Salivary Eosinophil Cationic Protein in Allergic Rhinitis

Kırgezen, Tolga; Server, Ela Araz; Turanoğlu, Fulya Savran; Yiğit, Özgür; Uzun, Hafize; Durmuş, Sinem

doi:10.5152/tao.2019.4127

Cited by 6 publications

(10 citation statements)

References 17 publications

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“…22 ECP is found in various body fluids such as serum, plasma, sputum, saliva, nasal secretions and urine, and its level increases in atopic conditions such as arthritis rheumatoid, recurrent wheezing as well as in chronic infections such as chronic rhinosinusitis. 7 The association between ECP levels and oral lesions has been less studied. One study showed that salivary ECP levels in patients with recurrent aphthous stomatitis were significantly higher than in healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

“…Another biomarker that has been evaluated in some allergic conditions is the eosinophil cationic protein (ECP), a nonspecific marker released by eosinophils in allergic reactions, which is found in plasma, saliva, urine, nasal secretions, and other body fluids. 7 The biological activities of ECP include the suppression of the proliferative responses of T cells, the synthesis of immunoglobulin by B cells, the degranulation of mast cells, the regulation of fibroblast activity, the stimulation of airway mucus secretion, and the disruption of the coagulation and complement system. However, the most important function of ECP is cytotoxic activity against bacteria, fungi, viruses, and respiratory epithelial and cancer cells.…”

Section: Introductionmentioning

confidence: 99%

“…The cytotoxic activity of ECP is exerted by the formation of pores in the cell membrane to penetrate water and small molecules into the cell and lead to the osmotic lysis of the target cell. 8,9 ECP plays an important role in the pathogenesis of some atopic conditions such as allergic rhinitis, 7 and its level may increase in allergic conditions such as recurrent wheezing 10 and rhinosinusitis. 11 Kirgezen et al found in their 2019 study on patients with allergic rhinitis that the IgE D2 levels were higher in patients than in controls, and that the salivary and serum ECP levels were not significantly different.…”

Section: Introductionmentioning

confidence: 99%

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Salivary Atopy Biomarkers in Patients with Geographic Tongue

Farhad-Mollashahi

Dalirsani

Honarmand

et al. 2021

European Journal of General Dentistry

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Objectives Geographic tongue is the mucositis of the dorsal surface of the tongue with no definite etiology, although it may be associated with atopic conditions. In this study, the salivary immunoglobulin E (IgE) and eosinophilic cationic protein (ECP) levels were assessed in patients with geographic tongue to examine the relationship between this condition and allergy-related biomarkers. Materials and Methods In this case-control study, unstimulated saliva was collected from 45 geographic tongue patients and 45 controls, and the salivary IgE and ECP levels were assessed. The data were analyzed with SPSS 20.0 using the Mann–Whitney test with a significance level of p < 0.05. Results The salivary IgE level in the case and control groups was 123.76 ± 8.1 and 74.34 ± 6.2 IU/mL, respectively, and the salivary ECP level was 9.4 ± 6.0 and 7.6 ± 3.2 ng/mL, respectively. There was a statistically significant difference between the two groups in terms of salivary IgE (p = 0.007) and ECP (p = 0.001) levels. Conclusion Salivary IgE and ECP levels increase in patients with geographic tongue. They can, therefore, be used for the initial diagnostic workup and to investigate the possible association of geographic tongue with allergic reactions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Salivary Atopy Biomarkers in Patients with Geographic Tongue

Farhad-Mollashahi

Dalirsani

Honarmand

et al. 2021

European Journal of General Dentistry

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“…До настоящего времени не известны причины формирования новых эндотипов аллергического ринита. Возможно, это связано с особенностями эозинофильного воспаления [4][5][6], эпигеномными нарушениями [7], отличительными чертами иннервации различных аллергических органов-мишеней [8], т. к. установлено, что своеобразные аллергические эндотипы встречаются только в пределах органов респираторного тракта и конъюнктив. С целью дифференциальной диагностики эндотипов аллергического ринита были исследованы ключевые аллергологические показатели в смешанной группе пациентов.…”

Section: Introductionunclassified

Differentiating the endotypes in allergic rhinitis

Klimov

Салахутдинова

Пронина

et al. 2021

SMJ

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Aim. The aim of the study was to differentiate the endotypes in allergic rhinitis by key allergy markers in a mixed group of patients.Material and Methods. The study comprised a total of 48 patients, men and women, aged 18-60 years suffering from three endotypes of allergic rhinitis including the classic, local, and dual allergic rhinitis. The standard diagnostics of allergic rhinitis included taking a history of allergies, family history of allergic disease, video rhinoscopy, serum total IgE level assessment, allergy skin tests to house dust mite and pollen allergens, and study of eosinophilic inflammation parameters (eosinophil cationic protein, interleukin-5 (IL5), and eosinophil counts in blood and nasal secretion).Results. Based on total IgE level, the general group of patients was divided to two subgroups: subgroup 1 comprised patients with high IgE level (n = 22); subgroup 2 comprised patients with low IgE level (n = 26). Most of patients in these groups had contradictory results of allergy skin tests i.e. positive allergy skin test results in case of high IgE level (group 1) and vice versa. Cluster analysis-based exminations of general group allowed to categorize three subgroups of patients: patients with classic allergic rhinitis (n = 22), local allergic rhinitis (n = 22), and dual allergic rhinitis (n = 4). Besides, an increased rate of anxiety disorder was found in patients with local allergic rhinitis (p < 0.001).Conclusion. The obtained data showed promise for a new research trend in studying allergic rhinitis endotypes, namely: investigation of neuroimmune relationships in allergic tolerance disruption in the presence of this pathology.

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“…Total IgE levels [ 11 , 12 ] and eosinophil counts [ 11 – 13 ] are expected to increase in the blood during bronchial asthma attacks. Serum eosinophil cationic protein (ECP) [ 11 – 14 ] is an inflammatory marker released from eosinophils and is a major finding in attacks of bronchial asthma, in which the levels of ECP may increase [ 14 , 15 ].…”

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confidence: 99%

Retrospective evaluation of the effects of Sugammadex and Neostigmine on the IgE and Eosinophil Cationic Protein in Morbid Obese Patients

Görgülü

Koşar

2020

North Clin Istanbul

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OBJECTIVE: This study was designed to show that allergic reactions with gamma cyclodextrin-related caused by sugammadex are not anaphylaxis but an anaphylactoid reaction. METHODS: In this retrospective study, 83 morbidly obese patients, who underwent elective laparoscopic sleeve gastrectomy operation, were included. Patient data were obtained from patient files and electronic health records system (SARUS). The patients were divided into two groups as sugammadex (Group S) and neostigmine (Group N). Patient data were recorded, including patient preoperative demographics (age, gender) and preoperative and postoperative (12 hours later) levels of total IgE and ECP (Eosinophil cationic protein) levels. RESULTS: There was not a significant change in the total IgE levels in Group S or Group N (p>0.05); however, the levels of ECP significantly decreased in both groups (p<0.001, p=0.01). In the patients in Group S, the preoperative levels of total IgE were significantly positively, and weakly correlated with the preoperative ECP (p=0.311, p=0.045) and postoperative ECP (p=0.310, p=0.046) levels. CONCLUSION: Allergic reactions that arise from sugammadex related with gamma-cyclodextrin are non-IgE mediated anaphylactoid reactions. Anaphylactoid reaction was not observed after administration of 2 mg kg - 1 sugammadex intravenously in patients with morbid obesity.

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Salivary Eosinophil Cationic Protein in Allergic Rhinitis

Cited by 6 publications

References 17 publications

Salivary Atopy Biomarkers in Patients with Geographic Tongue

Salivary Atopy Biomarkers in Patients with Geographic Tongue

Differentiating the endotypes in allergic rhinitis

Retrospective evaluation of the effects of Sugammadex and Neostigmine on the IgE and Eosinophil Cationic Protein in Morbid Obese Patients

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