Salivary gland fine-needle aspiration biopsy: quality assurance results from a tertiary cancer center

Ratzon, Fanni; Feliciano, Dominique L; Katabi, Nora; Xu, Bin; Lin, Oscar; Wei, Xiaorong

doi:10.1016/j.jasc.2023.01.001

Cited by 3 publications

(6 citation statements)

References 34 publications

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“…Fortunately, distribution of these two categories are relatively lower than the other categories. In our series, AUS and SUMP comprised 3.6% and 7.8% of the aspirates, respectively, which is consistent with the reports (2.8%–11.5% for AUS, 5.9%–21.5% for SUMP) 24,26–34 . Comparing the category distribution between the two cancer centers in our series, we found that the SUMC series had higher AUS and lower SUMP distributions than JXCH did.…”

Section: Discussionsupporting

confidence: 92%

“…In our series, AUS and SUMP comprised 3.6% and 7.8% of the aspirates, respectively, which is consistent with the reports (2.8%-11.5% for AUS, 5.9%-21.5% for SUMP). 24,[26][27][28][29][30][31][32][33][34] Comparing the category distribution between the two cancer centers in our series, we found that the SUMC series had higher AUS and lower SUMP distributions than JXCH did. Diagnostic efficacy of FNAC for salivary gland lesions is calculated based on determinate categories including NN, BN, SM, and M. As listed in Table 6, the ranges of ROM in NN, BN, SM, and M are 4.4%-22.0%, 2.2%-25.0%, 66.7%-100%, and 91.3%-100%, respectively, which fall in the implied ROM by MSRSGC panel.…”

Section: Discussionmentioning

confidence: 55%

“…3 A wide range of ROM has been reported regarding AUS (17.0%-37.5%) and SUMP (24.6%-62.0%). 24,[26][27][28][29][30][31][32][33][34] It is recommended that AUS cases should undergo repeat FNAC or surgery, and surgery should be considered for patients with SUMP category because of their high ROM. Fortunately, distribution of these two categories are relatively lower than the other categories.…”

Section: Discussionmentioning

confidence: 99%

“…Except the higher proportion of metastatic carcinoma due to the aforementioned reasons, the prevalence of the salivary pathologies in our series is similar to the literatures. 24,[26][27][28][29][30][31][32][33][34]37 T A B L E 5 The performance of the Milan system for reporting salivary gland cytopathology for detecting malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…A majority of these cases will include cellular benign neoplasms, neoplasms with monomorphic lesional cells, basaloid neoplasms, oncocytic neoplasms, neoplasms with clear cell features, neoplasms with atypical features, and low‐grade carcinomas 3 . A wide range of ROM has been reported regarding AUS (17.0%–37.5%) and SUMP (24.6%–62.0%) 24,26–34 . It is recommended that AUS cases should undergo repeat FNAC or surgery, and surgery should be considered for patients with SUMP category because of their high ROM.…”

Section: Discussionmentioning

confidence: 99%

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Rapid on‐site evaluation improves diagnostic performance of fine‐needle aspiration cytology for salivary lesions: Comparison of data from two cancer centers in southern China

Xu,

Deng,

Peng

et al. 2024

Diagnostic Cytopathology

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ObjectivesTo evaluate the diagnostic performance of Milan system for reporting salivary gland cytopathology (MSRSGC) in two southern China tertiary cancer centers and investigate the impact of rapid on‐site evaluation (ROSE) on FNAC performance.Materials and MethodsFive hundred and forty‐nine patients who underwent FNAC for salivary lesions with surgical follow‐up from two centers were enrolled in this retrospective cohort study. All slides were recategorized using MSRSGC after consensus on diagnostic criteria for each category. The diagnostic performance of FNAC for salivary lesions was evaluated and compared and the impact of ROSE on FNAC performance was analyzed.ResultsThe distribution of cases per category based on the MSRSGC criteria in the whole series was as followed: ND 49 (8.9%), NN 76 (14.4%), BN 262 (47.7%), AUS 20 (3.6%), SUMP 43 (7.8%), SM 21 (3.8%), M 78 (14.2%). The SUMC series had significantly more ND distributions than JXCH did (16.2% vs. 0, p = .000). Risk of malignancy for each category in the total series was as followed: 42.9% for ND, 9.2% for NN, 3.8% for BN, 30.0% for AUS, 23.3% for SUMP, 81.0% for SM, and 94.9% for M. When ND and AUS/SUMP were excluded, the sensitivity, specificity, PPV, NPV, and accuracy were 84.0%, 97.1%, 89.9%, 95.1%, and 94.0%, respectively; sensitivity, specificity, PPV, NPV, and accuracy were comparable between the two centers.ConclusionsFNAC using MSRSGC provides a good tool in preoperative evaluation for salivary lesions in southern China. ROSE improves its diagnostic performance by reducing the ratio of the ND category.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Rapid on‐site evaluation improves diagnostic performance of fine‐needle aspiration cytology for salivary lesions: Comparison of data from two cancer centers in southern China

Xu,

Deng,

Peng

et al. 2024

Diagnostic Cytopathology

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A Retrospective Cytomorphologic Analysis of Salivary Gland Fine Needle Aspirates Classified as Salivary Gland Neoplasm of Uncertain Malignant Potential: A 6‐year Institutional Experience

Agarwal

2024

Diagnostic Cytopathology

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BackgroundThe Milan System for Reporting Salivary Gland Cytopathology is an effective reporting system for salivary gland fine needle aspirations with well‐established risks of malignancy. Salivary gland neoplasm of uncertain malignant potential (SUMP) comprises a heterogenous group of lesions which have features that can be recognized as at least neoplastic but preclude further classification into benign or malignant. In this study, we reviewed the cytomorphologic features of salivary gland fine needle aspirations diagnosed as SUMP at our institution (over the past 6 years) and correlated those with the final diagnosis on surgical follow up.DesignA retrospective search was performed to identify cases classified as SUMP at our institution from January 2018 to February 2024. Cytology slides were reviewed, and cases were subclassified based on key cytomorphologic features into the following categories: (1) basaloid, (2) oncocytic, (3) with clear cell features and (4) mixed features (myoepithelial/oncocytoid/squamoid features). Histologic diagnosis was recorded if available.ResultsA total of 36 cases of SUMP were identified; 31/36 had surgical follow up; final diagnosis included 22 benign lesions (2 non‐neoplastic and 20 benign neoplasms), and nine malignant lesions. The overall risk of neoplasm and risk of malignancy were 93.5% and 29% respectively, with the oncocytic sub‐category recording the highest ROM (42.8%). Mucoepidermoid carcinoma was the most common malignant diagnosis and pleomorphic adenoma the most common benign diagnoses.ConclusionsOur study supports the subclassification of SUMP lesions based on key cytomorphologic features, thereby aiding in refining this ambiguous entity and providing a precise risk assessment.

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The Milan System for Reporting Salivary Gland Cytopathology: the experience of a tertiary cancer center with emphasis on non-mucinous cysts and improving diagnostic results

Gomez,

Yu,

Sneige

2024

Journal of the American Society of Cytopathology

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Salivary gland fine-needle aspiration biopsy: quality assurance results from a tertiary cancer center

Cited by 3 publications

References 34 publications

Rapid on‐site evaluation improves diagnostic performance of fine‐needle aspiration cytology for salivary lesions: Comparison of data from two cancer centers in southern China

Rapid on‐site evaluation improves diagnostic performance of fine‐needle aspiration cytology for salivary lesions: Comparison of data from two cancer centers in southern China

A Retrospective Cytomorphologic Analysis of Salivary Gland Fine Needle Aspirates Classified as Salivary Gland Neoplasm of Uncertain Malignant Potential: A 6‐year Institutional Experience

The Milan System for Reporting Salivary Gland Cytopathology: the experience of a tertiary cancer center with emphasis on non-mucinous cysts and improving diagnostic results

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