2013
DOI: 10.5455/medarh.2013.67.374-377
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Salivary Cortisol Levels as a Biological Marker of Stress Reaction

Abstract: Although, the studies on correlation between saliva cortisol concentrations and free levels of this hormone in blood samples are lacking, salivary cortisol offer a novel approach in research of stress biomarkers with its ease of collection and potentially wide scope for application.

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Cited by 169 publications
(147 citation statements)
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“…Specifically, saliva contains free, biologically active cortisol as opposed to total cortisol present in serum or plasma. Importantly, the concentration of cortisol in saliva is independent of the salivary flow rate and is strongly correlated with serum cortisol concentrations (Bozovic, Racic, & Ivkovic, 2013). Salivary cortisol levels increase 5 minutes after an increase in plasma levels and are strongly correlated with plasma levels (Lucassen & Cizza, 2012).…”
Section: Introductionmentioning
confidence: 92%
“…Specifically, saliva contains free, biologically active cortisol as opposed to total cortisol present in serum or plasma. Importantly, the concentration of cortisol in saliva is independent of the salivary flow rate and is strongly correlated with serum cortisol concentrations (Bozovic, Racic, & Ivkovic, 2013). Salivary cortisol levels increase 5 minutes after an increase in plasma levels and are strongly correlated with plasma levels (Lucassen & Cizza, 2012).…”
Section: Introductionmentioning
confidence: 92%
“…Sampling of saliva does not induce pain or stress, and because of the stability of cortisol in saliva, samples can be kept at room temperature for up to 4 wk (43). Transfer of cortisol from blood to saliva is a fast process (2 to 3 min); therefore, this method can detect acute variations in blood levels and circadian rhythm (43). Hair cortisol levels have been used to monitor long-term stress levels.…”
Section: Indicators Of Hpa Axis Activitymentioning
confidence: 99%
“…Salivary cortisol is the free and biologically active form of this hormone, and sample collection is simple, safe and non-invasive, as it can be made even in the participant's workplace. 8 The evaluation of occupational stress effects on salivary secretion of cortisol has been presenting inconclusive results, although many studies show higher activation of the HHA axis during workdays, when compared to weekends, in different kinds of workforce. [9][10][11][12][13][14][15] In addition, low cortisol levels upon awakening and daytime cortisol decrease have been considered predictors of fatigue, burnout and vital exhaustion.…”
Section: Introductionmentioning
confidence: 99%