Salivary C-reactive protein—a possible predictor of serum levels in pediatric acute respiratory illness

Gofin, Yoel; Fanous, Eliana; Pasternak, Yael; Prokocimer, Zafnat; Zagoory‐Sharon, Orna; Feldman, Ruth; Codick, Gabriel; Waisbourd‐Zinman, Orith; Fried, Sophia; Livni, Gilat

doi:10.1007/s00431-021-04047-6

Cited by 6 publications

(4 citation statements)

References 48 publications

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“…CRP, an acute-phase response protein synthesized by the liver in response to elevated cytokine levels, was studied as a sensitive marker of inflammatory conditions [ 35 ]. In our previous study, we found that salivary CRP levels were positively correlated with serum CRP levels, which is supported by previous reports [ 14 , 30 , 36 ]. However, in this preliminary study, we failed to find that salivary CRP was helpful in distinguishing Streptococcus pneumoniae from influenza A virus-related CAPs.…”

Section: Discussionsupporting

confidence: 91%

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Salivary Biomarkers to Differentiate between Streptococcus pneumoniae and Influenza A Virus-Related Pneumonia in Children

et al. 2023

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Community-acquired pneumonia (CAP) is common among children and can be fatal in certain conditions. In children, CAP can be caused by viral or bacterial infections. Identification of pathogens can help select appropriate therapeutic strategies. Salivary analysis may be a potential diagnostic tool because it is noninvasive, patient-friendly, and easy to perform in children. A prospective study was conducted in children with pneumonia admitted to a hospital. Salivary samples from patients with definite Streptococcus pneumoniae and influenza A strains were used for gel-free (isobaric tag for relative and absolute quantitation (iTRAQ)) proteomics. No statistically significant difference was detected in salivary CRP levels between Streptococcus pneumoniae and influenza A pneumonia in children. Several potential salivary biomarkers were identified using gel-free iTRAQ proteomics to differentiate pneumonia from Streptococcus pneumoniae or influenza A virus infections in pediatric patients. ELISA validated that Streptococcus pneumoniae group has a higher abundance of salivary alpha 1-antichymotrypsin than those in the influenza A group. Whether these salivary biomarkers can be used to distinguish other bacteria from viral pneumonia requires further verification.

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Section: Discussionsupporting

confidence: 91%

“…Recently, saliva gradually gained recognition in specific fields as a diagnostic alternative to blood collection [ 30 , 31 , 32 , 33 , 34 ]. Because saliva collection is simple, noninvasive, inexpensive, and requires relatively simple instructions, it is particularly suitable for use in pediatric patients.…”

Section: Discussionmentioning

confidence: 99%

Salivary Biomarkers to Differentiate between Streptococcus pneumoniae and Influenza A Virus-Related Pneumonia in Children

et al. 2023

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“…Gofin et al ( 137 ) showed that in a sample of 104 children aged between 2 and 18 diagnosed with acute respiratory illness, sCRP level was highly specific for predicting high pCRP level. Therefore, sCRP is a potential alternative for pCRP in acute pediatric settings.…”

Section: Resultsmentioning

confidence: 99%

The Role of Salivary C-Reactive Protein in Systemic and Oral Disorders: A Systematic Review

Babaei

Rezaei

Khadem

et al. 2022

Med. J. Islam. Republ. Iran

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“…90 An eNose in an incubator could continuously analyze exhaled air and can be an addition to early detection of LONS. 91,92 ANTIBIOTIC THERAPY Empirical antibiotic therapy During the initial treatment phase, if sepsis is suspected, it is of utmost importance to assure efficacy of treatment. 10,93 Usually, empirical antibiotic therapy is initiated covering the most common causative microorganisms.…”

Section: Serum Biomarkersmentioning

confidence: 99%

Knowledge gaps in late-onset neonatal sepsis in preterm neonates: a roadmap for future research

et al. 2021

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Late-onset neonatal sepsis (LONS) remains an important threat to the health of preterm neonates in the neonatal intensive care unit. Strategies to optimize care for preterm neonates with LONS are likely to improve survival and long-term neurocognitive outcomes. However, many important questions on how to improve the prevention, early detection, and therapy for LONS in preterm neonates remain unanswered. This review identifies important knowledge gaps in the management of LONS and describe possible methods and technologies that can be used to resolve these knowledge gaps. The availability of computational medicine and hypothesis-free-omics approaches give way to building bedside feedback tools to guide clinicians in personalized management of LONS. Despite advances in technology, implementation in clinical practice is largely lacking although such tools would help clinicians to optimize many aspects of the management of LONS. We outline which steps are needed to get possible research findings implemented on the neonatal intensive care unit and provide a roadmap for future research initiatives.

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Salivary C-reactive protein—a possible predictor of serum levels in pediatric acute respiratory illness

Cited by 6 publications

References 48 publications

Salivary Biomarkers to Differentiate between Streptococcus pneumoniae and Influenza A Virus-Related Pneumonia in Children

Salivary Biomarkers to Differentiate between Streptococcus pneumoniae and Influenza A Virus-Related Pneumonia in Children

The Role of Salivary C-Reactive Protein in Systemic and Oral Disorders: A Systematic Review

Knowledge gaps in late-onset neonatal sepsis in preterm neonates: a roadmap for future research

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