Salivary and Lacrimal Glands

Gnepp, Douglas R.; Henley, John; Simpson, Roderick H.W.; Eveson, J.W.

doi:10.1016/b978-1-4160-2589-4.00006-1

Cited by 75 publications

(88 citation statements)

References 1,064 publications

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“…Salivary glands may give rise to a wide spectrum of different tumors [1,2]. They are often diagnostically challenging with interesting and controversial morphological features often overlapping between different entities.…”

Section: Introductionmentioning

confidence: 99%

Mammary Analogue Secretory Carcinoma of Salivary Gland Origin: An Update and Expanded Morphologic and Immunohistochemical Spectrum of Recently Described Entity

Skálová

2013

Head and Neck Pathol

130

125

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Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor with ETV6 translocation. Akin to secretory breast cancer, MASC expresses S-100 protein, mammaglobin, vimentin, and harbors a t(12;15) (p13;q25) translocation which leads to ETV6-NTRK3 fusion product. Histologically, MASC displays a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogeneous or bubbly secretions. Colloidlike secretory material stains positive for periodic acidSchiff (PAS) with and without diastase and for Alcian blue. The cells of MASC are devoid of PAS-positive secretory zymogen granules. These features help to exclude the most important differential diagnostic considerations, namely acinic cell carcinoma, low-grade cribriform cystadenocarcinoma, cystadenocarcinoma (not otherwise specified), and low-grade mucoepidermoid carcinoma. To date the presence of the ETV6-NTRK3 fusion gene has not been demonstrated in any other salivary gland tumor than MASC. It is likely that MASC is more common than currently recognized and with further studies, the clinical need for molecular studies of the ETV6-NTRK3 fusion may diminish. However, molecular testing is recommended at this time to arrive at the diagnosis of MASC.

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Section: Introductionmentioning

confidence: 99%

Mammary Analogue Secretory Carcinoma of Salivary Gland Origin: An Update and Expanded Morphologic and Immunohistochemical Spectrum of Recently Described Entity

Skálová

2013

Head and Neck Pathol

130

125

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“…Basal cell adenoma is a rare histological type of parotid gland tumor with a reported incidence of 1-3% of all primary salivary gland tumors worldwide (2,12). More than 80% of basal cell adenomas arise in the major salivary glands, mostly in the parotid glands (13).…”

Section: Discussionmentioning

confidence: 99%

Synchronous double basal cell adenoma of the parotid gland: Report of a case

et al. 2008

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Salivary gland tumors commonly occur as a single focus in one salivary gland.Warthin tumor often arises in bilateral parotid glands, and the membranous type of basal cell adenoma frequently occurs in unilateral parotid glands. We describe herein a case of extremely rare synchronous double solid type basal cell adenoma arising in the left parotid glands in a 49-year-old woman. This case was treated with surgical enucleation, and no signs of recurrence have been seen as of 4 years 3 months after surgery.

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“…Acinic cell carcinoma occurs in the parotid gland more often than primary planoepithelial carcinoma. Besides the parotid gland the tumour can be seen in the submandibular gland, lacrimal glands and minor salivary glands of the oral cavity, throat and larynx [3]. In comparison to other salivary gland malignancies (adenoid cystic carcinoma or salivary duct carcinoma) ACC malignancy is quite low.…”

Section: Introductionmentioning

confidence: 98%

“…Evidence of facial nerve involvement with paresis or paralysis (present in 3-7.5% of cases) seems to be an ominous sign. Tumour diameter greater than 3 cm and adjacent tissue invasion are found to be other unfavourable prognostic factors [3,5]. Sometimes ACC coexists with pituitary adenoma or releases ACTH, leading to Cushing syndrome [6,7].…”

Section: Introductionmentioning

confidence: 99%