Salivary Duct Carcinoma: An Analysis of Four Cases with Review of Literature

Abstract

Salivary duct carcinoma (SDC) is a histologically distinctive neoplasm of the parotid gland. The criteria for the diagnosis of SDC are circumscribed epithelial nests having a papillary, cribriform, and/or solid architecture coupled with central necrosis. The infiltrating cancer can be papillary, resembling the intraductal component or have a nonspecific, undifferentiated pattern. The authors are presenting four cases and compare them with 11 other acceptable cases from the literature. The neoplasm occurs beyond the age of 50 (median 63 years) and has a dismal prognosis with nearly two-thirds of the patients developing distant metastases. All surviving patients have been treated with combined parotidectomy and radiotherapy.

Salivary Duct Carcinoma

“…26 Salivary duct carcinoma comprises 0.5-3.9% of salivary gland carcinomas. 7,11,16,27 It is generally a high grade carcinoma with a tendency for early metastasis and a poor prognosis. [1][2][3][4][5]10,13,16,18,21,23,27 Although patients have ranged in age from 22 to 91 years, the peak incidence is in the sixth and seventh decades.…”

“…[1][2][3][4][5]10,13,[16][17][18]21,23,27 Early diagnosis and treatment appear to be important as this tumor is known to metastasize early. 2,4,7,10,27 Although …”

Submandibular Gland Adenocarcinoma of Intercalated Duct Origin in Smgb-Tag Mice

“…1985) and Wharton's duct (Dardick 1996b), but are more often a component of salivary duct carcinoma (Brandwein et al, 1990;Garland et al, 1984;Hui et al, 1986). In situ carcinoma is also part of the cytologic and histologic spectrum of carcinoma ex pleomorphic adenoma (Brandwein et al, 1996;LiVolsi and Perzin, 1977;Yamamoto et al, 1996Yamamoto et al, , 1998.…”

Image interpretation for squamous cell carcinoma of Stensen duct

“…In addition to these cases, a histological group of ductal carcinomas comprising a variant of primary parotid gland carcinoma has also been reviewed as "Stensen's duct carcinoma". 7,12 Furthermore, the term "salivary duct carcinoma" has been used to describe such unusual tumors arising within the substance of the parotid gland, [17][18][19][20] with these tumors sharing many of the histopathological characteristics of "ductal carcinomas", such as intraductal mammary and prostatic carcinomas. Ductal carcinoma usually presents as a parotid gland swelling and arises from the larger ducts in the parotid gland.…”