Salivary Gland Disorders and Diseases

Jensen, Siri Beier; Vissink, Arjan; Firth, Norman

doi:10.1007/978-3-319-28100-1_19-1

Cited by 2 publications

(10 citation statements)

References 194 publications

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Section: Salivary Gland Dysfunction Xerostomia and Sialorrheamentioning

confidence: 99%

“…A number of immune‐mediated or autoimmune conditions may affect salivary glands, such as Sjögren syndrome, lupus erythematosus, sarcoidosis, and IgG4‐related sialadenitis 5 . Sjögren syndrome is an autoimmune disease resulting in xerostomia and xerophthalmia (dry eyes) 5,28 . Sjögren syndrome is prevalent in 0.05% of the general population and is characterized by lymphocytic destruction and lymphoepithelial lesions of exocrine glands 29,30 .…”

Section: Salivary Gland Dysfunction Xerostomia and Sialorrheamentioning

confidence: 99%

“…Juvenile recurrent parotitis is a self‐limiting condition affecting children resulting in recurrent parotid swelling and salivary hypofunction with or without pain but with an absence of suppuration 37 . Although less prevalent since the introduction of the MMR vaccine, mumps (epidemic parotitis) is caused by Paramyxoviridae and may cause obstruction of the ductal system secondary to glandular enlargement consequently hindering salivary secretion 5 . Other viruses that can affect the salivary glands and cause dysfunction include coxsackie viruses, SARS‐CoV‐2, Epstein‐Barr virus, cytomegalovirus, and HIV 38,39 …”

Section: Salivary Gland Dysfunction Xerostomia and Sialorrheamentioning

confidence: 99%

“…Sialometry is a measurement of pooled unstimulated or stimulated salivary flow or salivary flow from specific minor or major salivary glands 12 . This is done after standardizing basal salivary flow as patients are instructed not to drink, eat, or smoke for ∼60 min prior to measuring salivary flow 5 …”

Section: Diagnosis and Management Of Salivary Gland Dysfunctionmentioning

confidence: 99%

“…Acinar cells, which contribute the most proteins and peptides to the final saliva, secrete isotonic (i.e., plasma) saliva into a duct system that channels from the gland to the ductal opening into the oral cavity. Within the salivary gland ducts, acinar products undergo optimization and modification of content as they first pass through intercalated ducts where ductal cells secrete minor portions of proteins (e.g., lysozyme, lactoferrin), then through the striated ducts where ductal cells mediate electrolyte exchange, secretion, and reabsorption (e.g., Na + , Cl − , HCO 3 − , K + ) modifying saliva from isotonic to hypotonic 5 . As saliva reaches the excretory ducts, the electrolyte content is continuously modified until the final saliva enters the oral cavity.…”

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confidence: 99%

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Prosthodontic implications of saliva and salivary gland dysfunction

Khoury

Sultan

2023

Journal of Prosthodontics

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PurposeTo provide a detailed overview of the fundamentals of saliva constituents and production. The review outlines the clinical manifestations as a consequence of salivary gland dysfunction and management strategies for patients with salivary gland dysfunction. Prosthodontic implications of saliva and salivary gland dysfunction are presented.Materials and methodsEnglish‐language literature relating to saliva constituents, physiologic saliva production, clinical manifestations secondary to salivary gland dysfunction, salivary biomarkers, and management strategies were retrieved via electronic search. Relevant articles were summarized for this manuscript with a view toward providing pragmatic information.ResultsSaliva is produced by three pairs of major and minor salivary glands. The major salivary glands, namely, the parotid, submandibular, and sublingual glands, contribute approximately 90% of saliva production. Saliva contains serous and mucinous secretions produced by different types of cells within salivary glands. Parasympathetic and sympathetic fibers innervate the major salivary glands, and upon stimulation, the parasympathetic innervation increases serous secretions, while the sympathetic innervation increases protein secretion. Stimulated saliva is mainly derived from the parotid glands which are composed of serous acini, while unstimulated saliva is mainly derived from the submandibular glands which are composed of mixed seromucous acini. As major salivary glands contribute the most to salivary flow, local or systemic factors influencing those glands can disrupt saliva production resulting in clinically significant oral manifestations.ConclusionThis review provides a fundamental overview of saliva production. In addition, the review highlights the various clinical manifestations secondary to salivary gland dysfunction, explores salivary biomarkers for screening of systemic diseases, discusses management strategies for patients with salivary gland dysfunction, and outlines the prosthodontic implications of saliva and salivary gland dysfunction.

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Section: Salivary Gland Dysfunction Xerostomia and Sialorrheamentioning

confidence: 99%