Salivary analysis: An emerging paradigm for non‐invasive healthcare diagnosis and monitoring

Abstract

As an emerging non-invasive and easy-to-use toolkit, salivary analysis has garnered significant attention recently. By leveraging the latest discoveries in salivary biomarkers, salivary analysis has the potential to revolutionize the field of healthcare by providing valuable information for monitoring an individual's health status, diagnosing disease progression, and enabling personalized treatment. However, the transitional development of breakthrough salivary analysis remains an intriguing challenge. Only a few innovations have progressed to new transformative healthcare diagnosis and monitoring tools. In this review, we attempt to illustrate a bird's eye view of the emerging field of salivary analysis by exploring an assorted selection of seminar progress that can potentially shape the developing trajectory of the field of salivary analysis. The fundamental nature of saliva and the versatile robust uses of salivary analysis as a novel non-invasive method in various healthcare diagnostic and monitoring fields will be thoroughly discussed. To inspire next-stage development in this thriving and fruitful field, we also crystalize key findings, pinpoint challenges that remain to be addressed and present an outlook on the future transitional development of salivary analysis, invigorating future research of groundbreaking non-invasive healthcare diagnosis and monitoring strategies, and beyond.

Colorimetric sweat analysis using wearable hydrogel patch sensors for detection of chloride and glucose

“…Storage stability refers to the ability of the sensor to retain its performance and functionality over time when stored under specific conditions. 51,52 In our case, certain sensor materials may exhibit degradation or chemical reactions that can lead to changes in their sensing performance, resulting in unreliable or inaccurate measurements. Our results showed that the prepared colorimetric sensors, including the chlorine sensor and glucose sensor, could only sustain 1 day when kept in the lab environment (∼25 °C, humidity level: ∼50%) and maintained sufficient sensing capability for 3 days when stored in a refrigerator (∼4–8 °C, humidity level: ∼40–50%).…”

Expression of Salivary HIF-1α Levels Among the Clinical Stages of Oral Submucous Fibrosis

“…Early detection of disease is key to decreasing morbidity, and mortality and preventing the complications of disease 21,22 . The role of saliva has been extensively reported not only because of its ease of availability and non-invasive nature of procedure but also due to the abundance of *p-value < 0.05 is considered significant, the Kruskal Wallis, Kendall Tau's Correlation test and, Binary logistic regression were applied genetic material and proteins in saliva samples 23,24 .…”

Oral and gut microbial profiling in periodontitis and Parkinson’s disease

“…We worked with saliva samples to provide microbial information about the oral cavity. The analysis of the salivary microbiome has gained attention as a non-invasive method for assessing oral and systemic health [ 27 ]. Changes in the salivary microbiome have been linked to periodontal disease, dental caries, and systemic diseases like diabetes and cardiovascular disease [ 28 ].…”