Salivary C-Reactive Protein in Hashimoto's Thyroiditis and Subacute Thyroiditis

Rao, Nivedita L.; Sudhaharan, Sukanya; Upadhyaya, Krishnaraj; M, Prasad R.; Lobo, Eric C.; Kedilaya, H. P.; Prasad, Ganesh

doi:10.4061/2010/514659

Cited by 20 publications

(14 citation statements)

References 22 publications

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“…Methods for saliva collection from primates have been used in free‐ranging settings (Higham et al, ), and similar or adapted methods are probably feasible for numerous (though clearly not all) primate species in free‐ranging populations. In saliva, many native analytes can be measured, including sympathetic axis correlates such as alpha‐amylase (e.g., rhesus macaques, Higham et al, ; bonobos, Beringer et al, ), haptoglobin (e.g., pigs, Gómez‐Laguna et al, ), and CRP (e.g., humans, Rao et al, ).…”

Section: Discussionmentioning

confidence: 99%

Evaluating noninvasive markers of nonhuman primate immune activation and inflammation

Higham

Kraus

Stahl–Hennig∥

et al. 2015

American J Phys Anthropol

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Evaluating noninvasive markers of nonhuman primate immune activation and inflammation.http://researchonline.ljmu.ac.uk/3193/ Article LJMU has developed LJMU Research Online for users to access the research output of the University more effectively. Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Users may download and/or print one copy of any article(s) in LJMU Research Online to facilitate their private study or for non-commercial research. You may not engage in further distribution of the material or use it for any profit-making activities or any commercial gain.The version presented here may differ from the published version or from the version of the record. Please see the repository URL above for details on accessing the published version and note that access may require a subscription.

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Section: Discussionmentioning

confidence: 99%

Evaluating noninvasive markers of nonhuman primate immune activation and inflammation

Higham

Kraus

Stahl–Hennig∥

et al. 2015

American J Phys Anthropol

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“…It is characterized by diff use lymphocytic infi ltration of the thyroid gland. Despite studies on autoimmune infl ammation, the pathogenesis of CAT still remains unclear (Rao et al 2010;Poplawska-Kita et al 2015).…”

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confidence: 99%

Elevated neutrophil-lymphocyte ratio in patients with euthyroid chronic autoimmune thyreotidis

Keskin

Kaya

Çadırcı

et al. 2016

Endocrine Regulations

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Objective. Th e neutrophil-lymphocyte ratio (NLR), determined from peripheral blood, is accepted as an available and practical indicator of the systemic infl ammation. In this study, we aimed to determine whether the NLR was higher in euthyroid chronic autoimmune thyreotidis (CAT) patients compared to a healthy control group.Methods. A total of 112 patients were enrolled in this study, including 59 patients with euthyroid CAT on any form of therapy and 53 healthy controls. Th e CAT patients were similar in age to the healthy control group (mean 33.9±12.8 years versus 30.2±12.4 years, p=0.10). Measurements were available for the white blood cells (WBC), neutrophils, lymphocytes, platelets, C-reactive protein (CRP), thyroid peroxidase immune antibody (anti-TPO), and anti-thyroglobulin immune antibody (anti-TG). Th e NLR and platelet-lymphocyte ratio (PLR) were calculated. Diff erences between the CAT and control groups were tested using the student's t-test and the correlations were determined using Pearson's correlation coeffi cients.Results. Th ere were no diff erences between the CAT and control groups for WBCs (7.9±0.3 and 7.4±0.2, respectively; p=0.1) or neutrophils (5.5±0.3 and 5.4±1.1; p=0.9), but lymphocytes were higher in the CAT group (3.1±0.5 vs. 2.04±0.1; p=0.05) as was the NLR (4.0±0.7 vs. 2.0±0.1; p=0.01). Th e NLR was positively correlated with CRP (r=0.6, p<0.001), anti-TPO (r=0.3, p<0.001), anti-TG (r=0.3, p=0.006), WBCs (r=0.4, p<0.001), and the PLR (r=0.73, p<0.001). Th e PLR was also higher in the CAT than the control group (p=0.02).Conclusions. In this study, we found that NLR values were higher in euthyroid CAT patients than in a healthy control group and that NLR correlated with autoantibodies used to diagnose the disease.

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“…The study of salivary CRP levels in such two groups with thyrotoxicosis of different etiology may give new insight in this aspect, as indicated by other workers. [12] However we did not have an opportunity to study the same in our patients. A lot of information which is now available suggests that mild rise in serum CRP levels in CAT patients suggest ongoing low grade inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…[6] Salivary CRP also rises significantly in SAT and hence has been proposed as a helpful biomarker in differentiating such an inflammatory thyroid disorder from others. [12] Thus it has been observed that rise in CRP in blood or body secretion is most striking in SAT amongst all sorts of thyroid disorders. In various other fields of medicine, serum CRP has evolved as a sensitive marker for underlying inflammatory pathology, response to therapy and prognosis of the disease process.…”

Section: Introductionmentioning

confidence: 99%

Significant role of serum CRP in differentiating inflammatory from non-inflammatory causes of thyrotoxicosis

Baruah

Bhattacharya

2012

Indian J Endocr Metab

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Background:C-reactive protein (CRP), which is a marker of inflammation, has not been widely studied in inflammatory thyroid disorders particularly in sub-acute thyroiditis (SAT).Aim:This study was aimed to find the significance of CRP level rise in patients with SAT and compare that to the rise in erythrocyte sedimentation rate (ESR), a gold standard laboratory parameter in establishing the diagnosis of SAT.Materials and Methods:Serum CRP levels were measured at initial presentation in 28 subjects with SAT(12 male, 16 female, age (Mean +SD) 37.96 ±8.5 years),and 19 patients with Graves’ disease (2 male, 17 female, age [Mean +SD] 36.8 ±16.5 years) as controls. Erythrocyte sedimentation rate (ESR) was measured in all 28 patients with SAT by Westergrens’ method. Either Tc99 nucleotide thyroid scan or high resolution ultrasonography (HR-USG) was performed to differentiate SAT from Graves’ disease.Fine needle aspiration cytology (FNAC) of thyroid was performed selected patients.Results:Serum CRP level was high in 61% of SAT patients but in none of the Graves′patients. Mean (SEM) (90%CI) serum CRP level (mg/L) was also significantly higher (P <0.0004) in the SAT group [27.55 (5.76) (15.72-39.38)], than in the Graves’ group [4.09 (0.12) (3.81-4.36)]. The sensitivity of serum CRP was 73.33%, specificity 53.85%, positive predictive value (PPV) 64.71%, and negative predictive value (NPV) 63.64% as compared to the sensitivity (53.57%), specificity (15.38%), PPV (57.69 %), and NPV (13.33%) of ESR.Conclusion:There is significantly higher rise in serum CRP level in patients with SAT is compared to patients with Graves’ disease. It correlates well with the rise in ESR. Such findings of this pilot study highlight the scope of using serum CRP as a diagnostic marker of SAT specially in situations when it may be confused with Graves’ disease, another common cause of thyrotoxicosis. It is logical to carry out studies to find a particular cut-off for serum CRP which can serve as an objective parameter for grading the inflammation in patients with SAT.

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Salivary C-Reactive Protein in Hashimoto's Thyroiditis and Subacute Thyroiditis

Cited by 20 publications

References 22 publications

Evaluating noninvasive markers of nonhuman primate immune activation and inflammation

Evaluating noninvasive markers of nonhuman primate immune activation and inflammation

Elevated neutrophil-lymphocyte ratio in patients with euthyroid chronic autoimmune thyreotidis

Significant role of serum CRP in differentiating inflammatory from non-inflammatory causes of thyrotoxicosis

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