Salivary biomarker for acute appendicitis in children: a pilot study

Yap, Te‐Lu; Fan, Jing; Ho, Meng Fatt; Choo, Candy S C; Ong, Lin Yin; Chen, Yong

doi:10.1007/s00383-020-04645-9

Cited by 12 publications

(29 citation statements)

References 25 publications

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“…The ERAS concept has emerged on this basis (13)(14)(15). ERAS takes the patient as the center, adopts the optimized perioperative treatment, alleviates the stress response caused by surgery, reduces the postoperative complication rate, and reduces the length of hospital stay, thus achieving the aim of rapid recovery (16)(17)(18). ERAS involves a combination of rehabilitation, surgery, anesthesia, nursing, and other disciplines to optimize routine perioperative treatment (19).…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta-analysis of the effects of the perioperative enhanced recovery after surgery concept on the surgical treatment of acute appendicitis in children

Zhang¹,

Liang²,

Chen³

et al. 2021

Transl Pediatr

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Section: Discussionmentioning

confidence: 99%

Systematic review and meta-analysis of the effects of the perioperative enhanced recovery after surgery concept on the surgical treatment of acute appendicitis in children

Zhang¹,

Liang²,

Chen³

et al. 2021

Transl Pediatr

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“…Scores based on clinical, analytical and radiological variables have also been explored [ 4 , 5 ]. On the other hand, new biomarkers have been evaluated prospectively in serum [ 6 ], urine [ 7 ], faeces [ 8 ] and saliva [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of serum pentraxin-3 in pediatric acute appendicitis: a prospective diagnostic validation study

et al. 2022

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Introduction Pediatric acute appendicitis (PAA) is a pathology with a high rate of diagnostic error. The search for new diagnostic tools is justified by the high morbidity and healthcare costs associated with diagnostic error. Methods We designed a prospective study to validate serum pentraxin-3 (PTX3) as a diagnostic tool in PAA. Participants were divided into three groups: (1) patients with no underlying pathology (2) patients with non-surgical abdominal pain and (3) patients with a confirmed diagnosis of PAA. For further analyses, patients in group 3 were divided into complicated or uncomplicated PAA. Quantitative variables were expressed as medians and interquartile ranges and categorical variables as percentages. Quantitative variables were compared using the Kruskal–Wallis test and the Mann–Whitney U test. Diagnostic performance was evaluated with ROC curves. Results This study included 215 patients divided into group 1 (n = 63), group 2 (n = 53) and group 3 (n = 99). Median serum PTX3 values were 2.54 (1.70–2.95) ng/mL, 3.29 (2.19–7.64) ng/mL and 8.94 (6.16–14.05) in groups 1, 2 and 3, respectively (p = 0.001). Patients with complicated PAA showed significantly higher values than patients with uncomplicated PAA (p = 0.04). The AUC (group 2 vs. 3) was 0.77 (95% CI 0.69–0.85) and the best cut-off point was at 7.28 ng/mL, with a sensitivity of 61.3% and a specificity of 73.1%. The AUC (complicated vs. uncomplicated PAA) was 0.65 (95% CI 0.54–0.77) and the best cut-off point was 12.33 ng/mL, with a sensitivity of 51.72% and a specificity of 72.73%. Conclusions The diagnostic ability of serum PTX3 in PAA is only moderate and therefore it cannot be considered a definitive diagnostic test. The discriminatory ability of PTX3 between complicated and uncomplicated PAA is poor. These findings, which contrast with those reported to date, should be validated with future properly designed prospective studies.

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“…However, similar to other markers of inflammation, LRG is not specific to appendicitis as it is also elevated in several other bacterial and inflammatory conditions [21,53,54]. Extending our understanding of LRG in the diagnosis of appendicitis, a recent study investigated the use of salivary LRG to diagnose the condition in children [33]. Compared with LRG in urine samples, salivary LRG demonstrated better diagnostic accuracy with an increased sensitivity value [33].…”

Section: Novel Protein Biomarkersmentioning

confidence: 99%

“…Extending our understanding of LRG in the diagnosis of appendicitis, a recent study investigated the use of salivary LRG to diagnose the condition in children [33]. Compared with LRG in urine samples, salivary LRG demonstrated better diagnostic accuracy with an increased sensitivity value [33]. Though promising, additional research is needed within this field, to confirm the clinical utility of salivary markers for appendicitis.…”

Section: Novel Protein Biomarkersmentioning

confidence: 99%

Novel Molecular Biomarkers and Diagnosis of Acute Appendicitis in Children

et al. 2021

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Reliable and efficient diagnosis of pediatric appendicitis is essential for the establishment of a clinical management plan and improvement of patient outcomes. Current strategies used to diagnose a child presenting with a suspected appendicitis include laboratory studies, clinical scores and diagnostic imaging. Although these modalities work in conjunction with each other, one optimal diagnostic strategy has yet to be agreed upon. The recent introduction of precision medicine techniques such as genomics, transcriptomics, proteomics and metabolomics has increased both the diagnostic sensitivity and specificity of appendicitis. Using these novel strategies, the integration of precision medicine into clinical practice via point-of-care technologies is a plausible future. These technologies would assist in the screening, diagnosis and prognosis of pediatric appendicitis.

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Salivary biomarker for acute appendicitis in children: a pilot study

Cited by 12 publications

References 25 publications

Systematic review and meta-analysis of the effects of the perioperative enhanced recovery after surgery concept on the surgical treatment of acute appendicitis in children

Systematic review and meta-analysis of the effects of the perioperative enhanced recovery after surgery concept on the surgical treatment of acute appendicitis in children

Diagnostic performance of serum pentraxin-3 in pediatric acute appendicitis: a prospective diagnostic validation study

Novel Molecular Biomarkers and Diagnosis of Acute Appendicitis in Children

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