Salivary gland carcinomas of the larynx: A national study in Denmark

Nielsen, Troels Krogh; Bjørndal, Kristine; Krogdahl, Annelise; Primdahl, Hanne; Kristensen, Claus Andrup; Andersen, Elo; Godballe, Christian

doi:10.1016/j.anl.2012.02.003

Cited by 30 publications

(40 citation statements)

References 14 publications

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“…The late diagnosis of non-glottic tumours with the known predilection of submucosal, perineural and perivascular spreading might account for the locally advanced tumours and the high incidence of positive/insufficient margins on surgical specimens [7]. In our series, 5 patients (33%) had T3 and 7 patients (47%) had T4 disease, which are higher rates than those reported elsewhere [1,8].…”

Section: Discussionmentioning

confidence: 67%

Malignant Minor Salivary Gland Carcinomas of the Larynx

Zhang¹,

Li²,

Li³

et al. 2014

ORL

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Aims: To explore the clinical characteristics and treatment of malignant minor salivary gland carcinomas of the larynx. Methods: Clinical patient information regarding presentation, pathology, treatment and outcome was obtained through a review of patient charts. Results: Malignant minor salivary carcinomas in the larynx were confirmed pathologically in 15 patients (11 males, 4 females) between 2003 and 2010 in our hospital; 6 patients had mucoepidermoid carcinoma (MEC; 40%), 6 had adenoid cystic carcinoma (ACC; 40%) and 3 had adenocarcinoma (20%). The most common tumour location was the subglottis (60%), followed by the supraglottis (33%). In total, 13 patients underwent surgery, of which 10 (77%) had positive/insufficient resection margins. The mean follow-up time was 42.3 months, with a range of 8-129 months. The 3- and 5-year overall survival rates were 46.7 and 20%, respectively. Conclusion: Malignant minor salivary gland carcinoma of the larynx is a rare disease that showed male predominance in our study. The carcinomas were most often localised in the subglottic region, and the most common histological types were ACC and MEC. Wide-margin surgery with postoperative radiotherapy is advocated. The overall prognosis is poor compared to squamous cell carcinomas of the same location and tumour stage.

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Section: Discussionmentioning

confidence: 67%

Malignant Minor Salivary Gland Carcinomas of the Larynx

Zhang¹,

Li²,

Li³

et al. 2014

ORL

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“…According to these data, however, LAdC NOS has a different geographical predilection, primarily affecting the supraglottis. This difference may be attributable to the increased number of submucosal salivary glands present in this region compared to the glottis …”

Section: Discussionmentioning

confidence: 99%

“…This difference may be attributable to the increased number of submucosal salivary glands present in this region compared to the glottis. 13…”

Section: Regional/anatomical Characteristicsmentioning

confidence: 99%

Laryngeal adenocarcinoma not otherwise specified: A population‐based perspective

et al. 2016

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“…This is a very rare malignant tumor of the minor salivary gland accounting for <1% of all laryngeal tumors. 39 40 It is thought to arise from the submucosal glands, which make them to present late. It is commonly seen in subglottic location, followed by the supraglottic and then glottis.…”

Section: Discussionmentioning

confidence: 99%

Malignant tumors of the larynx: Clinicopathologic profile and implication for late disease presentation

et al. 2016

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Background:Malignant laryngeal tumors are uncommon. Late presentation of the disease may worsen management outcomes. We described the epidemiologic, clinicopathologic profile, and management outcomes of laryngeal tumors in a tertiary health institution in Nigeria.Materials and Methods:An 11-year retrospective review of medical records of patients managed for malignant laryngeal tumor at the University College Hospital, Ibadan, Nigeria, was performed.Results:There were 97 patients comprising 74 (76.3%) males and 23 (23.7%) females with a mean age of 60.48 ± 12.15 years. The mean duration of illness was 7.3 ± 3.8 months. History of cigarette smoking and alcohol consumption was in 2.1% and 14.4% patients, respectively. The most common clinical presentations were hoarseness, cough, and dyspnea. Transglottis (91.8%) was the most common anatomic tumor location and 92.8% patients presented in advanced disease stage. Four histologic types were identified with squamous cell carcinoma accounting for 96.9%. About 92% patients had emergency tracheostomy and 56 (57.7%) patients had total laryngectomy. The postoperative complications were pharyngocutaneous fistula (5.2%) and peristomal recurrence (3.1%). The 5-year survival rate was 52.5%.Conclusions:Malignant laryngeal tumors are uncommon, but more females are getting the disease. Squamous cell carcinoma is the most common histologic variant. Late stage disease presentation and initial wrong diagnosis contributed to the poor management outcome.

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Salivary gland carcinomas of the larynx: A national study in Denmark

Cited by 30 publications

References 14 publications

Malignant Minor Salivary Gland Carcinomas of the Larynx

Malignant Minor Salivary Gland Carcinomas of the Larynx

Laryngeal adenocarcinoma not otherwise specified: A population‐based perspective

Malignant tumors of the larynx: Clinicopathologic profile and implication for late disease presentation

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