Salivary fibronectin in man: An immunoblotting, radioimmunoassay and immunohistochemical study

Kanehisa, Junya; Doi, Satoshi; Yamanaka, Takenori; Takeuchi, Hiroshi

doi:10.1016/0003-9969(91)90096-d

Cited by 12 publications

(6 citation statements)

References 21 publications

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“…Pierschbacher et al [16] demonstrated that ¢bro-nectin is fragmented into three domains, cell attachment-and gelatin-and heparin-binding domains, by chymotrypsin. Several studies have shown the presence of fragmented domains of ¢bronectin in saliva and crevicular £uid [17,18], and we detected by Western blot analysis the presence of two domainbearing fragments in saliva of healthy subjects and adult periodontal patients (unpublished data). As our previous studies showed that ¢bronectin binds to P. gingivalis ¢mbriae via its cell attachment-and heparin-binding domains [2,4,6,7], these two domains in saliva may be involved in inhibition of the ¢mbria-induced expression of the KC gene in macrophages observed in this study.…”

Section: Discussionmentioning

confidence: 71%

Fibronectin in saliva inhibits Porphyromonas gingivalis fimbria-induced expression of inflammatory cytokine gene in mouse macrophages

Murakami

1998

FEMS Immunology and Medical Microbiology

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The aim of this study was to examine whether fibronectin in saliva plays a regulatory role in Porphyromonas gingivalis fimbria-mediated pathogenesis in adult periodontal disease. Our previous study demonstrated that fibronectin is one of the binding proteins of P. gingivalis fimbrillin. In the present study, we observed that fibronectin in saliva binds specifically to the fimbrillin. The fibronectin content in saliva of adult periodontal patients was significantly lower than that of healthy subject. In addition, the inhibitory action of salivary fibronectin from adult periodontal patients toward P. gingivalis fimbria-induced expression of the neutrophil chemoattractant KC gene in mouse macrophages was clearly weak compared with that of the fibronectin from healthy subjects. These results suggest that fibronectin in saliva plays an important role as a regulator in the pathogenesis of P. gingivalis fimbriae in adult periodontal disease.

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Section: Discussionmentioning

confidence: 71%

Fibronectin in saliva inhibits Porphyromonas gingivalis fimbria-induced expression of inflammatory cytokine gene in mouse macrophages

Murakami

1998

FEMS Immunology and Medical Microbiology

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“…It is therefore possible that these molecules, when present in gingival crevicular fluid or saliva, may modulate wound healing of gingiva. Indeed, fibronectin has been found both in crevicular fluid and saliva (112,129,257). Even though not yet reported, it is reasonable to assume that other adhesion molecules may be present in saliva.…”

Section: Role Of Saliva and Gingival Crevicular Fluid In Oral Wound Hmentioning

confidence: 99%

Cell biology of gingival wound healing

HÄKKINEN¹,

Uitto²,

Larjava³

2000

Periodontol 2000

194

127

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“…However, a recent study reported that the amount of fibronectin in saliva remained constant, even after gingival health improved (Tynelius-Bratthall, 1988). This may be explained by the fact that fibronectin is released by salivary gland ductal cells into saliva (Kanehisa et al, 1991).…”

Section: Fibronectinmentioning

confidence: 99%

Saliva-Bacterium Interactions in Oral Microbial Ecology

Scannapieco

1994

Critical Reviews in Oral Biology & Medicine

283

250

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Saliva is thought to have a significant impact on the colonization of microorganisms in the oral cavity. Salivary components may participate in this process by one of four general mechanisms: binding to microorganisms to facilitate their clearance from the oral cavity, serving as receptors in oral pellicles for microbial adhesion to host surfaces, inhibiting microbial growth or mediating microbial killing, and serving as microbial nutritional substrates. This article reviews information pertinent to the molecular interaction of salivary components with bacteria (primarily the oral streptococci and Actinomyces) and explores the implications of these interactions for oral bacterial colonization and dental plaque formation. Knowledge of the molecular mechanisms controlling bacterial colonization of the oral cavity may suggest methods to prevent not only dental plaque formation but also serious medical infections that may follow microbial colonization of the oral cavity.

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Salivary fibronectin in man: An immunoblotting, radioimmunoassay and immunohistochemical study

Cited by 12 publications

References 21 publications

Fibronectin in saliva inhibits Porphyromonas gingivalis fimbria-induced expression of inflammatory cytokine gene in mouse macrophages

Fibronectin in saliva inhibits Porphyromonas gingivalis fimbria-induced expression of inflammatory cytokine gene in mouse macrophages

Cell biology of gingival wound healing

Saliva-Bacterium Interactions in Oral Microbial Ecology

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