anti-TNF treatment may modulate the degradation process during the course of arthritis by inhibition of the activity of MMP .

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Salivary Antioxidants and Metalloproteinases in Juvenile Idiopathic Arthritis

Brik

Rosen

Savulescu

et al. 2009

Mol Med

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“…The biological mechanism of the impairment of salivary gland function has been studied, but a detailed understanding of it has not yet been achieved. However, it has been supposed that reactive oxygen species (ROS) are involved in the impairment of salivary gland function due to aging, inflammation, drugs, and ionizing irradiation [1][2][3][4]. Not only extracellular but also intracellular ROS regulate cellular biological activities by activation and also suppression of proteins as well as by modification of DNA [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…In addition to these ROS, there are a variety of oxidized reactive lipids, which are associated with damage of blood vessel walls, perfusion-induced damage of the brain, and apoptotic degeneration of liver and kidney cells [11][12][13][14]. Of the ROS, O 2 -is crucial in this damage because O 2 -leads to generation of OH .…”

Section: Introductionmentioning

confidence: 99%

Ionizing irradiation induces apoptotic damage of salivary gland acinar cells via NADPH oxidase 1-dependent superoxide generation

Tateishi

Sasabe

Ueta

et al. 2008

Biochemical and Biophysical Research Communications

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Salivary uric acid and C‐reactive protein associations with hypertension in Midwestern Latino preadolescents and their parents

Jones

Elwazeer

Taylor

2017

Developmental Psychobiology

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Latino families face increased risk for hypertension. Serum-based uric acid and Creactive protein have been linked to hypertension. However, a paucity of salivary biomarker data exists in this area for Latino families. Using salivary biomarkers enables less invasive options for biomedical and biosocial research, which is especially important among vulnerable populations facing increased health disparities. This study examined the associations between salivary uric (sUA) acid, salivary C-reactive protein (sCRP), and hypertension among 151 participants (57 children, 57 mothers, 37 fathers) from 57 Midwestern Latino families. Participants self-administered the salivary samples, and blood pressure was measured by researchers. Results showed sUA was associated across family members, and child hypertension was related to parents′ hypertension. sCRP was only related to sUA in fathers. Findings highlight the familylevel health connections, along with the importance for further investigations using salivary biomarkers with Latinos, and the need for a robust sUA cut-off for hyperuricemia. K E Y W O R D Shealth, hypertension, Latinos, salivary C-reactive protein (sCRP), salivary uric acid (sUA)

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Salivary gland involvement in rheumatoid arthritis and its relationship to induced oxidative stress

Cited by 49 publications

References 23 publications

Salivary Antioxidants and Metalloproteinases in Juvenile Idiopathic Arthritis

Salivary Antioxidants and Metalloproteinases in Juvenile Idiopathic Arthritis

Ionizing irradiation induces apoptotic damage of salivary gland acinar cells via NADPH oxidase 1-dependent superoxide generation

Salivary uric acid and C‐reactive protein associations with hypertension in Midwestern Latino preadolescents and their parents

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