Salivary duct carcinoma: evaluation of treatment and outcome in a tertiary referral institute

Beck, Ann Jean C.C.; Lohuis, Peter J. F. M.; Al‐Mamgani, Abrahim; Smit, Laura A.; Klop, W. Martin C.

doi:10.1007/s00405-018-5000-x

Cited by 17 publications

(12 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In comparison with previous studies concerning the survival benefit of adjuvant therapy for SDC, our study verified the role of radiotherapy and chemotherapy in improving the prognosis in patients with SDC, which might provide new support for the establishment of therapeutic guidelines for this disease (9,15,17). However, more clinical trials are needed to further investigate the survival benefits of the addition of To date, the commonly identified prognostic factors of SDC are as follows: age, gender, tumor grade, tumor size, lymph node metastasis and clinical stage (9)(10)(11)(12). The prognostic factors determined in our study were similar to those expected based on prior studies.…”

Section: Discussionsupporting

confidence: 67%

“…The most commonly identified prognostic factors of SDC include age, gender, tumor grade, tumor size, lymph node metastasis and clinical stage (9)(10)(11)(12). Some other factors such as increasing numbers of positive lymph nodes, lymph node ratio (LNR), lymph-vascular invasion, perineural invasion and HER2/neu receptor expression were also shown to influence the prognosis of SDC (8,13,14).…”

Section: Original Articlementioning

confidence: 99%

“…Some other factors such as increasing numbers of positive lymph nodes, lymph node ratio (LNR), lymph-vascular invasion, perineural invasion and HER2/neu receptor expression were also shown to influence the prognosis of SDC (8,13,14). However, due to the rarity of this disease, most of those studies focused on single-center studies with limited sample size (1,12,15,16). Therefore, the prognostic factors for SDC still remain to be largely elucidated.…”

Section: Original Articlementioning

confidence: 99%

See 2 more Smart Citations

A population-based competing risk survival analysis of patients with salivary duct carcinoma

Ran

Huixian

et al. 2020

Ann Transl Med

View full text Add to dashboard Cite

Background: Salivary duct carcinoma (SDC) is a rare malignancy with high risk of local recurrence and distant metastases of the salivary gland. This study was designed to summarize the clinical and pathological features and to further evaluate them as potential prognostic factors for SDC in the salivary gland. Methods: Clinical data of 266 patients diagnosed with SDC between 2004 and 2015 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. The prognostic factors affecting overall survival (OS) and cancer-specific survival (CSS) were determined by Kaplan-Meier analyses and Cox proportional hazards model. The nomogram was established to predict OS and CSS for SDC. The predictive accuracy of the nomograms was measured by concordance index (C-index). Results: The 3-and 5-year OS of SDC patients were 67.41% and 47.86%, while the 3-and 5-year CSS were 84.6% and 60.7%, respectively. The primary site, T stage and M stage were identified as independent prognostic factors for OS by the multivariate analysis, whereas N stage, M stage, the presence of multiple primary carcinomas and the treatment modalities were identified as independent prognostic factors for CSS. The C-index values of the prognostic nomogram based the risk factors affecting SDC OS and CSS were 0.703 (0.646-0.760) and 0.771 (0.691-0.851), respectively. Conclusions: SDC is an aggressive malignancy with a high proportion of advanced stage and lymph node metastases. Patients with increasing age, submandibular gland malignancy, advanced T stage, advanced N stage, advanced M stage, high lymph node ratio (LNR) and the presence of multiple primary carcinomas tend to have unfavorable outcomes. Radiotherapy or chemotherapy improve CSS remarkably. These factors will aid in effective therapeutic treatment modalities for SDC.

show abstract

Section: Discussionsupporting

confidence: 67%

Section: Original Articlementioning

confidence: 99%

Section: Original Articlementioning

confidence: 99%

See 1 more Smart Citation

A population-based competing risk survival analysis of patients with salivary duct carcinoma

Ran

Huixian

et al. 2020

Ann Transl Med

View full text Add to dashboard Cite

show abstract

“…Kleinsasser et al [19] described SDC in 1968, as an aggressive adenocarcinoma which resembles high-grade breast ductal carcinoma. This entity has been increasingly diagnosed, and there is currently a growing interest from the scientific community, with multiple publications of institutional series [20][21][22][23][24][25][26][27][28][29][30]. Actually, SDC is characterised by a very aggressive behaviour, with high rates of local or distant recurrence and tumour-related death [31,32].…”

Section: Discussionmentioning

confidence: 99%

A 10-year review of primary major salivary gland cancers

Cruz¹,

Magalhães²,

Pereira³

et al. 2020

ecancer

View full text Add to dashboard Cite

Primary salivary gland cancers comprise a heterogeneous group of histological entities and represent less than 5% of head and neck malignancies. Surgical resection is the main treatment, and adjuvant radiotherapy is performed in selected cases. Chemotherapy is an option in metastatic or recurrent disease, with poor evidence. We aimed to review a 10-year experience of a cancer centre on major salivary gland cancers, focusing on clinical, pathological, treatment and patients' outcomes data. A total of 93 patients were identified, median age at diagnosis was 64 years (IQR, 23), and 51.6% were male. The parotid gland was the site of origin in 76.3% of cases. The most frequent histological type was salivary duct carcinoma (21.5%). All patients were submitted to surgery and adjuvant radiotherapy was performed in 74.2%. From 26 patients diagnosed with metastatic disease, 9 were treated with systemic therapy. At 8 years, disease-free survival was 54.6% and overall survival was 48.4%. Male sex, salivary duct carcinoma, stage pT3-4, stage pN2-3, high histologic grade, lymphovascular invasion and perineural invasion were negative prognostic indicators for disease-free survival and overall survival. Extracapsular spread was a negative prognostic indicator for overall survival. In the multivariable analysis, histological type-salivary duct carcinoma-kept significant negative impact in disease-free survival and high histologic grade in overall survival. The most frequent histological type was salivary duct carcinoma, which is estimated to represent only 9% of salivary tumours. Patients with salivary duct carcinoma relapsed more than other histological types. High histologic grade was a negative prognostic indicator for overall survival.

show abstract

“…This is of particular concern because the nature of this neoplasm necessitates aggressive clinical intervention. An erroneous low‐grade diagnosis may lead to inadequate, conservative surgical management in a neoplasm where early, accurate diagnosis and appropriate treatment is key 4 . Many studies have focused on the significant variation in this tumor morphology and presentation 5 .…”

Section: Introductionmentioning

confidence: 99%

Oncocytic features in salivary duct carcinoma, a potential pitfall for misdiagnosis as Warthin tumor in fine needle aspiration specimens: A cytomorphologic analysis of 14 cases

Goswami

Zhang

Vahidi

et al. 2020

Diagnostic Cytopathology

View full text Add to dashboard Cite

Background Salivary duct carcinoma (SDC) is an uncommon and highly aggressive primary salivary gland neoplasm. Cytomorphologic features of SDC include cellular smears, nuclear atypia, prominent nucleoli, cribriform and papillary architecture, and background necrosis. The presence of oncocytic features has been described but not adequately characterized in the current literature. Method This study cohort consisted of 14 cases of histologically proven SDC with previous salivary gland fine needle aspiration (FNA). The cytologic material of each case was semi‐quantitatively analyzed and evaluated for various cytomorphologic, architectural, and background features. Results Twelve SDCs were located in the parotid gland and two in the submandibular gland. In two cases the initial cytologic diagnoses was Warthin tumor or favor Warthin tumor. Moderate to marked degree of oncocytic changes were noted in all cases except one case. Nuclear atypia was variable with most cases exhibiting moderate to high‐grade nuclear features, while four cases demonstrated low‐grade nuclear cytomorphology. Cytoplasmic vacuolation was seen in nine cases and variable amount of background necrosis was observed in eight cases. Cribriform and papillary architecture was recognized in only six cases. Background lymphocytes were absent in all but one case. Conclusions Precise diagnosis of SDC based on cytomorphologic features alone can be challenging. Oncocytic change is one of the most consistent features observed in this case series and when associated with less pronounced cytologic atypia, can potentially lead to misdiagnosis as Warthin tumor. SDC should be considered in the differential diagnosis of oncocytic salivary gland neoplasms where precise diagnosis is not possible.

show abstract

Salivary duct carcinoma: evaluation of treatment and outcome in a tertiary referral institute

Cited by 17 publications

References 30 publications

A population-based competing risk survival analysis of patients with salivary duct carcinoma

A population-based competing risk survival analysis of patients with salivary duct carcinoma

A 10-year review of primary major salivary gland cancers

Oncocytic features in salivary duct carcinoma, a potential pitfall for misdiagnosis as Warthin tumor in fine needle aspiration specimens: A cytomorphologic analysis of 14 cases

Contact Info

Product

Resources

About