Salivary catalase and peroxidase values in normal subjects and in persons with periodontal disease

Kraus, Frederick W.; Perry, William I.; Nickerson, John F.

doi:10.1016/0030-4220(58)90228-7

Cited by 25 publications

(13 citation statements)

References 6 publications

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“…The present results explain why earlier studies about the possible correlation be tween free salivary peroxidase activity and oral health have given controversial results [Kraus et al, 1958;Wolfe and Turner, 1957;Kato and Nagatsu, 1967;Tenovuo, 1976], The free salivary peroxidase activity is, according to recent studies [Pruitt and Adamson, 1977;Tenovuo, 1979], of minor importance compared with the bound activ ity. Therefore, the correlations between apatite-or cell-bound activity, OSCN" for mation and the clinical condition are much more informative.…”

Section: Discussionsupporting

confidence: 69%

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Peroxidase-Catalyzed Hypothiocyanite Production in Human Salivary Sediment in Relation to Oral Health

Tenovuo¹,

Anttonen²

1980

Caries Res

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The formation of the bacterial inhibitor, hypothiocyanite (OSCN^––) ion, by human salivary sediment was studied in relation to oral health. Persons with good oral health produced significantly more OSCN^–– ions than those with poor oral status. However, no relation in the amount of SCN^–– ions and the activity of free or cell-bound peroxidase to oral health was found. This suggests that the difference in OSCN^–– formation results from differences in endogenous H₂O₂ production. It is not sure that increased OSCN^–– production leads to better oral health, possibly vice versa, but anyway there is a clear positive correlation. About 80% of oral total peroxidase activity was found to be bound to plaque bacteria.

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Section: Discussionsupporting

confidence: 69%

“…However, the present results showed no difference in per oxidase activity; catalase was not assayed. Kraus et al [1958] observed increased cata lase activities in persons with severe perio dontitis, possibly because of bacterial prolif eration. This may lead to increased decom position of HoO._> in persons with poor oral health.…”

Section: Discussionmentioning

confidence: 97%

Peroxidase-Catalyzed Hypothiocyanite Production in Human Salivary Sediment in Relation to Oral Health

Tenovuo¹,

Anttonen²

1980

Caries Res

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“…10 Some of the advantages of H 2 O 2 include easy accessibility, low cost, and longtrack record in dentistry. 18,19 However its disadvantages include its potential for toxicity under routine use by dental professionals, 18 gastric and colon disturbances, 20 inactivation in the mouth due to host catalase activity in the saliva, 21 and absence of any clinical or in vitro evidence for viricidal activity against SARS-CoV-2. 12 The purpose of this study was to compare in vitro inactivation of SARS CoV-2 with hydrogen peroxide (H 2 O 2 ) and povidone-iodine (PVP-I) oral antiseptic rinses at clinically recommended concentrations and clinically convenient timescales.…”

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confidence: 99%

Comparison of In Vitro Inactivation of SARS CoV‐2 with Hydrogen Peroxide and Povidone‐Iodine Oral Antiseptic Rinses

Bidra

Pelletier

Westover

et al. 2020

Journal of Prosthodontics

152

167

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Purpose To evaluate the in vitro inactivation of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) with hydrogen peroxide (H2O2) and povidone‐iodine (PVP‐I) oral antiseptic rinses at clinically recommended concentrations and contact times. Materials and Methods SARS‐CoV‐2, USA‐WA1/2020 strain virus stock was prepared prior to testing by growing in Vero 76 cells. The culture media for prepared virus stock was minimum essential medium (MEM) with 2% fetal bovine serum (FBS) and 50 µg/mL gentamicin. Test compounds consisting of PVP‐I oral rinse solutions and H2O2 aqueous solutions were mixed directly with the virus solution so that the final concentration was 50% of the test compound and 50% of the virus solution. Thus PVP‐I was tested at concentrations of 0.5%, 1.25%, and 1.5%, and H2O2 was tested at 3% and 1.5% concentrations to represent clinically recommended concentrations. Ethanol and water were evaluated in parallel as standard positive and negative controls. All samples were tested at contact periods of 15 seconds and 30 seconds. Surviving virus from each sample was then quantified by standard end‐point dilution assay and the log reduction value of each compound compared to the negative control was calculated. Results After the 15‐second and 30‐second contact times, PVP‐I oral antiseptic rinse at all 3 concentrations of 0.5%, 1.25%, and 1.5% completely inactivated SARS‐CoV‐2. The H2O2 solutions at concentrations of 1.5% and 3.0% showed minimal viricidal activity after 15 seconds and 30 seconds of contact time. Conclusions SARS‐CoV‐2 virus was completely inactivated by PVP‐I oral antiseptic rinse in vitro, at the lowest concentration of 0.5 % and at the lowest contact time of 15 seconds. Hydrogen peroxide at the recommended oral rinse concentrations of 1.5% and 3.0% was minimally effective as a viricidal agent after contact times as long as 30 seconds. Therefore, preprocedural rinsing with diluted PVP‐I in the range of 0.5% to 1.5% may be preferred over hydrogen peroxide during the COVID‐19 pandemic.

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“…III, IV, V, VII and VIII (table 3) whose mean percentages of salivary bacteria producing peroxide were known to be high. The catalase activities in the saliva of all 13 subjects were determined and found to be within the normal range (Kraus et al, 1957). If any ether extractable hydrogen peroxide was present in these samples, it was below the detectable threshold of 1 ,g/ml.…”

Section: Resultsmentioning

confidence: 99%

Peroxide and Peroxidogenic Bacteria in Human Saliva

et al. 1957

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Salivary catalase and peroxidase values in normal subjects and in persons with periodontal disease

Cited by 25 publications

References 6 publications

Peroxidase-Catalyzed Hypothiocyanite Production in Human Salivary Sediment in Relation to Oral Health

Peroxidase-Catalyzed Hypothiocyanite Production in Human Salivary Sediment in Relation to Oral Health

Comparison of In Vitro Inactivation of SARS CoV‐2 with Hydrogen Peroxide and Povidone‐Iodine Oral Antiseptic Rinses

Peroxide and Peroxidogenic Bacteria in Human Saliva

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