Salivary Androgens in Hirsutism: Are They of Use in Routine Evaluation?

Wang, C; Wakelin, Kate; White, Jessica D.; Wood, Peter

doi:10.1177/000456328602300517

Cited by 11 publications

(6 citation statements)

References 21 publications

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“…This would mean that the correlation between the ratio T,,,/ T,,, and the terminal hair reflects a metabolic effect as in the case of DHT ratio. Similarly, in women with hirsutism, T,,, is elevated in only maximally 50% of the cases and the best indicator is the free testosterone index (Wang et al, 1986).…”

Section: Trunk and Limb Hairmentioning

confidence: 95%

“…Uno, 1986). Most studies refer to female hirsutism (Rosenfield, 1971;Maroulis, 1981;Moll e t al., 1981;Baxendale et al, 1982;Cunningham et al, 1983;Lundberg et al, 1983;Mowszowicz et al, 1983;Holdaway et al, 1984;Cumming and Wall, 1985;Andreyko et al, 1986;Schmidt et al, 1986;Wang et al, 1986;Ruutiainen et al, 1987;Vexiau et al, 1990); many also refer to male and/or female baldness (alopecia) (Hamilton, 1942;Muller, 1974;Schweikert and Wilson, 1974;Norwood, 1975;Hodgins and Hay, 1976;Burton et al, 1979;Cipriani et al, 1983;Mortimer et al, 1984;van der Willigen et al, 1987; see also Price, 1988). In contrast, one seldom finds empirical studies in which the variability of terminal hair growth, i.e., of the hair appearing at puberty, is compared with the variability of androgen levels in healthy men.…”

mentioning

confidence: 99%

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Relations between sex hormone level and characters of hair and skin in healthy young men

Knussmann¹,

Christiansen

Kannmacher

1992

American J Phys Anthropol

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Total testosterone and dihydrotestosterone in blood serum as well as free testosterone in saliva were determined by radioimmunoassay in 110 healthy young men. The results were compared with the development of terminal hair on the trunk and limbs, with the disposition to balding and with the disposition to acne. No significant correlations were found between terminal hair development and absolute androgen levels; however, some significant values were observed in the case of the metabolic rate of dihydrotestosterone/testosterone and the proportion of free to total testosterone. The disposition to balding also correlates positively with the latter ratio. Yet the absolute serum androgen concentrations in men with a disposition to balding is lower than in men with no reduction of scalp hair. The widespread assumption that androgen levels are in general elevated in bald-trait men must therefore be rejected. In accordance with this finding, men with a disposition to balding are morphologically (with regard to anthropometric measures) no more masculine than those with good scalp hair growth. When body build and age are taken into consideration, the relations between terminal hair and androgen ratio are also problematical. No relationship could be found between acne and androgens.

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Section: Trunk and Limb Hairmentioning

confidence: 95%

mentioning

confidence: 99%

Relations between sex hormone level and characters of hair and skin in healthy young men

Knussmann¹,

Christiansen

Kannmacher

1992

American J Phys Anthropol

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“… 66 Conversely, when quantifying its distal metabolite, 3α, 17β-androstanediol glucuronide (3α-diol), a better correlation is attained with the androgens’ peripheral activity, mainly when related to the idiopathic cases of hirsutism. 67 Cappel et al analyzing the dosage of hormones related to the severity of acne verified an increase in the amount of DHT in women with persistent acne and a higher number of lesions. 50 …”

Section: Hormones and Peripheral Metabolismmentioning

confidence: 98%

Adult-onset acne: prevalence, impact, and management challenges

Rocha¹,

Bagatin²

2018

CCID

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Acne is a multifactorial and inflammatory disease of pilosebaceous follicles, which affects most adolescents. Recent epidemiological data revealed a difference in adults affected by this disease. Women have a high prevalence and incidence when compared with men, especially after 25 years of age. In contrast to what was initially thought, most of these patients do not present endocrinopathy capable of leading to the development of the lesions. When present, polycystic ovarian syndrome is the main cause. However, in these cases, acne is rarely the only dermatological manifestation; hirsutism and acanthosis nigricans are often present. The majority of the normoandrogenic acne patients present a history since adolescence, but in many cases the lesion distribution and intensity change with time. There is often a typical localization of the lesions in the lower third of the face and lateral region of the neck. Another interesting feature is related to the impact on quality of life (QoL), which is always intense. Often there are signs of depression, even when the lesions are mild. As most adult patients are women, in addition to the conventional options, there is also hormone treatment. Combined oral contraceptives and spironolactone are good options. Knowing more about the particularities in etiopathogenesis, impact on QoL, and specific treatment options is important to all dermatologists who face the challenge of treating acne in adults.

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“…10,11 The use of salivary testosterone to assess hyperandrogenism in hirsute women is limited by a wide overlap between male and female reference ranges (Drs Teoh and Wallace, Glasgow Royal Infirmary, personal communication), and a single salivary testosterone result has been reported to give poorer discrimination than the conventional serum free androgen index. 96 Salivary testosterone measurements may have some useful applications however.…”

Section: Salivary Testosteronementioning

confidence: 99%

Salivary steroid assays – research or routine?

2009

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Salivary concentrations of unconjugated steroids reflect those for free steroids in serum although concentrations may differ because of salivary gland metabolism. Samples for salivary steroid analysis are stable for up to 7 days at room temperature, one month or more at 48C and three months or more at 2208C. When assessed against strict criteria, the evidence shows that salivary cortisol in evening samples or following dexamethasone suppression provides a reliable and effective screen for Cushing's syndrome. Sequential salivary cortisol measurements are also extremely helpful for the investigation of suspected cyclical Cushing's syndrome. There is potential for the identification of adrenal insufficiency when used with Synacthen stimulation. Salivary 17-hydroxyprogesterone and androstenedione assays are valued as non-invasive tests for the homemonitoring of hydrocortisone replacement therapy in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. The diagnostic value of salivary oestradiol, progesterone, testosterone, dehydroepiandrosterone and aldosterone testing is compromised by rapid fluctuations in salivary concentrations of these steroids. Multiple samples are required to obtain reliable information, and at present the introduction of these assays into routine laboratory testing is not justified.

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Salivary Androgens in Hirsutism: Are They of Use in Routine Evaluation?

Cited by 11 publications

References 21 publications

Relations between sex hormone level and characters of hair and skin in healthy young men

Relations between sex hormone level and characters of hair and skin in healthy young men

Adult-onset acne: prevalence, impact, and management challenges

Salivary steroid assays – research or routine?

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