Salivary Cortisol and Metabolic Syndrome Component’s Association

Abstract

Background:Actually the lifestyle exposes the population to several risk factors related to alimentary habits and less physical activity that contributes to chronic diseases appearance worldwide. Aim:To analyze the association between salivary cortisol and the components of metabolic syndrome. Methods:This is a cross-sectional study. As part of it, 28 individuals aged 30-59 years presenting three or more of the following findings: CA: ≥88 cm for women and ≥102 cm for men; SBP>130 mmHg and DBP>85 mmHg; GL>100 mg/dl; TG>150 mg/dl; HDL<40 mg/dl for men and <50 mg/dl for women. Was performed analysis of salivary cortisol (by radioimmunoassay) from 25 salivary samples collected throughout the day, for evaluating changes in the circadian rhythm of this hormone (8AM, noon and 8PM). Results:28 evaluated individuals had a mean age of 51.9±7.5 years, mostly women (64.3%) and a mean of BMI 33.6±3.2 kg/m². The cortisol level from the 8AM averaged 18.7±4.8 ng/dlL. Individuals with FPG>110mg/dl, have significantly lower average levels of cortisol than ones with FPG <110 (12.8±5,2 vs. 17.3±4.2). Significant correlations were HOMA vs. WC (r=0,465; p˂0,005) and TG (r=0,473; p˂0,005), WC vs. FG (r=0,446; p˂0,005) and BMI (r=0,730; p˂0.0001); TG vs. HDL (r=0,441 p˂0,005) and FG (r=0,440; p˂0,005). Conclusion:Morning salivary cortisol in subjects with chronically elevated blood glucose can represent a downregulation of the hypothalamic-pituitary adrenal axis. This is an important finding not yet well investigated.

Activities of the hypothalamo‐pituitary‐adrenal axis and autonomic nervous system following a strong earthquake

“…Salivary cortisol levels measured in the current study (17.4 and 15.3 ng/mL) appeared to be within the normal mean range but were slightly higher than Garbellotto et al (2018;10.2-16.7 ng/mL) and Dalilirad et al (2020; 0.5−15 ng/mL). It seems from the current study that salivary cortisol levels were slightly higher in the week 1 compared to the week 6 although the both measurements (week 1 and week 6) were on the higher side of the range.…”

Evidence for disruption of diurnal salivary cortisol rhythm in childhood obesity: relationships with anthropometry, puberty and physical activity

“…Cortisol is a primary product of the hypothalamic-pituitary-adrenal (HPA) axis and acts as the terminal effector of this axis on other systems [ 5 ]. In both human and animal models, cortisol has been causally demonstrated to promote fat accumulation and weight gain as well as glucose homeostasis and lipid metabolism [ 6 , 7 ]. Considering that the production, secretion and abundance of cortisol are regulated in a robust time-of-day-dependent manner [ 8 ], the diurnal cortisol rhythm is a good indicator for comprehensive evaluation of HPA axis activity.…”

Alveolar Bone Pattern and Salivary Leptin Levels Among Premenopausal Obese Women

“…As previously observed, patients with elevated fat mass, regardless of body weight, had high risk of osteopenia, osteoporosis, and non-vertebral fractures 9 . Postmenopausal osteoporosis is closely associated with estrogen deficiency 10 , and it includes periodontal manifestations, such as alveolar bone resorption, clinical attachment loss and tooth loss 11 .…”

“…The radiographs were classified according to the mandibular cortical index (MCI) 17 , considering a qualitative classification of the endosteal margin of the mandibular cortex as follows: C1 - normal; C2 - osteopenia; and C3 - osteoporosis. Patients were classified according to the WHO criteria 10 , i.e., a t-score ranging between -1 and -2.5 standard deviation for osteopenia; and -2.5 standard deviation below the bone mass peak for osteoporosis. When discrepancies in the bone densitometry of spine and femur were verified, the worst classification was considered.…”