Salivary duct carcinoma: Clinicopathologic and immunohistochemical review of 26 cases

Lewis, Jean E.; McKinney, Barbara C.; Weiland, Louis H.; Ferreiro, Jorge A.; Olsen, Kerry D.

doi:10.1002/(sici)1097-0142(19960115)77:2<223::aid-cncr1>3.0.co;2-n

Cited by 261 publications

(222 citation statements)

References 29 publications

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“…LG-SDC and conventional SDC are composed of neoplastic cells with ductal phenotype and varying degree of apocrine differentiation and AR expression [1,6,14,31,41] but exhibit significant clinicopathologic differences including the expression of S100 protein, with 84 % of LG-SDCs positive for S100 protein. In contrast, the data regarding S100 protein expression in conventional SDC is more controversial with Lewis et al [30] reporting expression in only 4 % while Brandwein et al [42] reported reaction in 100 % of cases. The presence of at least focal LG-SDC has not been described in any study of conventional SDC.…”

Section: Discussionmentioning

confidence: 97%

“…It occurs mostly in elderly patients, has a male predilection and usually present as a rapidly growing tumor in the parotid gland. Unlike LG-SDC, it is notorious for early distant metastases and high mortality [30]. SDC resembles high grade ductal carcinoma of breast, with both intraductal and widely invasive components.…”

Section: Conventional Salivary Duct Carcinomamentioning

confidence: 99%

“…Comedonecrosis, perineural invasion and lymph-vascular tumor emboli are very common. By immunohistochemisty, the tumor cells are positive for AR and GCDFP-15 [31], and usually negative for S100 protein [30].…”

Section: Conventional Salivary Duct Carcinomamentioning

confidence: 99%

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Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Kuo¹,

Weinreb²,

Perez-Ordonez³

2013

Head and Neck Pathol

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Low-grade salivary duct carcinoma (LG-SDC) is a rare neoplasm characterized by predominant intraductal growth, luminal ductal phenotype, bland microscopic features, and favorable clinical behavior with an appearance reminiscent of florid to atypical ductal hyperplasia to low grade intraductal breast carcinoma. LG-SDC is composed of multiple cysts, cribriform architecture with ''Roman Bridges'', ''pseudocribriform'' proliferations with floppy fenestrations or irregular slits, micropapillae with epithelial tufts, fibrovascular cores, and solid areas. Most of the tumor cells are small to medium sized with pale eosinophilic cytoplasm, and round to oval nuclei, which may contain finely dispersed or dark condensed chromatin. Foci of intermediate to high grade atypia, and invasive carcinoma or micro-invasion have been reported in up to 23 % of cases. The neoplastic cells have a ductal phenotype with coexpression of keratins and S100 protein and are surrounded by a layer of myoepithelial cells in noninvasive cases. The main differential diagnosis of LG-SDC includes cystadenoma, cystadenocarcinoma, sclerosing polycystic adenosis, salivary duct carcinoma in situ/highgrade intraductal carcinoma, and papillary-cystic variant of acinic cell carcinoma. There is no published data supporting the continuous classification of LG-SDC as a variant of cystadenocarcinoma. Given that most LG-SDC are noninvasive neoplasms; the terms ''cribriform cystadenocarcinoma'' and LG-SDC should be replaced by ''low-grade intraductal carcinoma'' (LG-IDC) of salivary gland or ''lowgrade intraductal carcinoma with areas of invasive carcinoma'' in those cases with evidence of invasive carcinoma.

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Section: Discussionmentioning

confidence: 97%

Section: Conventional Salivary Duct Carcinomamentioning

confidence: 99%

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Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Kuo¹,

Weinreb²,

Perez-Ordonez³

2013

Head and Neck Pathol

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“…SDC is a distinctive but relatively common high grade adenocarcinoma arising from the excretory ductal epithelium of the major salivary glands, especially the parotid gland [8-10]. Clinically, these tumors are characterized by aggressive (i.e., infiltrative and destructive) behavior with local recurrence, early and distant metastasis, invasion of the facial nerve, and/or significant mortality [8-11].…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, these tumors are characterized by aggressive (i.e., infiltrative and destructive) behavior with local recurrence, early and distant metastasis, invasion of the facial nerve, and/or significant mortality [8-11]. Histopathologically, SDCs have a striking resemblance to ductal carcinoma of the breast, exhibiting intraductal and infiltrating components [8,10,11]. In addition, very intriguingly, they should show a broader clinicopathological spectrum and many cases of them may develop within PA as a result of malignant transformation of ductal epithelial cells [9,12].…”

Section: Introductionmentioning

confidence: 99%

Invasive salivary duct carcinoma ex pleomorphic adenoma of the parotid gland: a teaching case giving rise to the genuine diagnostic difficulty on an inadequate cytology specimen

et al. 2012

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A history of a recent rapid increase in long-standing swelling mass was presented in the right parotid gland of an 85-year-old male. The inadequate cytologic specimens contained few small clusters of three-dimensional malignant epithelial cells having hyperchromatic pleomorphic nuclei and prominent nucleoli, adjacent to a cluster of benign monomorphic myoepithelial cells. We first interpreted it merely as an adenocarcinoma, not otherwise specified. A radical parotidectomy was performed, and gross examination revealed an encapsulated and firm tumor lesion, looking grayish-blue to yellowish-white, focally associated with extracapsular invasion. On microscopic examination, the tumor was predominantly composed of a proliferation of highly atypical epithelial cells having abundant eosinophilic cytoplasm, often arranged in a Roman-bridge appearance with foci of comedo necrosis, alternating with extensive infiltration to adjacent stroma in a trabecular or alveolar fashion with severe vessel permeation. Within the background of pleomorphic adenoma, the carcinoma cells sometimes replaced ductal luminal cells while retaining an intact-like myoepithelial layer. Therefore, we finally made a diagnosis of invasive salivary duct carcinoma ex pleomorphic adenoma. We should be aware that owing to its characteristic features, cytopathologists might be able to determine correct diagnosis, based on multiple and adequate samplings.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2126158270695815

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Aryepiglottic Abscess Manifesting as Epiglottitis

Daniel

Nader²,

Kost³

et al. 2009

Arch Otolaryngol Head Neck Surg

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We report an unusual case involving a patient with sweat gland carcinoma of the cheek who presented with ipsilateral neck lymph node metastasis 10 years after his initial presentation. Pathological analysis of the surgical specimen revealed a strong reactivity of tumor cells to gross cystic disease fluid protein 15, estrogen receptor protein, and progesterone receptor protein. On the basis of these results, tamoxifen citrate therapy was initiated empirically. Our patient has been disease free for more than 3 years. Based on this and another case reported in the literature, we believe that antiestrogen therapy could prove beneficial in a subset of patients with sweat gland carcinoma. We recommend future multicenter clinical trials to assess the effectiveness of postoperative tamoxifen therapy for patients with estrogen and progesterone receptor protein-positive metastatic sweat gland carcinoma.

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Salivary duct carcinoma: Clinicopathologic and immunohistochemical review of 26 cases

Abstract: The prognosis for SDC is dismal, and clinically useful prognostic factors were not found. Our results do not confirm hormonal concordance between SDC and breast carcinoma.

Cited by 261 publications

References 29 publications

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Invasive salivary duct carcinoma ex pleomorphic adenoma of the parotid gland: a teaching case giving rise to the genuine diagnostic difficulty on an inadequate cytology specimen

Aryepiglottic Abscess Manifesting as Epiglottitis

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