Salivary carbonic anhydrase isoenzyme VI

Abstract

The carbonic anhydrases (CAs) participate in the maintenance of pH homeostasis in various tissues and biological fluids of the human body by catalysing the reversible reaction

Carbonic Anhydrase IX Is Highly Expressed in Hereditary Nonpolyposis Colorectal Cancer

“…Tumor-associated CAs may participate in oncogenesis by acidifying the extracellular milieu adjacent to cancer cells. This acidification would create a microenvironment within the tumor that would be conducive to cancer growth and spread (18,19). Although the exact mechanisms are largely unknown, acidification has been linked to various events of tumor progression such as defective intercellular adhesion, increased invasion, and up-regulation of growth factors and matrix metalloproteinases.…”

Salivary carbonic anhydrase, pH and phosphate buffer concentrations as potential biomarkers of caries risk in children

“…[16] CA VI is a secretory isoenzyme secreted into the saliva by the serous acinar cells of the human parotid and submandibular glands. [17] Salivary CA VI is the first salivary protein reported to be associated with the occurrence of caries in individuals. [17] CA VI is believed to provide a greater buffering capacity to saliva by penetrating dental Biofilm and facilitating acid neutralization by salivary bicarbonate.…”

Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules

“…The affinity gel was washed with 25 mM Tris-HCl/22 mM Na 2 SO 4 (pH 8.7). The human carbonic anhydrase (hCA VI) isozyme was eluted with 0.25 M H 2 NSO 3 H/25 mM Na 2 HPO 4 (pH = 6.7 19,20 ).…”