Salivary Diagnostics in Oral Cancer

Sridharan, Gokul

doi:10.5772/30412

Cited by 2 publications

(3 citation statements)

References 46 publications

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“…[ 10 ] A large number of proteinous tumor markers are available in the market, but none is very specific. [ 4 5 10 ] Hence, an attempt has been made to find out a marker based on oligosaccharides which result due to alteration of the carbohydrate structure in the cancer cells. The first successful report was based on n-glycosylation at a specific Asn residue of a glycoprotein in cases of pancreatic carcinoma, one of the most difficult cancers to diagnose.…”

Section: Discussionmentioning

confidence: 99%

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Fucose: A biomarker in grading of oral cancer

Kumar¹,

Saxena²,

Srinivas³

et al. 2015

Natl J Maxillofac Surg

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Introduction:Early diagnosis of cancer helps a great deal in the management of oral cancer patients. Number of proteinous markers have been employed for this purpose. Majority of them are not specific. Recently conjugated oligosaccharide with proteins and lipids have gained considerable importance in the present postgenomics and postproteomic period in the diagnostic and prognostics of cancer cases.Materials and Methods:In this study, serum fucose levels were estimated in 50 control cases and 75 cases of oral cancer by the method of Dische and Shettles as adopted by Winzler.Results:Serum fucose levels were found to be significantly higher in oral cancer cases (46.63 ± 5.29 mg/dl) as compared to the control cases (7.22 ± 0.26 mg/dl). The stepwise elevated serum fucose levels were found to be correlated with the histopathological grading of oral cancer.Conclusions:Estimation of such fucose conjugated proteins is suggestive to be good biomarkers in the diagnosis of oral cancer cases as well as in assessing the prognosis of such cases.

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Section: Discussionmentioning

confidence: 99%

“…Several molecular markers have been used for the identification of oral cancer. [ 4 5 ] Currently, estimation of conjugated oligosaccharide with proteins and lipids has gained considerable importance that is associated with cell division or oncogenesis. [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

Fucose: A biomarker in grading of oral cancer

Kumar¹,

Saxena²,

Srinivas³

et al. 2015

Natl J Maxillofac Surg

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“…These advancements in technology have helped saliva to move beyond oral health to where it can now be used to assess the overall health. [ 2 ]…”

Section: Introductionmentioning

confidence: 99%

Lab on a Chip: Conquer disease at the earliest

et al. 2018

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Oral cancer is the fifth most common cancer in the world, accounting for numerous deaths annually. The 5-year survival rate remains approximately 50% for oral squamous cell carcinoma (OSCC) in the past several decades. Early detection plays a vital role in the survival rate of the patients. There is no accurate, cost-effective, and reliable method for the screening of patients with OSCC. Hence, many patients are diagnosed at advanced stages. Early detection would, therefore, help to identify patients and modify treatment with close monitoring. Lab on a Chip or micro-total-analysis systems are one of the microfluidics technologies that are defined as adaptation, miniaturization, integration, and automation of analytical laboratory procedures into a single device or “chip.” This technology assures the replacement of complicated techniques with miniaturized, integrated, programmed, and economical diagnostic devices. Hence, this system provides a means for rapid, automated, molecular analysis of cancer cells.

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Salivary Diagnostics in Oral Cancer

Cited by 2 publications

References 46 publications

Fucose: A biomarker in grading of oral cancer

Fucose: A biomarker in grading of oral cancer

Lab on a Chip: Conquer disease at the earliest

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