Salivary Chromogranin a as an Index of Psychosomatic Stress Response

Nakane, Hideo; Asami, Osamu; Yamada, Yukio; Harada, Takeshi; Matsui, Nobuo; Kanno, Tomio; Yanaihara, Noboru

doi:10.2220/biomedres.19.401

Cited by 159 publications

(169 citation statements)

References 0 publications

Supporting

Mentioning

159

Contrasting

Unclassified

Order By: Relevance

“…34 The CgA concentration was corrected by the total protein concentration of saliva. 12,16,17 Basal CgA concentration differs from individual to individual, and the values were not normally distributed as in previous studies. 17,29 Referring to earlier investigations, 18,35,36 therefore, the values for CgA concentration before the aroma inhalation were standardized to 100%.…”

Section: Determination Of Salivary Cgamentioning

confidence: 82%

“…11 Salivary CgA, thus, has been proposed as a surrogate marker of sympathetic nervous system activity. 12 A series of studies has shown that compared with salivary cortisol, salivary CgA increases more rapidly and more sensitively to psychological stressors induced by activities such as public speaking, 12 word-processing and arithmetic tasks, 13,14 academic examinations, 15 and venipuncture in hospitalized children. 16 A recent finding from the author's laboratory further demonstrated that salivary CgA levels in the late-luteal phase significantly increased among women with severe premenstrual emotional symptoms, while salivary cortisol showed no menstrual-cyclic changes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Olfactory Stimulation from the Fragrance of the Japanese Citrus Fruit Yuzu (Citrus junos Sieb. ex Tanaka) on Mood States and Salivary Chromogranin A as an Endocrinologic Stress Marker

Matsumoto

Asakura²,

Hayashi

2014

The Journal of Alternative and Complementary Medicine

View full text Add to dashboard Cite

Objective: This study investigated the soothing effects of fragrance from yuzu, a Japanese citrus fruit (Citrus junos Sieb. ex Tanaka), with salivary chromogranin A (CgA) used as an endocrinologic stress marker reflecting sympathetic nervous system activity. Methods: Twenty healthy women (mean age, 20.5 -0.1 years) participated in a randomized, controlled, crossover study. Participants were examined on two separate occasions-once using the yuzu scent and once using unscented water as a control-in the follicular phase. This experiment measured salivary CgA and the Profile of Mood States (POMS) as a psychological index before and after the aromatic stimulation. Results: Ten-minute inhalation of the yuzu scent significantly decreased salivary CgA. At 30 minutes after the inhalation period, the salivary CgA level further decreased. In addition, POMS revealed that inhalation of the aromatic yuzu oil significantly decreased total mood disturbance, a global measure of affective state, as well as four subscores of emotional symptoms (tension-anxiety, depression-dejection, anger-hostility, and confusion), as long as 30 minutes after the olfactory stimulation. Conclusions: Yuzu's aromatic effects may alleviate negative emotional stress, which, at least in part, would contribute to the suppression of sympathetic nervous system activity.

show abstract

Section: Determination Of Salivary Cgamentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Effects of Olfactory Stimulation from the Fragrance of the Japanese Citrus Fruit Yuzu (Citrus junos Sieb. ex Tanaka) on Mood States and Salivary Chromogranin A as an Endocrinologic Stress Marker

Matsumoto

Asakura²,

Hayashi

2014

The Journal of Alternative and Complementary Medicine

View full text Add to dashboard Cite

show abstract

“…The effect was comparable in men and women, and therefore summarized results for all subjects are shown. State part of the STAI inventory (lower part alomo-pituitary-adrenal hormone cortisol and the sympathetic system marker, chromogranin-A (13,21,22,38), were used as objective measures of stress response. The standard Japanese version of the State Trait Anxiety Inventory (STAI, 36) served as a subjective measure of stress and anxiety perception.…”

Section: Resultsmentioning

confidence: 99%

Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans

et al. 2007

View full text Add to dashboard Cite

Dietary supplementation with an essential amino acid L-lysine has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. A combination of L-lysine and L-arginine has been documented to normalize hormonal stress responses in humans with high trait anxiety. The present study was carried out in one hundred eight healthy Japanese adults. The aim of study was to find out whether a week-long oral treatment with L-lysine (2.64 g per day) and L-arginine (2.64 g per day) reduces trait and stress-induced state anxiety and basal levels of stress hormones. We confirmed that, without regard to gender, the amino acid treatment significantly reduced both trait anxiety and state anxiety induced by cognitive stress battery. In addition, we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects. These results of this double-blind, placebo controlled and randomized study confirm the previous findings in humans and animals and point to a combination of L-lysine and L-arginine as a potentially useful dietary intervention in otherwise healthy humans with high subjective levels of mental stress and anxiety.

show abstract

“…In vitro experiments have also demonstrated that CgA exhibits antifungal and antibacterial properties 17,18) . Salivary CgA concentration increases rapidly under psychosomatic stress 19) , although the response of CgA to exercise is yet to be determined. Exercise is a prototype of physical stressor that induces a host of hormonal, metabolic, cardiovascular and immunological change.…”

Section: ⅰ．Introductionmentioning

confidence: 99%

Effects of Acute Prolonged Strenuous Exercise on the Salivary Stress Markers and Inflammatory Cytokines

Usui

Yoshikawa

Ueda

et al. 2011

Jpn. J. Phys. Fitness Sports Med.

View full text Add to dashboard Cite

The aim of the present study was to examine whether amount of oral cortisol, immunoglobulin A (IgA), chromogranin A (CgA) and inflammatory cytokines, might be affected by prolonged strenuous exercise. Ten young male volunteers either exercised on recumbent ergometer at 75 % V 4 O 2 max for 60 min (exercise session) or sat quietly (resting session). Saliva samples were obtained at 60 min intervals during sessions for measurements of salivary stress markers (cortisol, IgA and CgA), salivary inflammatory cytokines, such as interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and osmolality. Saliva flow rate was decreased and saliva osmolality was increased during the 60-min exercise. Saliva cortisol and CgA concentrations and secretion rates were increased during and after the exercise, whereas saliva IgA concentration and secretion rates were decreased after the exercise. Salivary inflammatory cytokines was increased during and after the exercise. The present findings suggested a single bout of prolonged strenuous exercise caused a transient increase in the salivary cortisol, CgA and inflammatory cytokines levels, whereas salivary IgA concentration and secretion rates were decreased after the exercise. Further studies, however, are needed to delineate whether or not salivary stress markers and inflammatory cytokines may be used as biological markers to determine the host responses to acute prolonged strenuous exercise.(Jpn. J. Phys. Fitness Sports Med., 60（ 3 ）: 295-304 (2011))

show abstract

Salivary Chromogranin a as an Index of Psychosomatic Stress Response

Cited by 159 publications

References 0 publications

Effects of Olfactory Stimulation from the Fragrance of the Japanese Citrus Fruit Yuzu (Citrus junos Sieb. ex Tanaka) on Mood States and Salivary Chromogranin A as an Endocrinologic Stress Marker

Effects of Olfactory Stimulation from the Fragrance of the Japanese Citrus Fruit Yuzu (Citrus junos Sieb. ex Tanaka) on Mood States and Salivary Chromogranin A as an Endocrinologic Stress Marker

Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans

Effects of Acute Prolonged Strenuous Exercise on the Salivary Stress Markers and Inflammatory Cytokines

Contact Info

Product

Resources

About