Salivary Clear Cell Carcinoma Clinicopathologic Characteristics and Outcomes: A Population-Based Analysis

Abstract

Background: Salivary clear cell carcinoma is an uncommon, low-grade malignancy for which limited data describing predictive clinicopathologic factors and treatment outcomes exist because of rarity. Methods: The authors queried the Surveillance, Epidemiology, and End Results database from 1982 to 2014. Multivariate Cox and Kaplan-Meier analyses were performed to determine disease-specific survival (DSS) and predictive clinicopathologic factors. Results: One hundred ninety-eight patients with salivary clear cell carcinoma were included. Overall incidence was 0.011 per 100 000 individuals, with no significant annual percentage change across years (−0.93%, P = .632). Five-, 10-, and 20-year DSS rates were 81.3% (n = 117), 69.6% (n = 94), and 55.3% (n = 68), respectively. Men (hazard ratio, 4.74; P = .0087) and patients with regional (hazard ratio, 5.59; P = .018) or distant (hazard ratio, 8.9; P = .01) metastases carried a worse prognosis. Five-year DSS was greater in patients with localized disease (96.36%, P < .0001) than those with regional or distant metastases. Treatment with surgery alone had better 10-year DSS (86.3%) compared with treatment with combination radiation and surgery (57.6%) or radiation monotherapy (18.75%, P < .0001). Conclusions: Salivary clear cell carcinoma carries an overall good prognosis. Patients with localized disease and those treated with surgery alone have more favorable prognoses. Male patients and those with regional or distant metastatic disease at time of presentation carry a worse prognosis. Level of Evidence: N/A

Salivary gland hyalinizing clear‐cell carcinoma with cutaneous metastasis: A rare and deceptive tumor

“…Most CCCs present as palate or tongue base masses 2 and are thought to arise from minor salivary glands 1 . While a broad age range has been described, most CCCs are reported in patients >60 years with a nearly equal sex distribution 1 .…”

“…Typically, CCC demonstrates a low‐grade morphology and a favorable course based on a few small case series 1 . However, it has become increasingly recognized that aggressive cases do occur, with one larger study finding lymph node positivity and distant metastasis rates of up to 14% and 3.3% of cases, respectively 2,3 . Herein, we report a CCC with an aggressive clinical course and ensuing cutaneous metastasis.…”

“…1 However, it has become increasingly recognized that aggressive cases do occur, with one larger study finding lymph node positivity and distant metastasis rates of up to 14% and 3.3% of cases, respectively. 2,3 Herein, we report a CCC with an aggressive clinical course and ensuing cutaneous metastasis. To our knowledge, this represents the first cutaneous metastasis of CCC.…”

“…[1][2][3] There has been a reported incidence of 0.011 per 100 000 and it accounts for approximately <5% of all salivary gland cancers. 2 Most CCCs harbor an EWSR1-ATF1 fusion, which is helpful diagnostically. [4][5][6] Typically, CCC demonstrates a low-grade morphology and a favorable course based on a few small case series.…”

“…Salivary gland clear‐cell carcinoma (CCC), also known as hyalinizing clear‐cell carcinoma, is a rare malignant tumor of salivary gland origin 1‐3 . There has been a reported incidence of 0.011 per 100 000 and it accounts for approximately <5% of all salivary gland cancers 2 . Most CCCs harbor an EWSR1‐ATF1 fusion, which is helpful diagnostically 4‐6 .…”