Salivary ATP13A2 is a potential marker of therapy-induced motor complications and is expressed by inclusions in submandibulary glands in Parkinson ́s disease

Fernández-Espejo, Emilio; Gavito, Ana Luisa; Suárez, Juan; Tolosa, Eduardo; Vilas, Dolores; Aldecoa, Ibán; Berenguer, Joan; Córdoba-Fernández, Antonio; Damas-Hermoso, Fátima; Fonseca, Fernando Rodrı́guez de

doi:10.1016/j.prdoa.2022.100163

Cited by 2 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among detectable samples, PD patients had significantly elevated levels of salivary ATP13A2 compared to controls. Furthermore, significant correlations between ATP13A2 and total UPDRS, UPDRS III, IV, H&Y scale, and disease duration were noticed [54].…”

Section: Other Enzymesmentioning

confidence: 89%

Salivary Biomarkers for Parkinson’s Disease: A Systematic Review with Meta-Analysis

Nijakowski,

Owecki,

Jankowski

et al. 2024

Cells

View full text Add to dashboard Cite

Parkinson’s Disease (PD) is a common neurodegenerative disease which manifests with motor features, such as bradykinesia, resting tremor, rigidity, and postural instability. Using the non-invasive technique of saliva collection, we designed a systematic review to answer the question “Are salivary biomarkers reliable for the diagnosis of Parkinson’s Disease?”. Following inclusion and exclusion criteria, 30 studies were included in this systematic review (according to the PRISMA statement guidelines). Mostly proteins were reported as potential biomarkers in saliva. Based on meta-analysis, in PD patients, salivary levels of total alpha-synuclein were significantly decreased, and those of oligomeric alpha-synuclein were significantly increased. Also, according to pooled AUC, heme oxygenase-1 demonstrated significant predictive value for saliva-based PD diagnosis. In conclusion, some potential biomarkers, especially alpha-synuclein, can be altered in the saliva of PD patients, which could be reliably useful for early diagnosis of this neurodegenerative disease differentiating other synucleopathies.

show abstract

Section: Other Enzymesmentioning

confidence: 89%

Salivary Biomarkers for Parkinson’s Disease: A Systematic Review with Meta-Analysis

Nijakowski,

Owecki,

Jankowski

et al. 2024

Cells

View full text Add to dashboard Cite

show abstract

“…The loss of ATP13A2 has been reported in an atypical form of PD, which was determined to cause dysfunction in lysosomal membrane integrity, as it alters the dysfunction of spermidine/spermine exports and consequently promotes the accumulation of α-synuclein [76,77]. Nowadays, efforts to measure the ATP13A2 levels in serum or saliva raise the possibility of it functioning as a potential marker of PD development and complications [78,79]. In general, these findings highlight the importance of studying PA export dysfunction related to ATP13A2 loss in neurodegeneration and through autophagy regulation, which may represent a therapeutic target for delaying these neurodegenerative conditions.…”

Section: The Role Of Pas In Parkinson's Diseasementioning

confidence: 99%

The Molecular Role of Polyamines in Age-Related Diseases: An Update

Jimenez Gutierrez,

Borbolla Jiménez,

Muñoz

et al. 2023

IJMS

View full text Add to dashboard Cite

Polyamines (Pas) are short molecules that exhibit two or three amine groups that are positively charged at a physiological pH. These small molecules are present in high concentrations in a wide variety of organisms and tissues, suggesting that they play an important role in cellular physiology. Polyamines include spermine, spermidine, and putrescine, which play important roles in age-related diseases that have not been completely elucidated. Aging is a natural process, defined as the time-related deterioration of the physiological functions; it is considered a risk factor for degenerative diseases such as cardiovascular, neurodegenerative, and musculoskeletal diseases; arthritis; and even cancer. In this review, we provide a new perspective on the participation of Pas in the cellular and molecular processes related to age-related diseases, focusing our attention on important degenerative diseases such as Alzheimerߣs disease, Parkinsonߣs disease, osteoarthritis, sarcopenia, and osteoporosis. This new perspective leads us to propose that Pas function as novel biomarkers for age-related diseases, with the main purpose of achieving new molecular alternatives for healthier aging.

show abstract

Salivary ATP13A2 is a potential marker of therapy-induced motor complications and is expressed by inclusions in submandibulary glands in Parkinson ́s disease

Cited by 2 publications

References 29 publications

Salivary Biomarkers for Parkinson’s Disease: A Systematic Review with Meta-Analysis

Salivary Biomarkers for Parkinson’s Disease: A Systematic Review with Meta-Analysis

The Molecular Role of Polyamines in Age-Related Diseases: An Update

Contact Info

Product

Resources

About