Salivary Chromogranin A (CgA) Response to the Noradrenaline Transporter Blocker Atomoxetine in Dogs

Kooriyama, Takanori; Mukhopadhyay, Abhijit; Moore, George E.; Ogata, Niwako

doi:10.3390/ani11102844

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…In women, high salivary CgA correlates with negative premenstrual mood disturbance (Matsumoto et al, 2012). CgA is previously validated as a stress marker in dogs (Kooriyama et al, 2021) and pigs (Escribano et al, 2013). High concentrations of CgA are found in sows suffering from postpartum dysgalactia syndrome (PPDS) (Kaiser et al, 2018), a disease that seems to have consequences for reproduction (Peltoniemi et al, 2016).…”

Section: The Role Of the Sympatho -Adrenomedull Ary Sys Tem (Sam)mentioning

confidence: 99%

Pathogenesis of the crosstalk between reproductive function and stress in animals—part 1: Hypothalamo–pituitary–adrenal axis, sympatho‐adrenomedullary system and kisspeptin

Kaiser,

Jaillardon

2023

Reprod Domestic Animals

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Stress is defined as a disruption of the body homeostasis in response to modest as well as perceived challenge. Two main physiological routes, the hypothalamic–pituitary–adrenal system (HPA) and the sympatho‐adrenomedullary system (SAM), aim to maintain or restore homeostasis by mutual interaction. SAM is quickly‐reacting as it primarily works through the nervous system—the sympathetic nervous system. In response to stress, signals are sent to activate the adrenal medulla which releases catecholamines (primarily adrenaline and norepinephrine). The catecholamines have a momentary effect on the body's organs that are prepared for a fight situation. At the same time, the stressor activates the HPA axis by signals from the brain causing secretion of the pituitary hormone adrenocorticotropic hormone (ACTH). ACTH acts on the adrenal cortex, which secretes glucocorticoids, including cortisol. Since HPA primarily works through hormones, the system is slightly slower than SAM and gives rise to a metabolic effect. While short‐term stress response is an adaptive and beneficial process, chronic or excessive stress can lead to a range of negative health outcomes including reproductive disorders and infertility. Several mechanisms have been proposed to explain the link between stress and reproduction. This includes in particular kisspeptin, which is closely related to reproduction, as it is a powerful stimulator of the Hypothalamic–pituitary–gonadal (HPG) system. The present review, through current knowledge in various male and female species, deals with the role of the SAM and the HPA, including the major action of kisspeptin and glucocorticoids that trigger the consequences of psychological or physiological stress on reproductive function.

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Section: The Role Of the Sympatho -Adrenomedull Ary Sys Tem (Sam)mentioning

confidence: 99%

Pathogenesis of the crosstalk between reproductive function and stress in animals—part 1: Hypothalamo–pituitary–adrenal axis, sympatho‐adrenomedullary system and kisspeptin

Kaiser,

Jaillardon

2023

Reprod Domestic Animals

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“… 22 Among depressed patients, the levels of awakening salivary CgA significantly increased. 23 Previous studies mostly focused on salivary CgA level, 24 , 25 , 26 however, few focused on plasma CgA level, while plasma CgA are regarded as a valuable predictor of cardiovascular diseases. Saliva is convenient to retain samples.…”

Section: Introductionmentioning

confidence: 99%

Associations between chronic work stress and plasma chromogranin A/catestatin among healthy workers

Liu

Dang

Liu

et al. 2022

Journal of Occupational Health

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Objectives Plasma chromogranin A (CgA) may play a critical role on linking work stress to health outcomes. The aim of our study was to investigate the associations between work stress and plasma CgA levels in healthy workers without chronic diseases. Methods The study included 260 healthy workers from EHOP study. Work stressors were assessed by the Chinese version of the 23‐item ERI‐Q questionnaire. Plasma CgA and catestatin levels were measured by ELISA kits. The demographic characteristics were collected from medical records. Results Among the final 260 subjects including 173 males (66.5%) and 87 females (33.5%), the average age was 37.6 ± 10.6 years old. Effort, overcommitment, and ERI were positively associated with plasma CgA level, respectively (r = 0.267, 0.319, and 0.304, all p < .001), while reward was negatively associated with CgA level (r = −0.237, p < .001). The workers with high effort, overcommitment, or ERI had significantly higher plasma CgA levels, while the workers with high rewards had significantly lower plasma CgA levels. The workers with both high overcommitment and high ERI had highest plasma CgA levels. In the linear regression analysis, after adjustment for confounders, effort, overcommitment, and ERI were respectively positively related to plasma CgA, while reward negatively related to plasma CgA. The associations between work stress and plasma catestatin was not significant. The ratio of CgA and catestatin was associated with work stress. Conclusions Work stress is associated with plasma CgA which may be play a crucial role on the pathway from chronic work stress to cardiovascular diseases.

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Salivary Chromogranin A (CgA) Response to the Noradrenaline Transporter Blocker Atomoxetine in Dogs

Cited by 2 publications

References 33 publications

Pathogenesis of the crosstalk between reproductive function and stress in animals—part 1: Hypothalamo–pituitary–adrenal axis, sympatho‐adrenomedullary system and kisspeptin

Pathogenesis of the crosstalk between reproductive function and stress in animals—part 1: Hypothalamo–pituitary–adrenal axis, sympatho‐adrenomedullary system and kisspeptin

Associations between chronic work stress and plasma chromogranin A/catestatin among healthy workers

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